Results 101 to 110 of about 144,099 (322)
Molecular Oncology, EarlyView.Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser +14 more
wiley +1 more source
, 2011 A simple threshold model of neuron firing (with the neuron membrane electrochemical potential governed by the chaotic Rossler attractor) has been analyzed by mapping the generated irregular spiking time-series into telegraph signals.
Bershadskii, A., Ikegaya, Y.
core +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Attractor behaviour in ELKO cosmology
, 2012 We study the dynamics of ELKO in the context of accelerated phase of our universe. To avoid the fine tuning problem associated with the initial conditions, it is required that the dynamical equations lead to an early-time attractor. In the earlier works,
Basak, Abhishek +3 more
core +1 more source
PLoS ONE, 2013 The experimental observations and numerical studies with dissipative metabolic networks have shown that cellular enzymatic activity self-organizes spontaneously leading to the emergence of a Systemic Metabolic Structure in the cell, characterized by a set of different enzymatic reactions always locked into active states (metabolic core) while the rest ...
Fuente, Ildefonso M. de la +3 more
openaire +6 more sources
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
MathematicsIn this paper, we examine a sequence of uncountable iterated function systems (U.I.F.S.), where each term in the sequence is constructed from an uncountable collection of contraction mappings along with a linear and continuous operator.
Ion Mierluș–Mazilu, Lucian Niță
doaj +1 more source
Frontiers in Genetics, 2013 Boolean networks (BoN) are relatively simple and interpretable models of gene regulatorynetworks. Specifying these models with fewer parameters while retaining their ability to describe complex regulatory relationships is an ongoing methodological ...
Van eTran +3 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source