Results 51 to 60 of about 24,893 (251)

How I treat thrombotic thrombocytopenic purpura and atypical haemolytic uraemic syndrome [PDF]

, 2014
Thrombotic thrombocytopenic purpura (TTP) and atypical haemolytic uraemic syndrome (aHUS) are acute, rare life-threatening thrombotic microangiopathies that require rapid diagnosis and treatment.
Goodship, T, Scully, M
core   +1 more source

Atypical Hemolytic Uremic Syndrome: A Review of Complement Dysregulation, Genetic Susceptibility and Multiorgan Involvement. [PDF]

J Clin Med
Atypical hemolytic uremic syndrome (aHUS) is a rare, life-threatening thrombotic microangiopathy (TMA) characterized by complement dysregulation, leading to microvascular thrombosis and multi-organ injury.
Bogdan RG, Anderco P, Ichim C, Cimpean AM, Todor SB, Glaja-Iliescu M, Crainiceanu ZP, Popa ML.   +7 more
europepmc   +2 more sources

Clinical characteristics and outcomes of a patient population with atypical hemolytic uremic syndrome and malignant hypertension: analysis from the Global aHUS registry

JN. Journal of Nephrology (Milano. 1992), 2022
Introduction Atypical hemolytic uremic syndrome (aHUS) is a rare form of thrombotic microangiopathy (TMA) often caused by alternative complement dysregulation.
J. Halimi, I. Al-Dakkak, K. Anokhina, G. Ardissino, C. Licht, W. Lim, A. Massart, F. Schaefer, J. Walle, E. Rondeau   +9 more
semanticscholar   +1 more source

Phenotypic manifestation of homozygous partial deletion of the chromosome 1 segment spanning CFHR3 region

Медицинская иммунология, 2020
This article presents two clinical cases of patients with a homozygous deletion of segment of chromosome 1, which covers regions of genes associated with complement factor H, in particular CFHR3.
I. A. Tuzankina, M. A. Bolkov, N. S. Zhuravleva, Yu. O. Vaseneva, Kh. Shinvari, O. V. Schipacheva   +5 more
doaj   +1 more source

Hemolytic uremic syndrome (HUS) – case report

Journal of Education, Health and Sport, 2020
Introduction Hemolytic uremic syndrome (HUS) is characterized by hemolytic anemia, thrombocytopenia and acute renal failure. In 90% of children, HUS most often develops after an intestinal infection caused by verotoxin-producing E. coli. The remaining 10%
Aleksandra Borkowska, Anna Sobstyl, Aleksandra Chałupnik, Zuzanna Chilimoniuk, Maciej Dobosz, Szymon Marosz   +5 more
doaj   +1 more source

Atypical hemolytic-uremic syndrome in children

Инновационная медицина Кубани, 2022
Background: Atypical hemolytic-uremic syndrome (aHUS) is a rare progressive form of systemic thrombotic microangiopathy (TMA), which develops due to uncontrolled activation of the alternative pathway of the complement system and is characterized by a ...
A. V. Burlutskaya, A. V. Statova, D. V. Ustyuzhaninа, Yu. V. Pisotskaya   +3 more
doaj   +1 more source

Small-molecule factor D inhibitors selectively block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome

Haematologica, 2017
Paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome are diseases of excess activation of the alternative pathway of complement that are treated with eculizumab, a humanized monoclonal antibody against the terminal complement ...
Xuan Yuan, Eleni Gavriilaki, Jane A. Thanassi, Guangwei Yang, Andrea C. Baines, Steven D. Podos, Yongqing Huang, Mingjun Huang, Robert A. Brodsky   +8 more
doaj   +1 more source

Thrombotic microangiopathy and associated renal disorders [PDF]

, 2012
Thrombotic microangiopathy (TMA) is a pathological process involving thrombocytopenia, microangiopathic haemolytic anaemia and microvascular occlusion.
Barbour, T, Cohney, S, Hughes, P, Johnson, S   +3 more
core   +1 more source

Functional Analysis of Variants in Complement Factor I Identified in Age-Related Macular Degeneration and Atypical Hemolytic Uremic Syndrome

Frontiers in Immunology, 2022
Complement factor I (FI) is a central inhibitor of the complement system, and impaired FI function increases complement activation, contributing to diseases such as age-related macular degeneration (AMD) and atypical hemolytic uremic syndrome (aHUS ...
Sarah de Jong, Anita de Breuk, Bjorn Bakker, S. Katti, C. Hoyng, Sara C. Nilsson, A. Blom, L. P. van den Heuvel, A. D. den Hollander, E. Volokhina   +9 more
semanticscholar   +1 more source

Atypical hemolytic uremic syndrome: diagnosis, management, and discontinuation of therapy. [PDF]

Hematology Am Soc Hematol Educ Program
Atypical hemolytic uremic syndrome (aHUS) is a thrombotic microangiopathy typically characterized by anemia, thrombocytopenia, and end-organ injury. aHUS occurs due to endothelial injury resulting from overactivation of the alternative pathway of the ...
Java A.
europepmc   +2 more sources