Results 41 to 50 of about 212,828 (333)

Composite bulkhead fabrication development [PDF]

open access: yes, 1966
Composite bulkhead is produced by a fabrication concept utilizing vacuum and/or autoclave pressure to hold preformed welded sandwich elements in place during bonding and ...
Orr, J.
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Requirement verification in simulation-based automation testing

open access: yes, 2016
The emergence of the Industrial Internet results in an increasing number of complicated temporal interdependencies between automation systems and the processes to be controlled.
Karhela, Tommi   +4 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Residual strain monitoring during composite manufacturing [PDF]

open access: yes, 2012
This work explores a new possibility in accurate measurement of multi-axial residual strains during the production of composite structures. It investigates the usability of the polarization dependent loss (PDL) of an optical fibre Bragg grating as a ...
Caucheteur, Christophe   +5 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Bioreactor design from an Obsolete Autoclave

open access: yesTecnología en Marcha, 2014
One of the known methodologies for solid waste treatment is bacterial decomposition in a controlled environment, under special and anaerobic conditions, inside an equipment called bioreactor.
Teresa Salazar-Rojas   +1 more
doaj   +1 more source

Comparison of Autoclave and Out-of-Autoclave Composites [PDF]

open access: yes, 2010
The National Aeronautics and Space Administration (NASA) Exploration Systems Mission Directorate initiated an Advanced Composite Technology Project through the Exploration Technology Development Program in order to support the polymer composite needs for
Fikes, John   +12 more
core   +1 more source

Biosafety and Biohazards: Understanding Biosafety Levels and Meeting Safety Requirements of a Biobank. [PDF]

open access: yes, 2019
When it comes to biobanking and working with different types of laboratory specimens, it is important to understand potential biohazards to ensure safety of the operator and laboratory personnel.
Gosa, Laura   +2 more
core   +2 more sources

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

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