Results 81 to 90 of about 237,693 (312)

Post‐Translational Modified Neoantigens in Autoimmune Diseases: Challenges of Immune Tolerance

Advanced Science, EarlyView.
Autoimmune diseases have a high incidence and disability rate. The pathogenesis of autoimmune diseases involves the interaction among genetic factors, environmental factors, and immune disorders. The post‐translational modified neoantigens are the key nodal of these three factors. And these post‐translational modified neoantigens, after being presented
Yue Zhai, Kefei Wu, Qi Lin, Zhenzhen Cao, Yankun Jia, Ping Zhu   +5 more
wiley   +1 more source

Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children.

Journal of the American Medical Association (JAMA), 2013
IMPORTANCE Type 1 diabetes usually has a preclinical phase identified by circulating islet autoantibodies, but the rate of progression to diabetes after seroconversion to islet autoantibodies is uncertain. OBJECTIVE To determine the rate of progression
A. Ziegler, M. Rewers, O. Simell, T. Simell, J. Lempainen, A. Steck, C. Winkler, J. Ilonen, R. Veijola, M. Knip, E. Bonifacio, G. Eisenbarth   +11 more
semanticscholar   +1 more source

Anti‐Inflammatory Mechanisms of Selenium Nanosheets in Ulcerative Colitis: Protein Corona, GP130 Interaction, and Transcriptomic Profile

Advanced Science, EarlyView.
SeNSs provide a biocompatible, anti‐inflammatory UC therapy. SeNSs form protein coronas enriched with AKT/PI3K/NF‐κB pathway proteins, suppress GP130 via hydrophobic interactions, and inhibit pro‐inflammatory cytokines. In DSS‐induced UC mice, SeNSs reduce inflammation, tissue damage, and disease activity by modulating cytokine, chemokine, and ...
Dingyi Shen, Li Gong, Wei Yang, Jiaqi Luo, Zhen Jin, Youzhi Tang   +5 more
wiley   +1 more source

Autoantibodies in the Pathogenesis, Diagnosis, and Prognosis of Juvenile Idiopathic Arthritis

Frontiers in Immunology, 2019
Autoantibody production occurs in juvenile idiopathic arthritis (JIA) and numerous other autoimmune diseases. In some conditions, the autoantibodies are clearly pathogenic, whereas in others the roles are less defined.
Shawn A. Mahmud, B. Binstadt
semanticscholar   +1 more source

Activation of Kir4.1 Channels by 2‐D08 Promotes Myelin Repair in Multiple Sclerosis

Advanced Science, EarlyView.
Multiple sclerosis causes myelin loss and neurological dysfunction. This study shows that 2‐D08, a small molecule targeting Kir4.1 channels, promotes OPCs differentiation via FYN tyrosine kinase phosphorylation and the FYN/MYRF pathway. It significantly improves myelin repair and motor deficits in EAE mice and marmosets, highlighting its potential as a
Mingdong Liu, Shengyu Jin, Xin Fu, Chong Xie, Yi Chen, Liangtang Chang, Yongheng Fan, Donghua He, Xiaoqi Hong, Xi Shen, Xiaoli Zheng, Qiyue Wang, Dao Shi, Fangyuan Li, Daishun Ling, Yangtai Guan, Neng Gong, Xiaoping Tong   +17 more
wiley   +1 more source

Extrahepatic Manifestations and Autoantibodies in Patients with Hepatitis C Virus Infection

Clinical and Developmental Immunology, 2012
Patients with chronic hepatitis C virus (HCV) infection frequently have many extrahepatic manifestations, as persistent HCV infection often triggers lymphoproliferative disorders and metabolic abnormalities.
Takashi Himoto, Tsutomu Masaki
doaj   +1 more source

The Clinical Value of Autoantibodies in Rheumatoid Arthritis

Frontiers in Medicine, 2018
Rheumatoid arthritis (RA) is a highly heterogeneous syndrome in terms of clinical presentation, progression, and response to therapy. In such a complicated context, the identification of disease-related biomarkers would be undoubtedly helpful in ...
S. Bugatti, A. Manzo, C. Montecucco, R. Caporali   +3 more
semanticscholar   +1 more source

Autoimmune Hepatobiliary Disease and Cryoglobulins in Peripheral Blood

American Journal of Hematology, EarlyView.
Cryoglobulins in Autoimmune Hepatobiliary Disease.
Anna Shestakova, Anton V. Rets, Madhu Menon   +2 more
wiley   +1 more source

Anti‐ADAMTS13 Antibodies Trajectory is Associated With ADAMTS13 Recovery in Immune‐Mediated TTP

American Journal of Hematology, EarlyView.
Anti‐ADAMTS13 IgG antibodies titer trajectory from baseline to day 7–14 post‐TPE as a reliable approach to identify iTTP patients at risk of late response to the triplet therapy regimen. ABSTRACT Current triplet regimens associating therapeutic plasma exchange (TPE), immunosuppression with corticosteroids and rituximab, and caplacizumab have ...
Marie Robert, Arthur Mageau, Ygal Benhamou, François Provôt, Jehane Fadlallah, Lionel Galicier, Elie Azoulay, Hafid Ait‐Oufella, Tomas Urbina, Pascale Poullin, Alain Wynckel, Coralie Poulain, Nihal Martis, Pierre Perez, Virginie Rieu, Yahsou Delmas, Jean‐Michel Halimi, Christelle Barbet, Amélie Seguin, Valérie Chatelet, Jean‐François Augusto, Mathieu Legendre, Olivier Moranne, Carole Philipponnet, Bérengère Cador, Raïda Bouzid, Bérangère S. Joly, Agnès Veyradier, Paul Coppo, on behalf of the French Reference Center for Thrombotic Microangiopathies   +29 more
wiley   +1 more source

Cold Agglutinin Syndrome Secondary to Mycoplasma pneumoniae Infection in Adults: Results From a Large French Observational Study (MyCOLD Study)

American Journal of Hematology, EarlyView.
Summary of the main results of the MYCOLD studies. ABSTRACT Mycoplasma pneumoniae (MP), primarily a respiratory pathogen, can cause extra‐pulmonary manifestations including cold agglutinin syndrome (CAS). We conducted a national, multicenter, observational, ambispective study to describe the characteristics, risk factors, and outcomes of MP‐associated ...
Kevin Chevalier, Matthieu Holub, Romain Palich, Karine Blanckaert, Laurent Gilardin, Louis Terriou, Bérangère Arnould, Solal Bellaiche, Samuel Deshayes, Julie Mérindol, Simon Rolland, Simon Valentin, Rishma Amarsy, Sylvain Audia, Virginie Baltes, Amaury Barret, Pierre‐Louis Cariou, Jessy Cattelan, Hortense Chassepot, Dorothée Chopin, Mélissa Clément, Marine Coeffier, Thibault Comont, Soline De Monteynard, Charles Declerck, Pauline Durand, Mikael Ebbo, Gaël Galli, Amélie Godot, Sarra Hamrouni, Charlotte Kaeuffer, Jean‐Emmanuel Kahn, Ludovic Lassel, Sophie Leautez, Anne‐Lise Lecapitaine, Gwenael Le Moal, David Luque Paz, Martin Martinot, Natacha Mrozek, Valentine Pagis, Thomas Perpoint, Valéry Salle, Jean‐François Viallard, Clément Viguier, Matthieu Mahevas, Bertrand Godeau, Etienne Crickx, Marc Michel   +47 more
wiley   +1 more source