Results 61 to 70 of about 6,797 (180)

Delayed Diagnosis of Tuberous Sclerosis Complex Presenting as Abnormal Uterine Bleeding: A Case Report and Literature Review

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT Tuberous sclerosis complex (TSC) is a rare multisystem genetic disorder characterized by the development of hamartomatous lesions in multiple organs. Although neurologic and dermatologic manifestations commonly lead to diagnosis during childhood, some patients remain undiagnosed until adulthood because of atypical presentations.
Kidus Tesfaye Bezabih, Hana Sisay Belay, Merid Lemma Kebede, Abebe Ketema Aderu, Mathyas Dessalegn Gebreyes, Kelil Hussein Jibicho, Adugna Assefa Talemahu, Elias Fikre Merid, Kedir Negesso Tukeni   +8 more
wiley   +1 more source

Advances in FGF/FGFR Signaling: Implications for Disease and Therapy

MedComm, Volume 7, Issue 9, September 2026.
The FGF/FGFR signaling is indispensable for the maintenance of physiological homeostasis and governs multiple biological processes, including embryonic development, bone metabolism, angiogenesis, and neurogenesis, whereas aberrant hyperactivation of this pathway drives the progression of malignancies and autoimmune disorders, including inflammatory ...
Miaoyu Song, Xi Liu, Yang Xiao, Yongsheng Li, Huakan Zhao   +4 more
wiley   +1 more source

Concurrent Endometrial Carcinoma in Patients with a Curettage Diagnosis of Endometrial Hyperplasia

Journal of the Formosan Medical Association, 2009
Endometrial hyperplasia is considered a precursor of endometrial carcinoma, but concurrent endometrial carcinoma in patients with endometrial hyperplasia is seen frequently.
Yu-Li Chen, Wen-Fang Cheng, Ming-Chieh Lin, Chia-Yen Huang, Chang-Yao Hsieh, Chi-An Chen   +5 more
doaj   +1 more source

Germline predisposition and somatic mutational landscape in synchronous mucinous metaplasia and neoplasia of the female genital tract

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
Synchronous mucinous metaplasia and neoplasia of the female genital tract (SMMN‐FGT) is characterised by an enrichment of pathogenic germline variants in cancer‐predisposition genes, particularly BRCA1 and other homologous recombination repair genes. Recurrent TP53 mutations are concentrated in malignant lesions, while clonal and functional analyses ...
Ying Yuan, Li Zhang, Jiongbo Liao, Bo Wang, Linghui Lu, Dongchen Chu, Yue Shi, Jiaqi Liu, Feng Zhang, Shuyan Tang, Chao Wang   +10 more
wiley   +1 more source

Comparison of Frozen and Final Pathology Results in Patients Operated for Endometrial Hyperplasia

Gynecology Obstetrics & Reproductive Medicine
OBJECTIVE: Our study aimed to determine the frequency of endometrial cancer in patients undergoing surgery with a diagnosis of endometrial hyperplasia and to evaluate the concordance between preoperative diagnosis, frozen section examination, and final ...
Gonca Turker Ergun, Ugurcan Zorlu, Burak Elmas, Bengü Nur Baris Akcan, Gul Kurtaran, Kadir Cetinkaya, Melike Doganay   +6 more
doaj   +1 more source

Is Hypercortisolism Treatable? Which Patients Should Be Treated and How—A Practical Guide for Clinicians

Diabetes, Obesity and Metabolism, Volume 28, Issue S4, Page 34-49, August 2026.
ABSTRACT Aim To provide a practical guide on when to suspect endogenous hypercortisolism, how to use the overnight 1‐mg dexamethasone suppression test (DST) for targeted case‐finding, and which patients are most likely to benefit from treatment.
Juan Pablo Frias
wiley   +1 more source

Atypical endometrial hyperplasia in the conception of tumor progression (literature review)

Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье
Introduction. In recent years there has been an frequency increase of endometrial hyperplasia in the structure of gynecological morbidity. Atypical endometrial hyperplasia represents important clinical relevance in the basis of progression to endometrial
M. M. Damirov, G. P. Titova, A. P. Ierusalimskiy   +2 more
doaj   +1 more source

Treatment of atypical endometrial hyperplasia with an insulin-sensitizing agent

Gynecological Endocrinology, 2003
Endometrial cancer and hyperplasia have long been associated with diabetes. Hyperinsulinemia may have a direct mitogenic effect on the endometrium and may inhibit the effect of progestogen therapy. This case report describes the treatment of a patient with atypical endometrial hyperplasia with an insulin-sensitizing agent.
D R, Session, K R, Kalli, I S, Tummon, M A, Damario, D A, Dumesic   +4 more
openaire   +2 more sources

Association of Endometrial Hyperplasia with Some Risk Factors

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2009
BACKGROUND AND OBJECTIVE: Endometrial cancer is one of the most common invasive gynecologic malignancies. Abnormal uterine bleeding (AUB) is the most common symptom in endometrial hyperplasia. Women with AUB are examined with dilation and curettage (D;C)
R Faraji,, N Esmailpour, B Behfar
doaj  

CEBPB promotes transformation of endometrial complex atypical hyperplasia to endometrial cancer

BMC Cancer
As the precursor malignancy of endometrial cancer (EC), about 50% of endometrial complex atypical hyperplasia (CAH) will eventually progress to EC. Elucidating the underlying transformation mechanisms could aid in disease management.EC, CAH, reversed CAH and normal endometrium tissues were collected and sequenced to identify genes involved in the ...
Jiahong Tan, Lin Zhao, Daoqi Wang, Xiaodie Wu, Yongxiang Bi, Hanying Wang, Na Ma, Dehong Yang, Wei Dong, Jie Zhang   +9 more
openaire   +3 more sources