Results 11 to 20 of about 1,201 (149)

Phosphinegold(I) Thiolates – Pharmacological Use and Potential [PDF]

, 2002
A brief overview of the use of gold compounds in medicine, namely in the treatment of rheumatoid arthritis is presented, including that of the orally-administered triethylphosphinegold(I) tetraacetylatedthioglucose species, auranofin.
Tiekink, Edward R. T.
core   +5 more sources

Harnessing Organometallic Au(III) Complexes as Precision Scaffolds for Next-Generation Therapeutic and Imaging Agents. [PDF]

Chembiochem
Cyclometalated gold(III) complexes offer a versatile platform for selective biological interactions, including cysteine arylation, redox modulation, and enzyme inhibition. This review explores their roles in anticancer, antimicrobial, and protein modification strategies, highlighting their ability to disrupt metabolic pathways, modulate aquaporins, and
Thomas SR, Bonsignore R.
europepmc   +2 more sources

DP1 Receptor Blockade Attenuates Microglial Senescence and Cognitive Decline Caused by PTGDS in Exosomes From Aged Brains. [PDF]

Aging Cell
DP1 receptor blockade attenuates microglial senescence and cognitive decline caused by PTGDS in exosomes from aged brains. ABSTRACT Aging leads to neurodegenerative diseases, such as cognitive decline, which are induced by persistent chronic low‐grade inflammation in the brain driven by microglial activation.
Liu Y, Liao P, Yan B, Li D, Zhang S, Zhang W, Jia Z, Zhang Z, Gao H, Liu Q, Chen F, Lei P, Yin Z.   +12 more
europepmc   +2 more sources

Disruption of disulfides within RBD of SARS-CoV-2 spike protein prevents fusion and represents a target for viral entry inhibition by registered drugs. [PDF]

FASEB J, 2021
Abstract The SARS‐CoV‐2 pandemic imposed a large burden on health and society. Therapeutics targeting different components and processes of the viral infection replication cycle are being investigated, particularly to repurpose already approved drugs. Spike protein is an important target for both vaccines and therapeutics.
Manček-Keber M, Hafner-Bratkovič I, Lainšček D, Benčina M, Govednik T, Orehek S, Plaper T, Jazbec V, Bergant V, Grass V, Pichlmair A, Jerala R.   +11 more
europepmc   +2 more sources

Gold Complexes in Anticancer Therapy: From New Design Principles to Particle‐Based Delivery Systems

Angewandte Chemie, Volume 135, Issue 22, May 22, 2023., 2023
Gold compounds have attracted considerable interest as anticancer drugs. However, the clinical translation of this class of compounds is hampered by suboptimal pharmacological performance. To address this problem, strategies based on molecular design principles have been the primary focus.
Guillermo Moreno‐Alcántar, Pierre Picchetti, Angela Casini   +2 more
wiley   +2 more sources

The zinc finger domains of PARP-1 are selectively and potently inhibited by the Au(I)-based drugs sodium aurothiomalate and aurothioglucose. [PDF]

FEBS Lett
Poly(ADP‐ribose) polymerase‐1 (PARP‐1) is a multidomain enzyme essential for the DNA damage response; its inhibition can lead to cancer cell death. Recruitment of PARP‐1 to sites of genomic damage is mediated by its zinc finger domains. In this study, we
Bashtanova U, Duer MJ.
europepmc   +3 more sources

Chemical Structure Elucidation in the Development of Inorganic Drugs: Evidence from Ru-, Au-, As-, and Sb-based Medicines. [PDF]

Eur J Inorg Chem
The importance of molecular structure elucidation in medicinal inorganic chemistry drug development is discussed and illustrated using three vignettes on Ru‐, Au‐, and As‐based drugs. An outlook on Sb‐based drugs is provided. The development of three classes of medicinal inorganic compounds is reviewed, highlighting the important role of structure ...
Lance-Byrne A, Lindquist-Kleissler B, Johnstone TC.   +2 more
europepmc   +2 more sources

Alzheimer's disease brain‐derived extracellular vesicles reveal altered synapse‐related proteome and induce cognitive impairment in mice

Alzheimer's &Dementia, Volume 19, Issue 12, Page 5418-5436, December 2023., 2023
Abstract INTRODUCTION Extracellular vesicles (EVs) have been implicated in the spread of neuropathology in Alzheimer's disease (AD), but their involvement in behavioral outcomes linked to AD remains to be determined. METHODS EVs isolated from post mortem brain tissue from control, AD, or frontotemporal dementia (FTD) donors, as well as from APP/PS1 ...
Victor Bodart‐Santos, Lisandra S. Pinheiro, Almir J. da Silva‐Junior, Rudimar L. Froza, Rosemary Ahrens, Rafaella A. Gonçalves, Mayara M. Andrade, Yan Chen, Carolina de Lima Alcantara, Lea T. Grinberg, Renata E. P. Leite, Sergio T. Ferreira, Paul E. Fraser, Fernanda G. De Felice   +13 more
wiley   +1 more source

Noncompartmental pharmacokinetics of three intravenous mycophenolate mofetil concentrations in healthy Standardbred mares

Veterinary Dermatology, Volume 34, Issue 3, Page 222-234, June 2023., 2023
Background – Mycophenolate mofetil (MMF) is the prodrug of mycophenolic acid (MPA) which acts as an immunosuppressive agent. During the biotransformation of MMF to MPA, additional metabolites including MPA phenol glucuronide (MPAG), MPA acyl glucuronide (AcMPAG) and MPA phenol glucoside (MPG) are formed.
Dylan L. Burroughs, Gwendolen Lorch, Yizhen Guo, Kasey Hill, Eric L. Schroeder, Lynette K. Cole, Mitch A. Phelps   +6 more
wiley   +1 more source

Prednisone treatment of elderly-onset rheumatoid arthritis: Disease activity and bone mass in comparison with chloroquine treatment [PDF]

, 1995
Objective. Prednisone is frequently used in the treatment of elderly-onset rheumatoid arthritis (RA), but the balance between efficacy and toxicity, including the effect on bone mass, has not been investigated in long-term studies.
Breedveld, F.C. (Ferdinand), Dijkmans, B.A.C. (Ben), Han, K.H. (Hubert), Papapoulos, S.E. (Socrates), Pauwels, E.K.J. (Ernest K.J), Schaardenburg, D. (Dirkjan) van, Valkema, R. (Roelf), Zwinderman, A.H. (Ailko)   +7 more
core   +10 more sources