Results 11 to 20 of about 4,379 (211)
Frontiers in Neuroscience, 2022 Presbycusis and tinnitus are the two most common hearing related pathologies. Although both of these conditions presumably originate in the inner ear, there are several reports concerning their central components.
Jakub Fuksa +10 more
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Ageing and the auditory system [PDF]
Postgraduate Medical Journal, 2006 Abstract There are a number of pathophysiological processes underlying age related changes in the auditory system. The effects of hearing loss can have consequences beyond the immediate loss of hearing, and may have profound effects on the functioning of the person.
A, Howarth, G R, Shone
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Frontiers in Neural Circuits, 2021 Dopamine (DA) modulates the activity of nuclei within the ascending and descending auditory pathway. Previous studies have identified neurons and fibers in the inferior colliculus (IC) which are positively labeled for tyrosine hydroxylase (TH), a key ...
Sharonda Harris +6 more
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Bilirubin and the Auditory System [PDF]
Journal of Perinatology, 2001 The auditory system is highly sensitive to bilirubin toxicity. Damage to the auditory nervous system includes auditory neuropathy or auditory dyssynchrony and auditory processing problems which may occur with or without deafness, hearing loss. Auditory dysfunction may occur in children with or without other signs of classical kernicterus.
S M, Shapiro, H, Nakamura
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eLife, 2022 Before hearing onset (postnatal day 12 in mice), inner hair cells (IHCs) spontaneously fire action potentials, thereby driving pre-sensory activity in the ascending auditory pathway.
Alena Maul +6 more
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Cochlear Inflammaging in Relation to Ion Channels and Mitochondrial Functions
Cells, 2021 The slow accumulation of inflammatory biomarker levels in the body—also known as inflammaging—has been linked to a myriad of age-related diseases. Some of these include neurodegenerative conditions such as Parkinson’s disease, obesity, type II diabetes ...
Parveen Bazard +10 more
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Frontiers in Cell and Developmental Biology, 2022 Neuronal development in the inner ear is initiated by expression of the proneural basic Helix-Loop-Helix (bHLH) transcription factor Neurogenin1 that specifies neuronal precursors in the otocyst.
Iva Filova +5 more
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The Kinocilia of Cochlear Hair Cells: Structures, Functions, and Diseases
Frontiers in Cell and Developmental Biology, 2021 Primary cilia are evolutionarily conserved and highly specialized organelles that protrude from cell membranes. Mutations in genes encoding ciliary proteins can cause structural and functional ciliary defects and consequently multiple diseases ...
Difei Wang, Jun Zhou, Jun Zhou
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A review of the mechanisms underlying the role of the GIPC3 gene in hereditary deafness
Frontiers in Synaptic Neuroscience, 2023 The GAIP interacting protein c terminus (GIPC) genes encode a small family of proteins characterized by centrally located PDZ domains. GIPC3 encodes a 312 amino acid protein. Variants of human GIPC3 are associated with non-syndromic hearing loss.
Xinxin Li, Lin Shi, Liang Wang
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The human auditory system and audio
Applied Acoustics, 2023 This work reviews the human auditory system, elucidating some of the specialized mechanisms and non-linear pathways along the chain of events between physical sound and its perception. Customary relationships between frequency, time, and phase--such as the uncertainty principle--that hold for linear systems, do not apply straightforwardly to the ...
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