Results 31 to 40 of about 446,134 (267)

On Hierarchical Composite Endpoints in Pediatric Cancer Supportive Care: Illustrative Examples From Two Multi‐Center Phase‐III Randomized Clinical Trials

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric supportive care clinical trials often involve multiple clinically important outcomes, complicating trial interpretation. Hierarchical composite endpoints (HCEs) provide a framework to integrate key outcomes according to clinical importance.
Willem H. Collier, Mark Zobeck, Adam J. Esbenshade, Christopher C. Dvorak, Lillian Sung, David Freyer, Sarah Alexander, Etan Orgel, Nicole J. Ullrich, Zach Prudowsky, Brian Fisher, Caitlin W. Elgarten   +11 more
wiley   +1 more source

Screening of Mycobacterium avium subsp. paratuberculosis Mutants for Attenuation in a Bovine Monocyte-Derived Macrophage Model

Frontiers in Cellular and Infection Microbiology, 2014
Vaccination remains a major tool for prevention and progression of Johne’s disease, a chronic enteritis of ruminants worldwide. Currently there is only one licensed vaccine within the United States and two vaccines licensed internationally against Johne’
Elise A Lamont, Adel M Talaat, Paul M Coussens, John eBannantine, Yrjo Tapio Grohn, Robab eKatani, Lingling eLi, Vivek eKapur, Srinand eSreevastan   +8 more
doaj   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Anaerobic Bioremediation of Groundwater Containing High Concentrations of cis-1,2-Dichloroethene Using Solid Amendments

Revista Águas Subterrâneas, 2013
A ruptured degreaser introduced trichloroethylene (TCE) into groundwater at an industrial facility in Stephenville, TX. Groundwater near the source zone (30m by 15m) had TCE concentrations near 500 mg/L, suggesting that un-dissolved contaminant was ...
John Freim, Clint Bickmore, Richard Varnell, Sam Fogel, William Newman   +4 more
doaj  

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Recombinant Live-Attenuated Salmonella Vaccine for Veterinary Use

Vaccines
Vaccination is essential for maintaining animal health, with priority placed on safety and cost effectiveness in veterinary use. The development of recombinant live-attenuated Salmonella vaccines (RASVs) has enabled the construction of balanced lethal ...
Domitila Brzoskowski Chagas, Francisco Denis Souza Santos, Natasha Rodrigues de Oliveira, Thaís Larré Oliveira Bohn, Odir Antônio Dellagostin   +4 more
doaj   +1 more source

Attenuation From Shoes and Pads in Equine Nuclear Scintigraphy, With Relevance to Solar Views

Frontiers in Veterinary Science, 2020
Nuclear scintigraphy can be beneficial in the investigation of equine lameness and poor performance. Images obtained through the sole allow for better identification of a region of increased radionuclide uptake in the foot.
Lea Walker, Mark J. Martinelli, Norman Rantanen, Bianca Drumond, Steven Trostle   +4 more
doaj   +1 more source

Attenuation correction in SPECT without attenuation map [PDF]

2011 IEEE Nuclear Science Symposium Conference Record, 2011
A method of attenuation correction in Single Photon Emission Computed Tomography (SPECT), based on emission data only is presented. The algorithm uses the well known Helgason-Ludwig consistency conditions. However, it does not attempt to find the attenuation map, but rather the correction factors for the projection data, which makes the problem simpler
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source