Results 71 to 80 of about 669,840 (357)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Global Existence and Stability for Neutral Functional Evolution Equations with State-Dependent Delay
Nonautonomous Dynamical Systems, 2014 In this paper we prove the global existence and attractivity of mild solutions for neutral semilinear evolution equations with state-dependent delay in a Banach space.
Baliki Abdessalam, Benchohra Mouffak
doaj +1 more source
Qualitative analysis for two fractional difference equations
Nonlinear Engineering, 2020 Some difference equations are generally studied by investigating their long behaviours rather than their exact solutions. The proposed equations cannot be solved analytically.
Almatrafi Mohammed B. +1 more
doaj +1 more source
Global stability of an SIS epidemic model with a finite infectious period [PDF]
, 2017 Assuming a general distribution for the sojourn time in the in- fectious class, we consider an SIS type epidemic model formulated as a scalar integral equation. We prove that the endemic equilibrium of the model is globally asymptotically stable whenever
Nakata, Yukihiko, Rost, Gergely
core +1 more source
, 2015 In this paper, we consider the almost periodic dynamics of a multispecies Lotka-Volterra mutualism system with time varying delays on time scales. By establishing some dynamic inequalities on time scales, a permanence result for the model is obtained ...
Li, Yongkun, Wang, Pan
core +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Investment Attractiveness of Regions: Classification Analysis for the Volga Federal District [PDF]
, 2021 Евгений Петрович Митрофанов +1 more
openalex +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
InfrastructuresAccessibility and the so-called ‘15 min city’ paradigm are critical dimensions in agendas involving urban policies. However, when interested in accounting for accessibility from a formal perspective, researchers and practitioners should use pertinent ...
Fabrizio Boninsegna +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source