Results 41 to 50 of about 24,893 (251)

Atypical Hemolytic Uremic Syndrome

Pediatric Clinics of North America, 2018
Atypical hemolytic uremic syndrome is a rare life-threatening disease of unregulated complement activation. Untreated, the prognosis is generally poor; more than one-half of patients die or develop end-stage renal disease within 1 year. Atypical hemolytic uremic syndrome is characterized by thrombotic microangiopathy with evidence of hemolysis ...
Bradley P. Dixon, Ralph A. Gruppo
  +7 more sources

Serological and genetic complement alterations in infection-induced and complement-mediated hemolytic uremic syndrome [PDF]

, 2016
Background: The role of complement in the atypical form of hemolytic uremic syndrome (aHUS) has been investigated extensively in recent years. As the HUS-associated bacteria Shiga-toxin-producing Escherichia coli (STEC) can evade the complement system ...
Bakker, J.A. (Jaap), Bouts, A.H. (Antonia), Dorresteijn, E.M. (Eiske), Goertz, J. (Joop), Gracchi, V. (Valentina), Heuvel, L.P. (Lambert) van den, Jeronimus-Klaasen, A. (Annelies), Kar, N.C. (Nicole) van de, Keijzer-Veen, M.G. (Mandy), Roos, A. (Anja), van der Molen, R.G. (Renate G.), van der Velden, T.J.A.M. (Thea J. A. M.), van Wijk, J.A.E. (Joanna A. E.), Volokhina, E.B. (Elena), Westra, D.F.   +14 more
core   +9 more sources

Hemolytic uremic syndrome related to Shiga-like toxin-producing Escherichia coli with encephalitis hiding a human herpesvirus-6 infection: a case report

Journal of Medical Case Reports, 2021
Background Cardiac and neurological involvement in hemolytic uremic syndrome are life-threatening complications. The most frequent complications of cardiac involvement in hemolytic uremic syndrome are myocarditis and cardiac dysfunction due to fluid ...
Sophie Mounier, Arthur Gavotto, Julie Tenenbaum, Pierre Meyer, Marc Fila, Julien Baleine   +5 more
doaj   +1 more source

Atypical hemolytic uremic syndrome

Journal of Allergy and Clinical Immunology
Hemolytic uremic syndromes are a heterogeneous group of conditions with differing underlying pathophysiology. These all result in pathologic features of thrombotic microangiopathy (TMA), which cause endothelial damage and organ injury. TMAs manifest with a microangiopathic hemolytic anaemia, thrombocytopenia, and commonly acute kidney injury.
Patrick R. Walsh, David Kavanagh
  +5 more sources

Atypical Hemolytic Uremic Syndrome

Seminars in Nephrology, 2013
Hemolytic uremic syndrome (HUS) is a triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. The atypical form of HUS is a disease characterized by complement overactivation. Inherited defects in complement genes and acquired autoantibodies against complement regulatory proteins have been described.
Kavanagh D, Goodship TH, Richards A
openaire   +4 more sources

Overlapping Atypical Hemolytic Uremic Syndrome and C3 Glomerulopathy with Mutation in CFI in a Japanese Patient: A Case Report

Internal medicine, 2023
A 34-year-old Japanese man presented with blurred vision, headache, nausea, anemia, thrombocytopenia, and severe renal dysfunction. Thrombotic microangiopathy was initially suspected to have been caused by malignant hypertension.
Kosuke Osawa, Shuto Yamamoto, Yukiko Yamano, Ayako Kita, Kota Okamoto, Noritoshi Kato, Yoshitaka Tatematsu, F. Kojima, Masaki Ohya, Shigeo Hara, Shin-ichi Murata, Norimitsu Inoue, S. Maruyama, Shin-ichi Araki   +13 more
semanticscholar   +1 more source

Anti-factor H antibody and its role in atypical hemolytic uremic syndrome

Frontiers in Immunology, 2022
Atypical hemolytic uremic syndrome (aHUS) an important form of a thrombotic microangiopathy (TMA) that can frequently lead to acute kidney injury (AKI). An important subset of aHUS is the anti-factor H associated aHUS.
R. Raina, Guneive Mangat, Gordon Hong, R. Shah, N. Nair, Brian Abboud, Sumedha Bagga, S. Sethi   +7 more
semanticscholar   +1 more source

Cutaneous and renal glomerular vasculopathy as a cause of acute kidney injury in dogs in the UK [PDF]

, 2015
To describe the signalment, clinicopathological findings and outcome in dogs presenting with acute kidney injury (AKI) and skin lesions between November 2012 and March 2014, in whom cutaneous and renal glomerular vasculopathy (CRGV) was suspected and ...
ARDISSINO, ARDISSINO, ARONSON, BIRNBAUM, BLOMBERY, BOURHY, BOYCE, BURNENS, CARPENTER, CHANTREY, COWAN, DELL'ORCO, DICKINSON, EUBIG, FERRER, FISCHER, FOURNEL, GARCIA, GOLDFARB, GREENE, HENDRICKS, HERTZKE, HOLLOWAY, KAVANAGH, LI, MILFORD, MONAHAN, MOORE, MORRIS, MUNDAY, NORIS, PASS, REBAR, RENTKO, ROBY, ROTERMUND, RUGGENENTI, SALVADORI, SYKES, TANGEMAN, TARR, TARR, UCHIDA, VAN DEN INGH, VICTORIA, WAIKAR, WALKER   +46 more
core   +1 more source

Atypical hemolytic uremic syndrome and C3 glomerulopathy: conclusions from a "Kidney Disease: Improving Global Outcomes" (KDIGO) Controversies Conference.

Kidney International, 2017
In both atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G) complement plays a primary role in disease pathogenesis. Herein we report the outcome of a 2015 Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference where
T. Goodship, H. Cook, F. Fakhouri, F. Fervenza, V. Frémeaux-Bacchi, D. Kavanagh, C. Nester, M. Noris, M. Pickering, S. R. Córdoba, L. Roumenina, L. Roumenina, L. Roumenina, S. Sethi, Richard J. H. Smith, C. Alpers, G. Appel, G. Ardissino, G. Ariceta, M. Arıcı, A. Bagga, I. Bajema, M. Blasco, Linda Burke, T. Cairns, M. Carratalá, V. D’Agati, M. Daha, A. S. Vriese, M. Dragon-Durey, A. Fogo, M. Galbusera, D. Gale, Hermann Haller, Sally Johnson, M. Józsi, D. Karpman, Lynne Lanning, M. L. Quintrec, C. Licht, C. Loirat, F. Monfort, B. Morgan, L. Noël, M. O'shaughnessy, M. Rabant, E. Rondeau, P. Ruggenenti, N. Sheerin, J. Smith, Fabrizio Spoleti, J. Thurman, N. Kar, M. Vivarelli, P. Zipfel   +54 more
semanticscholar   +1 more source

Long-Term Efficacy and Safety of the Long-Acting Complement C5 Inhibitor Ravulizumab for the Treatment of Atypical Hemolytic Uremic Syndrome in Adults

Kidney International Reports, 2021
Introduction Atypical hemolytic uremic syndrome (aHUS) is a rare, complex, multisystem disease of dysregulated complement activity, characterized by progressive thrombotic microangiopathy (TMA), acute kidney injury, and multiorgan dysfunction, which ...
T. Barbour, M. Scully, G. Ariceta, S. Cataland, Katherine Garlo, N. Heyne, Y. Luque, J. Menne, Y. Miyakawa, S. Yoon, D. Kavanagh, Sunil Nilufer Nicole Fiona Philip Josep M. Paramit Theo Babu Broeders Lietar Brown Campbell Campistol Chow, S. Babu, Nilufer Broeders, N. Lietar, F. Brown, P. Campbell, J. Campistol, P. Chowdhury, T. Kasimatis, L. Cirami, L. Caroti, Guilia Antognoli, Yahsou Delmas, V. Dobronravov, Anja Gaeckler, C. Garrouste, G. Greenwood, S. Griffin, Chiu-Ching Huang, I. Chen, Susan Huang, Jin Seok Kim, G. La Manna, M. Le Quintrec, Guillaume Jeantet, Iino Fumie, E. Rondeau, H. Haller, J. Morelle, É. Goffin, Anja Muhlfeld, S. Nagaraj, G. Arepally, D. Oh, M. Okumi, Manuel Praga Terente, F. Provôt, U. Schönermarck, M. Fischereder, N. Terrada, B. Seitz-Polski, G. Favre, Sonia Boyer-Suavet, M. Vinogradova, T. Kirsanova, E. Wong   +56 more
semanticscholar   +1 more source