Results 91 to 100 of about 251,382 (296)

Putting the substance in substantial evidence: an evidence-based approach to flexible drug regulation

Frontiers in Medicine
For new drugs or indications, substantial evidence of clinical effectiveness is required for market authorization. In most jurisdictions, substantial evidence is not explicitly defined.
Emanuel Krebs, Tania Bubela, Melanie McPhail, Christopher McCabe, Dean A. Regier, Dean A. Regier   +5 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

THE IMPACT OF AUTHORIZATION IN THE ASSESSMENT OF RISKS AND SAFETY MEASURES OF OVERSIZED TRANSPORT ACTIVITY

Journal of Social Sciences
The article aims to analyze the regulations and regulatory framework regarding the authorization of oversized transport, highlighting their importance in ensuring road safety and protecting the infrastructure.
GARSTEA, Nina
doaj   +1 more source

Interest-Based Access Control for Content Centric Networks (extended version)

, 2015
Content-Centric Networking (CCN) is an emerging network architecture designed to overcome limitations of the current IP-based Internet. One of the fundamental tenets of CCN is that data, or content, is a named and addressable entity in the network ...
Ghali, Cesar, Schlosberg, Marc A., Tsudik, Gene, Wood, Christopher A.   +3 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Interoperable geographically distributed astronomical infrastructures: technical solutions [PDF]

, 2017
The increase of astronomical data produced by a new generation of observational tools poses the need to distribute data and to bring computation close to the data.
Bertocco, Sara, Dowler, Patrick, Gaudet, Séverin, Major, Brian, Pasian, Fabio, Taffoni, Giuliano   +5 more
core   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Property Is a Two-Way Street: Personal Copyright Use and Implied Authorization [PDF]

, 2011
When we use the Internet, we know that copyright law limits our freedom. We know, for example, that downloading popular music is legally risky. Those who want to get moralistic about it argue that illegal downloading violates a property right of the ...

core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source