Results 71 to 80 of about 304,767 (203)

Bcl-2 May Contribute to Evolution of Endometrial Hyperplasia, but It Isn’t a Factor in Subsequent Carcinogenesis [PDF]

Archives of Razi Institute
Endometrial carcinoma is common in the western world and is increasing in frequency in developing countries as well. Endometrial hyperplasia is considered to be a precancerous lesion.
Athulya Krishna Kumar, Krishnaraj Upadhyaya, Ravi Teja CN   +2 more
doaj   +1 more source

Germline predisposition and somatic mutational landscape in synchronous mucinous metaplasia and neoplasia of the female genital tract

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
Synchronous mucinous metaplasia and neoplasia of the female genital tract (SMMN‐FGT) is characterised by an enrichment of pathogenic germline variants in cancer‐predisposition genes, particularly BRCA1 and other homologous recombination repair genes. Recurrent TP53 mutations are concentrated in malignant lesions, while clonal and functional analyses ...
Ying Yuan, Li Zhang, Jiongbo Liao, Bo Wang, Linghui Lu, Dongchen Chu, Yue Shi, Jiaqi Liu, Feng Zhang, Shuyan Tang, Chao Wang   +10 more
wiley   +1 more source

Is Hypercortisolism Treatable? Which Patients Should Be Treated and How—A Practical Guide for Clinicians

Diabetes, Obesity and Metabolism, Volume 28, Issue S4, Page 34-49, August 2026.
ABSTRACT Aim To provide a practical guide on when to suspect endogenous hypercortisolism, how to use the overnight 1‐mg dexamethasone suppression test (DST) for targeted case‐finding, and which patients are most likely to benefit from treatment.
Juan Pablo Frias
wiley   +1 more source

PINCH Protein Expression in Normal Endometrium, Atypical Endometrial Hyperplasia and Endometrioid Endometrial Carcinoma [PDF]

, 2010
Background: Particularly interesting new cysteine-histidine rich protein ( PINCH), as an adapter protein of the LIM family for signal transduction in the integrin and growth factor pathway, is upregulated in the stroma of several common types of cancers ...
Yan, Bao-Yong, Xia Zhang, Yan, Bao-Yong,, Zhang, Zhi-Yong, Zheng, Yan,, Hong-Zhen Zhang, Zhang, Hong-Zhen,, Zhen-Long Zhu, Sun, Xiao-Feng,, Huang, Li-Xia, Zhi-Yong Zhang, Ya-Li Meng, Xu, Shu-Wen, Meng, Ya-Li, Li, Xue-Hui, Zhu, Zhen-Long,, Xu, Shu-Wen,, Zheng, Yan, Cui, Dong-Sheng,, Zhu, Zhen-Long, Li, Xue-Hui,, Meng, Ya-Li,, Zhang, Hong-Zhen, Zhang, Xia, Cui, Dong-Sheng, Bao-Yong Yan, Zhang, Xia,, Xue-Hui Li, Li-Xia Huang, Xiao-Feng Sun, Zhang, Zhi-Yong,, Sun, Xiao-Feng, Shu-Wen Xu, Yan Zheng, Dong-Sheng Cui, Huang, Li-Xia,   +35 more
core   +1 more source

The Molecular Pathology of Morules in Endometrial Carcinoma: Biological Significance and Clinical Implications

Pathology International, Volume 76, Issue 8, August 2026.
In Em Ca cells with harboring baseline CTNNB1 mutations, morular‐ and SqM‐related CSCs and mature SqM components develop sequentially through tightly orchestrated EMT and MET programs, a cascade favored under microenvironmental hypoxia. Conversely, in Em Ca cells displaying wild‐type CTNNB1, the tumor cells directly trans‐differentiate into a squamous ...
Makoto Saegusa
wiley   +1 more source

Agreement level of preoperative histology with post-surgical histology in atypical hyperplasia and endometrial cancer patients [PDF]

Background: Endometrial cancer significantly contributes to gynecological cancers. The aim of the study was to assess the concordance between the preoperative endometrial biopsy and histology of hysterectomy specimens in patients surgically treated for ...
Toshyan, Varnit, Dalal, Venus, Asal, Raghda, Bharti, Shipra, Kumar, Vanitha   +4 more
core   +1 more source

Recurrent endometrial hyperplasia without atypia: how to escape the vicious circle?

, 2023
Today, endometrial hyperplasia (EH) is among the most relevant gynecological entities. Arterial hypertension, diabetes mellitus and obesity, the combination of which is referred to as metabolic syndrome, are the key risk factors of EH.
Irina A. Mullina, Mekan R. Orazov, Evgenii D. Dolgov, Viktor E. Radzinskii, Yuliia S. Artemenko, Marina B. Khamoshina   +5 more
core   +1 more source

Genetically Confirmed Osteogenesis Imperfecta (COL1A1) With Unexplained Ambiguous Genitalia in a 46,XY Child: An Index Case Report

Clinical Case Reports, Volume 14, Issue 7, July 2026.
A 6‐year‐old child with a rare dual diagnosis confirmed by genetic testing ‐ osteogenesis imperfecta (blue sclerae, disproportionate short stature) and concurrent 46,XY disorder of sex development (micropenis, hypospadias, impalpable gonads). ABSTRACT Osteogenesis imperfecta (OI) is a heritable disorder of type I collagen characterized by bone ...
Harshita Agarwal, Tathagata Jha, Mohammad Orooj Azmi, Soumita Sarkar, Vinay Suresh   +4 more
wiley   +1 more source

Comparison of Frozen and Final Pathology Results in Patients Operated for Endometrial Hyperplasia

Gynecology Obstetrics & Reproductive Medicine
OBJECTIVE: Our study aimed to determine the frequency of endometrial cancer in patients undergoing surgery with a diagnosis of endometrial hyperplasia and to evaluate the concordance between preoperative diagnosis, frozen section examination, and final ...
Gonca Turker Ergun, Ugurcan Zorlu, Burak Elmas, Bengü Nur Baris Akcan, Gul Kurtaran, Kadir Cetinkaya, Melike Doganay   +6 more
doaj   +1 more source

From Metabolic Crisis to Molecular Classification: Multidisciplinary Management of Synchronous Endometrioid Ovarian and Endometrial Carcinomas With Massive Tumor Burden

Cancer Nexus, Volume 2, Issue 3, July 2026.
Managing massive tumor burden in synchronous endometrioid carcinomas. The graphical abstract summarizes the clinical pathway from presentation with massive ascites, pleural effusion, and critical metabolic abnormalities to multidisciplinary stabilization, surgical management, integrated morphologic–molecular classification, and shared decision‐making ...
Anna Homeniuk, Leena Abdalla, Sharon Fitzgerald   +2 more
wiley   +1 more source