Results 51 to 60 of about 151,971 (294)

Plugging the Attention Deficit: Perceptual Load Counters Increased Distraction in ADHD. [PDF]

, 2013
Objective: Increased vulnerability to extraneous distraction is a key symptom of Attention-Deficit Hyperactivity Disorder (ADHD), which may have particularly disruptive consequences.
Forster, S, Robertson, David J, Jennings, A, Asherson, P, Forster, Sophie, Sophie Forster (4464244), Nilli Lavie (3323976), Lavie, Nilli, Alistair Jennings (345468), David J Robertson (16176932), Robertson, DJ, Philip Asherson (524714), Lavie, N, Jennings, Alistair, Asherson, Philip; id_orcid   +14 more
core   +1 more source

Nigra‐Subthalamic Dopaminergic Circuitry Modulates and Represents Distinct Pain Modality in Physiological and Pain States in Mice

Advanced Science, EarlyView.
Nigral dopaminergic (DA) neurons modulate and represent pain with a preference to a particular modality (mechanical) and laterality (contralateral), which are controlled by nigral GABAergic neurons. The pain modulation is mimicked by the nigro‐subthalamic projection and its downstream neurons, involving D2‐like receptors.
Ying Ji, Shuyi Li, Jiaqi Zhang, Xiang‐Ying Xu, Cui Yin, Mu Niu, Danyang Liu, Yanyu Jiang, Yong Niu, Su Liu, Bin Zhang, Guiyun Cui, Chunyi Zhou, Cheng Xiao   +13 more
wiley   +1 more source

An Activity‐Dependent NEPAS–PTX3 Axis Links Neurovascular and Myelin Deficits to Cognitive Impairment

Advanced Science, EarlyView.
An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu, Zifei Chen, Bingmei Sun, Jiale Gao, Jiale Xu, Xiaochun Guo, Fenfei Gao, Zhongsi Wang, Jie Wu, Xiaoyu Ji, Peipei Liu, Bing Huang   +11 more
wiley   +1 more source

Efficacy of lisdexamfetamine dimesylate throughout the day in children and adolescents with attention-deficit/hyperactivity disorder:results from a randomized, controlled trial [PDF]

, 2013
Lisdexamfetamine dimesylate (LDX) is a long-acting, prodrug stimulant therapy for patients with attention-deficit/hyperactivity disorder (ADHD). This randomized placebo-controlled trial of an optimized daily dose of LDX (30, 50 or 70 mg) was conducted in
Squires, Liza A., Bloomfield, Ralph, Dittmann R. W, Dittmann, RW, Coghill D. R, Squires, LA, Banaschewski, Tobias, Zuddas, Alessandro, Ralph Bloomfield, Coghill, David R, Lecendreux, Michel, Civil, R, Civil R, Civil, Richard, Squires L. A., Banaschewski T, Isabel Hernández Otero, Dittmann, Ralf W, Michel Lecendreux, Hernández Otero, Isabel, Squires, Liza A, Otero, IH, Alessandro Zuddas, Otero I. H, Lecendreux M, Coghill, DR, Tobias Banaschewski, David R. Coghill, Richard Civil, Banaschewski, T, Coghill, David R., Liza A. Squires, Otero, Isabel Hernández, Dittmann, Ralf W., Zuddas, A, Lecendreux, M, Bloomfield, R, Ralf W. Dittmann, Bloomfield R   +38 more
core   +1 more source

mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling

Advanced Science, EarlyView.
Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim, Huajie Wang, Gao Qianqian, Abdul Waris, Jufang He   +4 more
wiley   +1 more source

How teachers′ knowledge of attention deficit hyperactivity disorder makes difference in doctors′ diagnostic decisions and management?

Saudi Journal of Medicine and Medical Sciences, 2015
Objective: The teacher′s knowledge plays a key role in the process of assessing, screening, and diagnosing attention deficit hyperactivity disorder.
Mohamed S Khalil, Elham Jenahi
doaj   +1 more source

Palatable‐Food–Driven Top‐Down Circuit Inhibits PVNCRF Activity to Mitigate Stress Via Peri‐PVNCRFR1 Neurons

Advanced Science, EarlyView.
Palatable food alleviates stress and prevents anxiety. This study uncovers a dedicated neural pathway: dopamine release in the PFC activates D1R neurons, whose projections to the peri‐PVN engage a population of anxiolytic CRFR1 neurons. These neurons then inhibit stress‐induced hyperactivity of PVNCRF neurons, providing a circuit‐level explanation for ...
Yuchuan Hong, Shirui Jun, Tianjiao Deng, Gaojie Shao, Dan Liu, Yi Sun, Yan Chen, Qian Xiao, Jie Shao, Sheng Wang, Tianwen Huang, Fan Yang, Jie Tu   +12 more
wiley   +1 more source

Household task participation of children and adolescentes with ADHD: a systematic review

Cadernos Brasileiros de Terapia Ocupacional, 2018
Introduction: In the Attention-Deficit/Hyperactivity Disorder (ADHD), the identification of functional impairments in home context is an important feature for the diagnosis.
Camila Guimarães Mendes, Marisa Cotta Mancini, Débora Marques Miranda   +2 more
doaj   +1 more source

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

Treatment of attention deficit hyperactivity disorder with monoamine amino acid precursors and organic cation transporter assay interpretation

Neuropsychiatric Disease and Treatment, 2011
Marty Hinz1, Alvin Stein2, Robert Neff3, Robert Weinberg4, Thomas Uncini51NeuroResearch Clinics Inc, Cape Coral, FL; 2Stein Orthopedic Associates, Plantation, FL; 3Mental Training Inc, Dallas, TX; 4Department of Kinesiology and Health, Miami University ...
Marty Hinz, Alvin Stein, Robert Neff, et al   +3 more
doaj