Results 91 to 100 of about 2,279,222 (327)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Security flaws and improvement to a wireless authentication protocol with anonymity
Tongxin xuebao, 2006 The anonymous security flaw of an authentication protocol with anonymity for wireless networks which was proposed by Zhu, et al. was analyzed, and an improved protocol to a wireless authentication protocol with anonymity （IWAA） was proposed.
PENG Hua-xi, FENG Deng-guo
doaj +2 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
New low-earth orbit satellites authentication and group key agreement protocol
Tongxin xuebao, 2018 Due to the function of communication and continuous monitoring,the low-earth orbit satellites are widely used in the aerospace field.However,there is no special authentication protocol in the existing satellite communication system.In order to solve this
Zijian ZHANG +5 more
doaj +2 more sources
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Openstack authentication protocol based on digital certificate
Tongxin xuebao, 2019 As the industry standard for open source cloud platforms,openstack uses the single-factor authentication method based on username and password that provides by keystone components to identity authentication mechanism,while it is not suitable for ...
Zhiqiang ZHU, Renhao LIN, Cuiyun HU
doaj +2 more sources
Authentication Based on Multilayer Clustering in Ad Hoc Networks
EURASIP Journal on Wireless Communications and Networking, 2005 In this paper, we describe a secure cluster-routing protocol based on a multilayer scheme in ad hoc networks. This work provides scalable, threshold authentication scheme in ad hoc networks.
Suh Heyi-Sook +4 more
doaj