Results 61 to 70 of about 49,586 (211)

Solving Parity Games in Scala [PDF]

, 2015
Parity games are two-player games, played on directed graphs, whose nodes are labeled with priorities. Along a play, the maximal priority occurring infinitely often determines the winner.
Aniello, Murano, DI STASIO, ANTONIO, Loredana, Sorrentino, Vincenzo, Prignano   +3 more
core   +1 more source

Plasmin activity promotes amyloid deposition in a transgenic model of human transthyretin amyloidosis

Nature Communications, 2021
ATTR amyloidosis causes heart failure through the accumulation of misfolded transthyretin in cardiac muscle. Here the authors report a mouse model of ATTR amyloidosis and demonstrate the involvement of protease activity in ATTR amyloid deposition.
Ivana Slamova, Rozita Adib, Stephan Ellmerich, Michal R. Golos, Janet A. Gilbertson, Nicola Botcher, Diana Canetti, Graham W. Taylor, Nigel Rendell, Glenys A. Tennent, Guglielmo Verona, Riccardo Porcari, P. Patrizia Mangione, Julian D. Gillmore, Mark B. Pepys, Vittorio Bellotti, Philip N. Hawkins, Raya Al-Shawi, J. Paul Simons   +18 more
doaj   +1 more source

Transthyretin amyloid cardiomyopathy in aortic stenosis patients scheduled for transcatheter aortic valve implantation

ESC Heart Failure
Aims The prevalences of aortic stenosis (AS) and transthyretin amyloid cardiomyopathy (ATTR‐CM) increase with age. Identification of occult ATTR‐CM in patients with AS can help explain out‐of‐proportion myocardial dysfunction, aid in prognostication and ...
Margrethe Flesvig Holt, August Flø, Esra Kaya, Sophie Foss Kløve, Hege Martinsen, Kristine Amlie, Petter Storsten, Thomas Misje Mathiisen, Kristoffer Russell, Christian Hesbø Eek, Helge Skulstad, Melinda Raki, Lars Gullestad, Anders Hodt, Einar Gude, Kaspar Broch   +15 more
doaj   +1 more source

Tafamidis decreased cardiac amyloidosis deposition in patients with Ala97Ser hereditary transthyretin cardiomyopathy: a 12-month follow-up cohort study

Orphanet Journal of Rare Diseases, 2023
Background Transthyretin cardiac cardiomyopathy (ATTR-CM) is a rare but life-threatening disease. Tafamidis is an effective treatment for patients with ATTR-CM, however its long-term effects on cardiac remodeling and cardiac amyloid deposition are ...
Cheng-Hsuan Tsai, Chi-Chao Chao, Sung-Tsang Hsieh, An-Li Yu, Yuan-Kun (Aden) Wu, Mei-Fang Cheng, Ming-Jen Lee, Chia-Hung Chou, Chia-Tung Shun, Hsueh-Wen Hsueh, Jimmy Jyh-Ming Juang, Ping-Huei Tseng, Mao-Yuan Su, Yen-Hung Lin   +13 more
doaj   +1 more source

Ultra High‐Resolution Ultrasound Features of Carpal Tunnel Syndrome in Transthyretin Amyloidosis: A Cross‐Sectional Study

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims Transthyretin amyloidosis (ATTR), including hereditary (hATTR) and wild‐type (wtATTR), often presents initially as carpal tunnel syndrome (CTS), often preceding systemic symptoms by several years. Ultra high‐resolution ultrasound (UHRUS) offers detailed visualization of peripheral nerve morphology, but its application in ATTR‐
Rachana K. Gandhi Mehta, Nicholas Miller, Michael S. Cartwright, Rebecca Traub, Joni Evans   +4 more
wiley   +1 more source

Epidemiology of transthyretin (ATTR) amyloidosis: a systematic literature review

Orphanet Journal of Rare Diseases
Introduction Significant advances in the treatment of transthyretin (ATTR) amyloidosis has led to an evolving understanding of the epidemiology of this condition. This systematic literature review (SLR) aims to synthesize current evidence on epidemiology
Diego Delgado, Firas Dabbous, Nitin Shivappa, Faizan Mazhar, Eric Wittbrodt, Divya Shridharmurthy, Krister Järbrink   +6 more
doaj   +1 more source

Diagnosis of Amyloidosis: A Survey of Current Awareness and Clinical Challenges Among Cardiologists in Switzerland

Cardiology and Therapy, 2020
Introduction Transthyretin amyloidosis (ATTR) is a progressive disease in which amyloid fibril deposition disrupts tissue structure and organ function. Many patients with ATTR present with cardiac involvement; recent studies indicate that ATTR prevalence
Dennis Mircsof
doaj   +1 more source

Evolving trends in epidemiology and natural history of cardiac amyloidosis: 30-year experience from a tertiary referral center for cardiomyopathies

Frontiers in Cardiovascular Medicine, 2022
ObjectiveNatural history of cardiac amyloidosis (CA) is poorly understood. We aimed to examine the changing mortality of different types of CA over a 30-year period.Patients and methodsConsecutive patients included in the “Trieste CA Registry” from ...
Aldostefano Porcari, Valentina Allegro, Riccardo Saro, Guerino Giuseppe Varrà, Linda Pagura, Maddalena Rossi, Andrea Lalario, Francesca Longo, Renata Korcova, Matteo Dal Ferro, Andrea Perkan, Franca Dore, Rossana Bussani, Giovanni Maria De Sabbata, Francesco Zaja, Francesco Zaja, Marco Merlo, Gianfranco Sinagra   +17 more
doaj   +1 more source

Generating Compressed Counterfactual Hard Negative Samples for Graph Contrastive Learning

CAAI Transactions on Intelligence Technology, EarlyView.
ABSTRACT Graph contrastive learning (GCL) relies on acquiring high‐quality positive and negative samples to learn the structural semantics of the input graph. Previous approaches typically sampled negative samples from the same training batch or an irrelevant external graph.
Haoran Yang, Hongxu Chen, Xiangyu Zhao, Sixiao Zhang, Xiangguo Sun, Qian Li, Hongzhi Yin, Guandong Xu   +7 more
wiley   +1 more source

Natural history and progression of transthyretin amyloid cardiomyopathy: insights from ATTR‐ACT

ESC Heart Failure, 2021
Aims Transthyretin amyloid cardiomyopathy (ATTR‐CM) is a progressive, fatal disorder that remains underdiagnosed. The Tafamidis in Transthyretin Cardiomyopathy Clinical Trial (ATTR‐ACT) was the first large clinical trial to include both wild‐type (ATTRwt)
Jose Nativi‐Nicolau, Daniel P. Judge, James E. Hoffman, Balarama Gundapaneni, Denis Keohane, Marla B. Sultan, Martha Grogan   +6 more
doaj   +1 more source