Results 201 to 210 of about 44,434 (254)

What Makes an Autoantigen an Autoantigen?

Annals of the New York Academy of Sciences, 2005
Abstract: Multiple classes of proteins are modified to tailor them for specific physiological roles. The nature of these posttranslational modifications of proteins, as well as the relationships between them including those of the immune system proteins themselves, and immune system responses are reviewed.
Chih-Te, Wu, M Eric, Gershwin, Paul A, Davis   +2 more
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Human Autoantigen Atlas: Searching for the Hallmarks of Autoantigens

Journal of Proteome Research, 2023
Understanding autoimmunity to endogenous proteins is crucial in diagnosing and treating autoimmune diseases. In this work, we developed a user-friendly AAgAtlas portal (http://biokb.ncpsb.org.cn/aagatlas_portal/index.php#), which can be used to search for 8045 non-redundant autoantigens (AAgs) and 47 post-translationally modified AAgs against 1073 ...
Dan Wang, Dong Yang, Liuhui Yang, Lihong Diao, Yuqi Zhang, Yang Li, Hongye Wang, Jing Ren, Linlin Cheng, Qiaoyun Tan, Ran Zhang, Xiaohong Han, Xiaohan Zhang, Bingwei Wang, Dong Li, Meng Chen, Henning Hermjakob, Yongzhe Li, Joshua LaBaer, Zhou Zhou, Xiaobo Yu   +20 more
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Features of autoantigens

Molecular Biology Reports, 1996
The major cellular antigens recognized by autoantibodies in SLE and other systemic autoimmune diseases have been identified and characterized over the past 25 years. The pioneering studies of Eng Tan demonstrate the importance of autoantibodies as diagnostic markers.
W H, Reeves, M, Satoh
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Humanization of autoantigen

Nature Medicine, 2007
Transmissibility of characteristic lesions to experimental animals may help us understand the pathomechanism of human autoimmune disease. Here we show that human autoimmune disease can be reproduced using genetically engineered model mice. Bullous pemphigoid (BP) is the most common serious autoimmune blistering skin disease, with a considerable body of
Nishie, Wataru, Sawamura, Daisuke, Goto, Maki, Ito, Kei, Shibaki, Akihiko, McMillan, James R., Sakai, Kaori, Nakamura, Hideki, Olasz, Edit, Yancey, Kim B., Akiyama, Masashi, Shimizu, Hiroshi   +11 more
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Autoantigens in thyroid diseases

Springer Seminars in Immunopathology, 1993
The autoantigens involved in autoimmune thyroid disease have now been extensively characterised, and the autoantibodies they evoke provide important aids to diagnosis, leading to early treatment of thyroid autoimmunity. The next stage in the puzzle is to determine towards which epitopes on the autoantigens the immune response is directed.
K, Dawe, P, Hutchings, B, Champion, A, Cooke, I, Roitt   +4 more
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Ubiquitination of Ro52 autoantigen

Biochemical and Biophysical Research Communications, 2002
Anti-Ro/SSA antibodies are antinuclear antibodies most commonly found in patients with Sjögren's syndrome, a chronic autoimmune disease characterized by dryness of the eyes and mouth. The autoantibodies recognize a RING-finger protein, Ro52/SSA (52 kDa), whose function is still unknown. In this study, the ubiquitination of Ro52 was investigated.
Taeko, Fukuda-Kamitani, Tetsu, Kamitani
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Thermostable Brain-Specific Autoantigen

The Journal of Immunology, 1967
Summary Evidence was presented for autoantibody formation against a thermostable ethanol-insoluble antigen (BE antigen) characteristic for brain. Rabbit antisera to brain BE of human and porcine origin combined with rabbit brain BE. Antisera of rabbits immunized with rabbit brain BE and of pigs immunized with porcine brain BE contained ...
F, Milgrom, Z M, Tuggac, W, Campbell, E, Witebsky   +3 more
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Golgi Autoantibodies and Autoantigens

Journal of Autoimmunity, 1994
Autoantibodies directed against cellular constituents rarely react with antigens localized in the Golgi apparatus and little information is available regarding these particular antibodies. Although thousands of samples have been examined for autoantibodies in our laboratory on a routine basis, only three human sera with anti-Golgi antibodies could be ...
G, Renier, M C, Rousselet, F, Carrere, A, Croue, C, André, F, Oksman, A, Chevailler, D, Hurez   +7 more
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Sperm autoantigens and fertilization. III. Ultrastructural localization of guinea pig autoantigens

The Anatomical Record, 1982
AbstractGuinea pig sperm autoantigens have been localized by direct and indirect immunoferritin techniques in (1) plasma membrane over the entire sperm head, (2) acrosomal contents, (3) fibrous sheath and outer dense fibers of the tail filament, and (4) the inner acrosomal membrane of 50% of acrosome reacted spermatozoa.
K S, Tung, H, Yanagimachi, R, Yanagimachi   +2 more
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Hepatic and biliary Autoantigens

Immunological Investigations, 1989
Chronic active hepatitis (CAH) and primary biliary cirrhosis (PBC) are two enigmatic liver diseases in which autoimmunity is implicated. Provisional criteria to separate the autoimmune type of CAH (A-CAH) from others are specified. Western immunoblotting using disease sera and antibody screening of a rat liver gene expression library were used to ...
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