Results 181 to 190 of about 12,787 (210)

Atypical Hemolytic–Uremic Syndrome

New England Journal of Medicine, 2009
The hemolytic–uremic syndrome, which is characterized by nonimmune hemolytic anemia, thrombocytopenia, and renal impairment, occurs most frequently in young children. Most cases are secondary to infection with Escherichia coli O157:H7 and other Shiga-toxin–producing strains.
Marina Noris, Giuseppe Remuzzi
exaly   +3 more sources

Pathogenesis of Atypical Hemolytic Uremic Syndrome

Journal of Atherosclerosis and Thrombosis, 2019
Atypical hemolytic uremic syndrome (aHUS) is a type of thrombotic microangiopathy (TMA) defined by thrombocytopenia, microangiopathic hemolytic anemia, and renal failure. aHUS is caused by uncontrolled complement activation in the alternative pathway (AP).
Yoichirô Ikeda, Masaomi Nangaku
exaly   +4 more sources

Plasmatherapy in Atypical Hemolytic Uremic Syndrome

Seminars in Thrombosis and Hemostasis, 2010
Plasmatherapy has become empirically first-line treatment in atypical hemolytic uremic syndrome (aHUS), although no prospective controlled trials have been conducted. Patients with mutations that induce complete or partial factor H (FH) quantitative deficiency may be controlled by plasma infusions (PI), but plasma exchanges appear more efficient than ...
, Arnaud Garnier, Anne-Laure Sellier-Leclerc   +2 more
exaly   +3 more sources

Atypical hemolytic uremic syndrome

Current Opinion in Hematology, 2010
The last few years revealed a molecular distinction between thrombotic thrombocytopenic purpura, a disease characterized by a lack of ADAMTS13 activity, and atypical hemolytic uremic syndrome (aHUS), a disease of complement overactivation. Many different predisposing genetic factors resulting in complement overactivation have been described in aHUS ...
Kavanagh D, Goodship THJ
openaire   +3 more sources

Atypical hemolytic uremic syndrome

Pediatrics International, 1995
AbstractThe pathogenesis of atypical uremic syndrome (HUS), which is rarely encountered in childhood, is poorly understood and its mortality and morbidity rates are high. A wide variety of therapeutic approaches has been attempted and the literature contains numerous conflicting reports about the results of these approaches.
KAVUKÇU S., İRKEN G., OLGUN N., GÜÇLÜ A.   +3 more
openaire   +4 more sources

An Atypical Case of Atypical Hemolytic Uremic Syndrome

Journal of Pediatric Hematology/Oncology, 2019
We present the case of a 2-month-old infant presenting with pallor and laboratory results showing: hemoglobin 5.1 (10 to 1.5) g/dL, MCV 94.7 (75 to 105) fL, leukocytes 17.4 (7 to 15) ×103/μL, platelets 259 (150 to 450) ×103/μL, hyperbilirubinemia and renal dysfunction.
Tine, Francois, Johan, Vande Walle, Evelyn, Dhont, Werner, Keenswijk   +3 more
openaire   +2 more sources

Eculizumab for Atypical Hemolytic Uremic Syndrome in Pregnancy

Obstetrics & Gynecology, 2013
Atypical hemolytic uremic syndrome (HUS) is a thrombotic microangiopathy often caused by mutations in complement genes. During pregnancy, disease outcome is poor both for mother and fetus. Since 2009, the humanized monoclonal antibody eculizumab has been successfully used in the treatment of atypical HUS in nonpregnant patients.A 26-year-old woman with
G. Ardissino, M. W. Ossola, G.M. Baffero, A. Rigotti, M. Cugno   +4 more
openaire   +2 more sources

Skin Involvement in Atypical Hemolytic Uremic Syndrome

American Journal of Kidney Diseases, 2014
Skin involvement in atypical hemolytic uremic syndrome (aHUS) is very uncommon and therefore often unrecognized as a specific symptom of aHUS. We describe 3 cases of patients with aHUS who developed skin lesions that completely recovered when disease-specific treatment was established.
ARDISSINO, GIAN LUIGI, F. Tel, S. Testa, A. V. Marzano, R. Lazzari, S. Salardi, A. Edefonti   +6 more
openaire   +3 more sources

Atypical hemolytic uremic syndrome in the Tunisian population

International Urology and Nephrology, 2010
Hemolytic uremic syndrome consists of a triad of acquired hemolytic anemia, thrombocytopenia and renal failure.Our objectives were to determine epidemiology, clinical and laboratory characteristics of patients with atypical hemolytic uremic syndrome (aHUS) to determine the relationship between the complement protein deficit and aHUS in the Tunisian ...
Nadia, Leban, Sabra, Aloui, Dalel, Touati, Ramzy, Lakhdhar, Habib, Skhiri, Gerard, Lefranc, Abdellatif, Achour, Mezri, Elmay, Margarita, Lopez-Trascasa, Pilar, Sanchez-Corral, Jemni, Chibani, Amel, Haj Khelil   +11 more
openaire   +2 more sources

Posttransplant recurrence of atypical hemolytic uremic syndrome

Journal of Nephrology, 2012
Hemolytic uremic syndrome (HUS) is a rare disease characterized by microangiopathic hemolytic anemia, thrombocytopenia and acute renal failure. It is usually secondary to infections by strains of Escherichia coli (STEC) that produce Shiga-like toxin. In about 10% of patients, no STEC infections are reported.
Elisabetta, Valoti, Marta, Alberti, Marina, Noris   +2 more
openaire   +2 more sources