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‘Atypical’ Parkinson's disease – genetic
2019Genetic atypical Parkinson's disease (PD) describes monogenic forms of PD that resemble idiopathic PD but feature prominent atypical clinical signs and symptoms and can be sub-grouped into i) atypical monogenic forms caused by mutations in the ATP13A2, DNAJC6, FBXO7, SYNJ1, VPS13C, and DCTN genes; ii) monogenic PD more closely resembling idiopathic PD,
Anne, Weissbach +3 more
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‘Atypical’ Parkinson's disease – sporadic
2019Parkinson's disease still is a clinical diagnosis. Also, the MDS Clinical Diagnostic Criteria for Parkinson's disease published in 2015 are based on clinical characteristics and were designed codifying the diagnostic process of an expert. The purpose was to support less experienced neurologists to achieve the diagnostic procedure up to the level of an ...
Kirsten E, Zeuner, Daniela, Berg
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SPECT and PET in Atypical Parkinsonism
PET Clinics, 2010Parkinson disease (PD) is the prototypic movement disorder originally described by James Parkinson, and it accounts for about 80% of a group of related degenerative motor disorders collectively referred to as the parkinsonisms, Parkinson spectrum disorders, or Parkinson plus disorders, terms which are used interchangeably throughout this article.
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Structural Imaging in Atypical Parkinsonism
2018Qualitative and quantitative structural magnetic resonance imaging offer objective measures of the underlying neurodegeneration in atypical parkinsonism. Regional changes in tissue volume, signal changes and increased deposition of iron as assessed with different structural MRI techniques are surrogate markers of underlying neurodegeneration and may ...
Beatrice, Heim +2 more
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Dementia in Parkinson’s Disease and Atypical Parkinsonism
2014Parkinson’s disease (PD) is the second most common neurodegenerative disorder, after Alzheimer’s disease. The prevalence of Parkinson’s disease dementia (PDD) is roughly estimated to be around 30 %, while PDD will occur in over 80 % of patients after 20 years of disease, conferring an important impact on patient management and prognosis.
Maria Stamelou, Kailash Bhatia
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Typical atypical or atypical atypical Parkinsonism?
Parkinsonism & Related Disorders, 2016Stephanie T. Hirschbichler +4 more
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Genetics of Atypical Parkinsonism
2005Parkinson’s disease (PD) is traditionally defined as a clinico-pathologic entity, characterized by a core syndrome of akinesia, rigidity, tremor, and postural instability, and pathologically by a more or less selective degeneration of dopaminergic neurons of the substantia nigra, leading to a deficiency of dopamine in the striatal projection areas of ...
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[Atypical Parkinson syndrome].
Der Nervenarzt, 1997Various clinico-pathological studies have shown that appr. 20% of patients with a clinical diagnosis of idiopathic Parkinson's disease (IPD) may have neuropathological evidence of alternative causes of parkinsonism. Most of these misdiagnosed "IPD" patients meet clinical criteria for either multiple system atrophy (MSA), or progressive supranuclear ...
G K, Wenning +3 more
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