Results 71 to 80 of about 69,209 (245)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Structural analysis of $$\hbox{Sn}$$ on $${\hbox{Au}(111)}$$ at low coverages: Towards the $${\hbox {Au}_{2}\hbox {Sn}}$$ surface alloy with alternating fcc and hcp domains

Scientific Reports
We report on the structural and chemical evolution of submonolayer $$\hbox{Sn}$$ on $${\hbox{Au}(111)}$$ up to the formation of the striped $${\hbox {Au}_{2}\hbox {Sn}}$$ surface alloy.
Julian A. Hochhaus, Stefanie Hilgers, Marie Schmitz, Lukas Kesper, Ulf Berges, Carsten Westphal   +5 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Dissociative Adsorption of O₂ on Ag₃Au(111) Surface: A Density Functional Theory Study

Crystals
The catalytic efficiency of oxygen reduction catalysts is notably influenced by the dissociative adsorption of O2. We conducted a systematic investigation into the dissociative adsorption of O2 on the Ag3Au(111) surface using ab initio density functional
Yanlin Yu, Mingan Fu, Huaizhang Gu, Lei Wang, Wanxiu Liu, Qian Xie, Guojiang Wu   +6 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Fabricating model heterostructures of large-area monolayer or bilayer MoS2 on an Au(111) surface under ultra-high vacuum

Results in Physics
Fabricating heterojunctions with precisely controlled interfacial structures is crucial for exploring novel low-dimensional physics and for realizing high-performance devices.
Bingrui Li, Weiwei Huang, Chaoqi Dai, Boyuan Wen, Yan Shen, Fei Liu, Ningsheng Xu, Fangfei Ming, Shaozhi Deng   +8 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Porphine Homocoupling on Au(111)

The Journal of Physical Chemistry C, 2019
The covalent coupling of porphine molecules on Au(111) is studied by scanning probe microscopy experiments and density functional theory.
K. Seufert, F. McBride, S. Jaekel, B. Wit, S. Haq, A. Steiner, P. Poli, M. Persson, R. Raval, L. Grill   +9 more
openaire   +1 more source

First-principles insights into NO electroreduction on Ti- and Co-doped Au(111) monolayers: Structural reconstruction, electronic synergy, and reaction mechanism

Materials & Design
In this work, we employed density functional theory (DFT) calculations to investigate the structural, electronic, and catalytic properties of Ti- and Co-doped Au(111) monolayers as electrocatalysts for NO electroreduction.
Guozheng Zhao, Fang Yuan, Chaozheng He
doaj   +1 more source