Results 1 to 10 of about 4,918 (122)

Possible alignment of the EU BSE surveillance with the new WOAH provisions. [PDF]

EFSA J
The European Commission requested the assessment of the capacity of the surveillance provisions of the World Organization for Animal Health (WOAH) to detect bovine spongiform encephalopathy (BSE) cases (C‐, H‐ and L‐type) in the European Union (EU) and ...
EFSA Panel on Animal Health and Welfare (AHAW), Nielsen SS, Alvarez J, Boklund A, Dippel S, Dórea F, Figuerola J, Herskin MS, Michel V, Miranda Chueca MA, Nannoni E, Riber AB, Stahl K, Stegeman JA, Thulke HH, Tuyttens F, Winckler C, Arnold M, Ducrot C, Griffin J, Ru G, Simmons M, Ashe S, Pelaez AO, Kryemadhi K, Nonno R.   +25 more
europepmc   +3 more sources

Clinical, pathological, and molecular features of classical and L-type atypical-BSE in goats [PDF]

PLoS ONE, 2018
Monitoring of small ruminants for transmissible spongiform encephalopathies (TSEs) has recently become more relevant after two natural scrapie suspected cases of goats were found to be positive for classical BSE (C-BSE). C-BSE probably established itself
Cristina Casalone, Paola Crociara, Elena Vallino Costassa   +2 more
exaly   +4 more sources

Radical Change in Zoonotic Abilities of Atypical BSE Prion Strains as Evidenced by Crossing of Sheep Species Barrier in Transgenic Mice. [PDF]

Emerg Infect Dis, 2020
Classical bovine spongiform encephalopathy (BSE) is the only zoonotic prion disease described to date. Although the zoonotic potential of atypical BSE prions have been partially studied, an extensive analysis is still needed.
Marín-Moreno A, Huor A, Espinosa JC, Douet JY, Aguilar-Calvo P, Aron N, Píquer J, Lugan S, Lorenzo P, Tillier C, Cassard H, Andreoletti O, Torres JM.   +12 more
europepmc   +2 more sources

Discrimination of Classical and Atypical BSE by a Distinct Immunohistochemical PrP^Sc Profile. [PDF]

Pathogens, 2023
Bovine spongiform encephalopathy (BSE) belongs to the group of transmissible spongiform encephalopathies and is associated with the accumulation of a pathological isoform of the host-encoded glycoprotein, designated prion protein (PrPSc).
Fast C, Graham C, Kaatz M, Santiago-Mateo K, Kaatz T, MacPherson K, Balkema-Buschmann A, Ziegler U, Groschup MH, Czub S.   +9 more
europepmc   +2 more sources

Molecular characterisation of atypical BSE prions by mass spectrometry and changes following transmission to sheep and transgenic mouse models. [PDF]

PLoS One, 2018
The prion hypothesis proposes a causal relationship between the misfolded prion protein (PrPSc) molecular entity and the disease transmissible spongiform encephalopathy (TSE). Variations in the conformation of PrPSc are associated with different forms of
Gielbert A, Thorne JK, Plater JM, Thorne L, Griffiths PC, Simmons MM, Cassar CA.   +6 more
europepmc   +2 more sources

Bovine Spongiform Encephalopathy: An Integrated Review of Prion Mechanisms, Neuroanatomy, and Control. [PDF]

Vet Sci
Bovine spongiform encephalopathy (BSE) is a fatal transmissible spongiform encephalopathy caused by the misfolding of the host prion protein (PrP), representing a unique intersection between molecular pathology, neuroanatomy, and public health regulation.
Marzola GP, Abuna RPF, Ribeiro LA, Parra JPRLL, Garcia MHH, Maria Barbalho S, Miglino MA.   +6 more
europepmc   +2 more sources

Deciphering the BSE-type specific cell and tissue tropisms of atypical (H and L) and classical BSE

Prion, 2019
After the discovery of two atypical bovine spongiform encephalopathy (BSE) forms in France and Italy designated H- and L-BSE, the question arose whether these new forms differed from classical BSE (C-BSE) in their pathogenesis.
Anne Balkema-Buschmann, Romano Strobelt, Reiner Ulrich   +2 more
exaly   +3 more sources

Association of a Bovine Prion Gene Haplotype with Atypical BSE [PDF]

PLoS ONE, 2008
BACKGROUND: Atypical bovine spongiform encephalopathies (BSEs) are recently recognized prion diseases of cattle. Atypical BSEs are rare; approximately 30 cases have been identified worldwide. We tested prion gene (PRNP) haplotypes for an association with
Thierry Baron, Michael L. Clawson, William Laegreid   +2 more
exaly   +2 more sources

Protocol for further laboratory investigations into the distribution of infectivity of Atypical BSE [PDF]

EFSA Journal, 2014
Information on the pathogenesis and tissue distribution of Atypical Bovine Spongiform Encephalopathy (BSE) in cattle through the study of field cases and experimental transmission studies is lacking. The latter are limited to transmission of Atypical BSE
European Food Safety Authority
exaly   +2 more sources

Practical Real-Time Quaking-Induced Conversion for Detecting Classical Bovine Spongiform Encephalopathy and Classical and Atypical Scrapie Prions. [PDF]

Pathogens
Real-time quaking-induced conversion (RT-QuIC) is highly sensitive for prion detection; however, inhibitory factors present in tissue homogenates readily interfere with the assay.
Suzuki A, Sawada K, Nakashima T, Sato T, Miyazawa K, Matsuura Y, Ikeda K, Iwamaru Y, Horiuchi M.   +8 more
europepmc   +2 more sources