Results 51 to 60 of about 29,134 (219)

Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials

British Journal of Pharmacology, EarlyView.
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen, Declan P. McKernan, John P. Kelly   +2 more
wiley   +1 more source

Preliminary study on cardiovascular and biochemical responses to atypical and typical antipsychotic medication in schizophrenic patients

Brain Disorders
Antipsychotic medications are essential for managing schizophrenia but are associated with metabolic side effects. This study aims to compare the cardiovascular effects of typical and atypical antipsychotic drugs in schizophrenic patients. A total of 200
Olayemi F. Fagbomedo, Jamiyu A. Saliu, Damilola A. Omoboyowa, Anthony M. Agesin   +3 more
doaj   +1 more source

Novel Histopathologic Features of Diffuse Blue‐Gray Hyperpigmentation Associated With Kratom Use: A Case Report and Literature Review

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Background Drug‐induced hyperpigmentation accounts for 10%–20% of acquired pigmentary disorders and can be misdiagnosed for other causes such as melasma, post inflammatory changes, or heavy metal deposition. Kratom (Mitragyna speciosa), a Southeast Asian plant with an opioid‐like profile, has been increasingly used in the United States for ...
Rita Kamoua, Kristen Paradine, Craig A. Rohan, Mary McDaniel, Diane Perkins   +4 more
wiley   +1 more source

Effective Treatment With Olanzapine for Burning Mouth Syndrome With Denture Intolerance in an Older Patient: A Case Report

Gerodontology, EarlyView.
ABSTRACT Introduction Burning mouth syndrome (BMS) is occasionally accompanied by denture intolerance. Case Presentation An 80‐year‐old woman with complaints of residual and relapsed intraoral pain and denture intolerance due to BMS was improved by olanzapine without severe adverse events, and her eating ability was successfully restored.
Motoko Watanabe, Masanao Inokoshi, Chizuko Maeda, Chihiro Takao, Risa Tominaga, Yasuyuki Kimura, Takahiko Nagamine, Akira Toyofuku   +7 more
wiley   +1 more source

Impact of modafinil add-on with atypical anti-psychotics on excessive daytime drowsiness

Indian Journal of Psychological Medicine, 2015
Background: Atypical antipsychotic drugs are known to cause many side effects which include daytime drowsiness. So many add on drugs are tried to reduce the same.
P Lakshmi Prasuna, T P Sudhakar
doaj   +1 more source

When Delirium Unmasks a Silent Myocardial Infarction

Journal of the American Geriatrics Society, EarlyView.
Abbreviations: hs‐TnT: high sensitivity Troponin T; STEMI: ST‐elevation myocardial infarction.
Eugenia Casali, Wenxiang Guo, Eleonora Cucini, Francesca Pisani, Alberto Finazzi, Maria Cristina Ferrara, Maurizio Corsi, Elena Pinardi, Chukwuma Okoye, Paolo Mazzola, Giuseppe Bellelli   +10 more
wiley   +1 more source

Antipsychotic Use Among Intellectually Disabled Individuals With Rare Genetic Variants That Confer Risk for Schizophrenia

Journal of Intellectual Disability Research, EarlyView.
ABSTRACT Background Rare genetic variation can predispose individuals to the development of schizophrenia, with certain genes and copy number variants (CNVs) conferring risk at the exome/genome‐wide level. Despite this strong association, little is known about antipsychotic effectiveness and tolerability among individuals with most of these disorders ...
Mark Ainsley Colijn
wiley   +1 more source

Metformin for the Prevention of Weight Gain due to Atypical Antipsychotics [PDF]

Psikiyatride Güncel Yaklaşımlar, 2011
Excessive weight gain, hyperglycemia, type 2 diabetes and hyperlipidemia are significant clinical adverse effects that appear as a result of the treatment with second generation atypical antipsychotic drugs.
Nazmiye Kaya, Erdem Onder Sonmez
doaj  

OLANZAPINE : A NEW "ATYPICAL" ANTÎPSYCHOTİC

Psychiatry and Clinical Psychopharmacology, 2021
O lanzapine is a new "aty p ical" w hose chem ical stru cture is sim ilar to clozapine. O lanzapine, w hich belongs to the thienobenzodiazepine class, has a greater binding affinity for 5-H T 2 com pared to D2 receptors and has a m esolim bic ...
E.Cüneyt Evren
doaj  

Treatment Discontinuation Among Patients with Schizophrenia Treated with Brexpiprazole and Other Oral Atypical Antipsychotics in Japan: A Retrospective Observational Study [PDF]

, 2022
Akitoyo Hishimoto, Norio Yasui‐Furukori, Daisuke Sekine, Miyuki Matsukawa, Sakiko Yamada   +4 more
openalex   +1 more source