Results 131 to 140 of about 219,094 (347)
Novel prokaryotic expression of thioredoxin-fused insulinoma associated protein tyrosine phosphatase 2 (IA-2), its characterization and immunodiagnostic application [PDF]
, 2016 Background The insulinoma associated protein tyrosine phosphatase 2 (IA-2) is one of the immunodominant autoantigens involved in the autoimmune attack to the beta-cell in Type 1 Diabetes Mellitus.
A Trabucchi +95 more
core +5 more sources
Autoantibody-Targeted Treatments for Acute Exacerbations of Idiopathic Pulmonary Fibrosis
PLoS ONE, 2015 Background Severe acute exacerbations (AE) of idiopathic pulmonary fibrosis (IPF) are medically untreatable and often fatal within days. Recent evidence suggests autoantibodies may be involved in IPF progression.
M. Donahoe +8 more
semanticscholar +1 more source
Frontiers in Immunology, 2019 One of the most important functions of the skin besides regulating internal body temperature includes formation of the barrier between the organism and the external environment, hence protecting against pathogen invasion, chemical and physical assaults ...
Natalie E. Stevens +2 more
doaj +1 more source
Flexible Bayesian additive joint models with an application to type 1 diabetes research [PDF]
arXiv, 2016 The joint modeling of longitudinal and time-to-event data is an important tool of growing popularity to gain insights into the association between a biomarker and an event process. We develop a general framework of flexible additive joint models that allows the specification of a variety of effects, such as smooth nonlinear, time-varying and random ...
arxiv
Mechanisms of Autoantibody Production in Systemic Lupus Erythematosus
Frontiers in Immunology, 2015 Autoantibodies against a panoply of self-antigens are seen in systemic lupus erythematosus, but only a few (anti-Sm/RNP, anti-Ro/La, anti-dsDNA) are common.
Shuhong Han +4 more
semanticscholar +1 more source
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Hereditary multiple osteochondromas (HMO) is an autosomal dominant disorder caused by heterozygous deleterious variants in the EXT1 or EXT2 genes. While the clinical core phenotype is well established and mainly consists of bone deformities, limb length discrepancies, multiple benign bone neoplasms, and increased risk of chondrosarcoma, the ...
Francesco Comisi +7 more
wiley +1 more source
Journal of Clinical Apheresis, Volume 37, Issue 6, Page 597-599, December 2022., 2022 Abstract Pediatric autoimmune neuropsychiatric disorders associated with streptococcal (PANDAS) infections and pediatric acute‐onset neuropsychiatric syndrome (PANS) are typically diagnosed in childhood. Therapeutic plasma exchange (TPE) has been recommended to remove relevant antibodies and treat symptomatic presentations in children and adolescents ...
Kristina Prus +2 more
wiley +1 more source
Comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies'
eLife, 2019 The AIRE gene plays a key role in the development of central immune tolerance by promoting thymic presentation of tissue-specific molecules. Patients with AIRE-deficiency develop multiple autoimmune manifestations and display autoantibodies against the ...
Nils Landegren +12 more
doaj +1 more source
Protein Microarrays with Carbon Nanotubes as Multi-Color Raman Labels [PDF]
arXiv, 2008 Detection of biomolecules is important in proteomics and clinical diagnosis and treatment of diseases. Here, we apply functionalized, macromolecular, single walled carbon nanotubes SWNTs as multi-color Raman labels to protein arrays for highly sensitive, multiplexed protein detection.
arxiv
Nuclear matrix protein 2 antibody-positive adult dermatomyositis: a case report and review of the literature [PDF]
, 2020 Dermatomyositis is a clinically heterogenous inflammatory myopathy with unique cutaneous features. Myositis-specific antibodies can aid in diagnosis and anticipation of patient prognosis.
Cartron, Alexander M +3 more
core