Results 181 to 190 of about 251,978 (341)

Distinct effects of complement C4A and C4B copy number in Systemic Sclerosis serological and clinical subtypes

Arthritis &Rheumatology, Accepted Article.
Objective Complement component 4 (C4), encoded by C4A and C4B within the major histocompatibility complex (MHC) on chromosome 6, regulates the immune response and clears immune complexes. Variable copy number (CN) of C4 genes and retroviral HERV‐K element influence its function.
Javier Martínez‐López, Carlos Rangel‐Peláez, Inmaculada Rodriguez‐Martin, Alfredo Guillen‐Del‐Castillo, Carmen P Simeón‐Aznar, José L Callejas, International SSc Group; PRECISESADs Clinical Consortium, Oliver Distler, Susanna M Proudman, Mandana Nikpour, Australian Scleroderma Interest Group (ASIG), Nicolas Hunzelmann, Gianluca Moroncini, Jeska K de Vries‐Bouwstra, Ariane L Herrick, Yannick Allanore, Marta E. Alarcon‐Riquelme, Lorenzo Beretta, Shervin Assassi, Christopher P Denton, Maureen D Mayes, Javier Martin, Marialbert Acosta‐Herrera, Martin Kerick   +23 more
wiley   +1 more source

Association of Individual or Family History of Autoimmune Disease With Future Development of Type 1 Diabetes. [PDF]

Diabetes Metab Res Rev
Thomas N, Vaidya B, Leslie RD, Agardh D, Oram R, Dabelea D, Singh A, Chantzichristos D, Rewers M.   +8 more
europepmc   +1 more source

Identification of histone deacetylase inhibitor targeting type I interferon and B‐cell abnormalities in systemic lupus erythematosus

Arthritis &Rheumatology, Accepted Article.
Objective Systemic lupus erythematosus (SLE) is characterized by increased type I interferon (IFN‐I) and autoantibody production. This study aimed to identify drugs that can inhibit both IFN‐I and autoantibody production. Methods We identified an inhibitor of IFN‐I production from a chemical library.
Takehiro Hirayama, Hachiro Konaka, Yasuhiro Kato, Takayuki Shibahara, Chisato Nishizawa, Kohei Tsujimoto, JeongHoon Park, Eri Itotagawa, Tatsunori Jo, Masayuki Nishide, Sumiyuki Nishida, Yoshihito Shima, Masashi Narazaki, Wataru Aoki, Ken J Ishii, Hyota Takamatsu, Atsushi Kumanogoh   +16 more
wiley   +1 more source

Clinical Characteristics in Swedish Children With and Without Autoantibodies at the Time of Type 1 Diabetes Diagnosis. [PDF]

Diabetes Care
Hedlund E, Maziarz M, Lindahl T, Elding-Larsen H, Forsander G, Persson M, Pundziute-Lyckå A, Åkesson K, Ludvigsson J, Carlsson A.   +9 more
europepmc   +1 more source

Lifelong evolution of autoreactive plasma cell numbers, affinity and anatomical location in arthritic K/BxN mice

Arthritis &Rheumatology, Accepted Article.
Objective The spontaneous K/BxN mouse model of rheumatoid arthritis has been used extensively to study chronic inflammation, contribution of immune cells, and the primordial role of autoreactive antibodies in disease initiation and severity. Only the ubiquitous enzyme glucose‐6‐phosphate isomerase (GPI) is the target of IgG autoantibodies secreted by ...
Thibault Vanhoucke, Carlos Castrillon, Odile Richard‐Le Goff, Angga Perima, Matteo Broketa, Andrew D. Griffiths, Patrick England, François Huetz, Pierre Bruhns   +8 more
wiley   +1 more source

Structure and dynamics of the autoantigen GAD65 in complex with the human autoimmune polyendocrine syndrome type 2-associated autoantibody b96.11 [PDF]

Susanne H. D. Ständer, Cyril F. Reboul, S Lee, Daniel E. Williams, Peter G. Chandler, Maurício G. S. Costa, David E. Hoke, John D. T. Jimma, James Fodor, Gustavo Fenalti, Stuart I. Mannering, Benjamin T. Porebski, Peter Schofield, Daniel Christ, Malcolm Buckle, Sheena McGowan, Dominika Elmlund, Kasper D. Rand, Ashley M. Buckle   +18 more
openalex   +1 more source

IgG human monoclonal anti-DNA autoantibodies from patients with systemic lupus erythematosus [PDF]

, 1991
Thomas Winkler, Sandro Jahn, Joachim R. Kalden   +2 more
openalex   +1 more source

Exposure to occupational inhalants and the risk of developing rheumatoid arthritis: A systematic review and meta‐analysis

Arthritis &Rheumatology, Accepted Article.
Objective: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint pain, swelling, and stiffness. While smoking is a well‐established risk factor for RA, the role of occupational inhalants in RA development is less well recognized.
Qianwen Liu, Xin Song, Emily Mauro, Yuan Jiang, Klementy Shchetynsky, PLars Klareskog, Lars Alfredsson, Xia Jiang   +7 more
wiley   +1 more source

Large-scale seroepidemiology uncovers nephro-urological pathologies in people with tau autoimmunity. [PDF]

PLoS Biol
Magalhães AD, Emmenegger M, De Cecco E, Carta M, Frontzek K, Chincisan A, Guo J, Hornemann S, Aguzzi A.   +8 more
europepmc   +1 more source

DKA in a toddler negative to type 1 diabetes autoantibodies: unusual presentation of Kearn–Sayre syndrome [PDF]

Annalisa Deodati, Novella Rapini, Diego Martinelli, Mafalda Mucciolo, Rosalba Carozzo, Riccardo Schiaffini, Stefano Cianfarani, Fabrizio Barbetti   +7 more
openalex   +1 more source