Results 131 to 140 of about 237,743 (361)
Distribution of Certain Autoantibodies in Monozygotic and Dizygotic Twins [PDF]
W. Watson Buchanan+6 more
openalex +1 more source
Objective To compare the efficacy of abatacept to placebo for the treatment of relapsing, non‐severe granulomatosis with polyangiitis (GPA). Methods In this multicenter trial, eligible patients with relapsing, non‐severe GPA were randomized to receive abatacept 125 mg subcutaneously once a week or placebo, both together with prednisone 30 mg/day (or ...
Carol A. Langford+30 more
wiley +1 more source
Loss of TRIM21 drives UVB‐induced systemic inflammation by regulating DNA‐sensing pathways
Background Patients with systemic lupus erythematosus (SLE) experience photosensitivity, with exposure to ultraviolet light B (UVB) driving lupus flares and triggering symptoms like joint pain, fatigue, and cutaneous lesions. Although the mechanism(s) linking UVB exposure to systemic effects are unclear, type I interferons (IFNs) are known to play a ...
Gantsetseg Tumurkhuu+17 more
wiley +1 more source
Autoantibodies in ulcerative colitis. [PDF]
A. R. McGiven, T. K. Ghose, R. C. Nairn
openalex +1 more source
Objectives Rheumatoid arthritis (RA) is usually preceded and likely mediated by autoantibodies to citrullinated proteins (ACPAs) that recognize citrulline residues on multiple proteins. Conversion of arginine into citrulline is performed by enzymes called peptidyl arginine deiminases (PADs).
Philippe P. Pagni+10 more
wiley +1 more source
Serum Autoantibodies in Myasthenia Gravis and Thymoma: Selective Affinity for I-Bands of Striated Muscle As a Guide to Identification of Antigen(s) [PDF]
Arthur J. L. Strauss, Pierson G. Kemp
openalex +1 more source
Objectives The effect of the shared epitope (SE), and valine at position 11 (Val11) of HLA‐DRB1, on the activation of CD4+ T cells, is expected to be diminished by abatacept, a co‐stimulation blocker. However, published evidence on the value of genetic stratification for abatacept treatment is conflicting.
Chuan Fu Yap+14 more
wiley +1 more source
Objective To assess risks of adverse pregnancy outcomes (APO) in a contemporary cohort of women with systemic sclerosis (SSc) in relation to the timing of SSc diagnosis and by parity. Methods From the nationwide Swedish Medical Birth Register, we assembled pregnancies with births in women with SSc and in comparator women from the general population ...
Weng Ian Che+5 more
wiley +1 more source
THE PRODUCTION OF ERYTHROCYTE AUTOANTIBODIES IN CHIMPANZEES [PDF]
Chester M. Zmijewski
openalex +1 more source