Results 121 to 130 of about 518,369 (337)

Metabolic Imbalance Triggers Adaptive Remodeling to Accelerate Diploidization in Murine Haploid Embryonic Stem Cells

open access: yesAdvanced Science, EarlyView.
In this article, Shuai and colleagues demonstrate that metabolic remodeling drives self‐diploidization in murine haploid ESCs (haESCs). Mitochondrial dysfunction and imbalanced pyruvate metabolism underlie this process. Genome‐wide screening using haESCs identifies key mitochondrial quality‐control related genes, enabling a metabolism‐based medium that
Yi Fu   +11 more
wiley   +1 more source

Optimising child accident research outcomes: An action research project on maximising the dissemination and implementation of the Summer Research Scholarship Project reports and recommendations of the Child Accident Prevention Foundation of New Zealand [PDF]

open access: yes, 2004
A key objective of the Child Accident Prevention Foundation of New Zealand (hereafter referred to as "CAPFNZ" or "the Foundation") is to reduce the incidence and severity of child accidents.
Cowley, Natalie Anne   +3 more
core   +1 more source

PerfWeb: How to Violate Web Privacy with Hardware Performance Events

open access: yes, 2017
The browser history reveals highly sensitive information about users, such as financial status, health conditions, or political views. Private browsing modes and anonymity networks are consequently important tools to preserve the privacy not only of ...
A Tang   +8 more
core   +1 more source

Secure Architecture for E-commerce Websites Authors

open access: yes, 2019
With the rapid growth of Information Technology (IT), the current markets are being transformed into e-markets/ecommerce. This has created a need for a secure approach to implement e-commerce and to keep its security. To meet this need, Service Oriented Architecture (SOA), is one of the best proficiencies to opt to, because it is flexible and easy to ...
openaire   +1 more source

EEPD1 Inhibition Unleashes Antitumor Immunity in Colorectal Cancer by Activating the cGAS‐STING Pathway

open access: yesAdvanced Science, EarlyView.
In colorectal cancer, high expression of the DNA repair protein EEPD1 correlates with immune exclusion and poor prognosis. This study demonstrates that EEPD1 depletion induces genomic instability, leading to cytosolic DNA accumulation and subsequent activation of the cGAS‐STING‐type I interferon pathway. This cascade remodels the tumor microenvironment
Liyun Huo   +8 more
wiley   +1 more source

Picture Perfect: An Analysis of Diversity, Equity, and Inclusion in Orthopaedic Sports Medicine Website Imagery and Language

open access: yesJBJS Open Access
Background:. Diversity, equity, and inclusion (DEI) is important on patient-facing orthopaedic websites for patients to connect with healthcare providers. Image representation and language availability on websites allow for improved patient outcomes. The
Katarina Nilsson, BS   +6 more
doaj   +1 more source

SAA/FPR2 Signaling Between Pericentral Hepatocytes and Macrophages Exacerbates Zonated Liver Transplant Injury

open access: yesAdvanced Science, EarlyView.
After liver transplantation, ischemia‐reperfusion injury is more severe in pericentral regions. Multiomic analyses of human grafts and mouse models identify FOXO1 activation in pericentral hepatocytes as an upstream driver of SAA secretion. SAA recruits and activates FPR2+ macrophages, amplifying local inflammation. Amilo‐5MER inhibits SAA bioactivity,
Feng Zhang   +19 more
wiley   +1 more source

MEOX1 Coordinates Autocrine‐Paracrine Programs via SPHK1/S1P to Promote Lymph Node Metastasis in Ovarian Cancer

open access: yesAdvanced Science, EarlyView.
In ovarian cancer, MEOX1 activates the SPHK1/S1P pathway to promote both tumor progression and tumor–stroma crosstalk. MEOX1‐dependent signaling drives CAF activation, enhances VEGF‐C expression, and stimulates lymphangiogenesis, ultimately facilitating lymph node metastasis.
Jiajia Li   +10 more
wiley   +1 more source

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