Results 131 to 140 of about 237,743 (361)

Distribution of Certain Autoantibodies in Monozygotic and Dizygotic Twins [PDF]

open access: bronze, 1966
W. Watson Buchanan   +6 more
openalex   +1 more source

A randomized, double‐blind, placebo‐controlled trial of abatacept for the treatment of relapsing, non‐severe, granulomatosis with polyangiitis

open access: yesArthritis &Rheumatology, Accepted Article.
Objective To compare the efficacy of abatacept to placebo for the treatment of relapsing, non‐severe granulomatosis with polyangiitis (GPA). Methods In this multicenter trial, eligible patients with relapsing, non‐severe GPA were randomized to receive abatacept 125 mg subcutaneously once a week or placebo, both together with prednisone 30 mg/day (or ...
Carol A. Langford   +30 more
wiley   +1 more source

CARDIAC AUTOANTIBODIES [PDF]

open access: bronze, 1968
Seymour P. Halbert   +2 more
openalex   +1 more source

Loss of TRIM21 drives UVB‐induced systemic inflammation by regulating DNA‐sensing pathways

open access: yesArthritis &Rheumatology, Accepted Article.
Background Patients with systemic lupus erythematosus (SLE) experience photosensitivity, with exposure to ultraviolet light B (UVB) driving lupus flares and triggering symptoms like joint pain, fatigue, and cutaneous lesions. Although the mechanism(s) linking UVB exposure to systemic effects are unclear, type I interferons (IFNs) are known to play a ...
Gantsetseg Tumurkhuu   +17 more
wiley   +1 more source

Autoantibodies in ulcerative colitis. [PDF]

open access: bronze, 1967
A. R. McGiven, T. K. Ghose, R. C. Nairn
openalex   +1 more source

A tolerogenic plasmid inhibits autoantibody production triggered by immunization with human peptidyl arginine deiminase 4.

open access: yesArthritis &Rheumatology, Accepted Article.
Objectives Rheumatoid arthritis (RA) is usually preceded and likely mediated by autoantibodies to citrullinated proteins (ACPAs) that recognize citrulline residues on multiple proteins. Conversion of arginine into citrulline is performed by enzymes called peptidyl arginine deiminases (PADs).
Philippe P. Pagni   +10 more
wiley   +1 more source

Comparative Effectiveness of Abatacept versus Adalimumab in Shared Epitope positive and negative Rheumatoid Arthritis patients

open access: yesArthritis &Rheumatology, Accepted Article.
Objectives The effect of the shared epitope (SE), and valine at position 11 (Val11) of HLA‐DRB1, on the activation of CD4+ T cells, is expected to be diminished by abatacept, a co‐stimulation blocker. However, published evidence on the value of genetic stratification for abatacept treatment is conflicting.
Chuan Fu Yap   +14 more
wiley   +1 more source

Pregnancy outcomes in women with systemic sclerosis before and/or after diagnosis, and by parity ‐ A Swedish population‐based cohort study

open access: yesArthritis &Rheumatology, Accepted Article.
Objective To assess risks of adverse pregnancy outcomes (APO) in a contemporary cohort of women with systemic sclerosis (SSc) in relation to the timing of SSc diagnosis and by parity. Methods From the nationwide Swedish Medical Birth Register, we assembled pregnancies with births in women with SSc and in comparator women from the general population ...
Weng Ian Che   +5 more
wiley   +1 more source

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