Results 171 to 180 of about 130,699 (298)

Targeted senotherapy improves electrographic and behavioral outcomes in a mouse model of temporal lobe epilepsy

Epilepsia, EarlyView.
Abstract Objective Current pharmacotherapy for temporal lobe epilepsy (TLE) is limited to symptomatic treatment and leaves approximately one third of patients with inadequate seizure control. Discovering disease‐modifying targets is an unmet clinical need. We have previously identified senescent cells (SCs) as one such target. Many drugs that eliminate
David J. McFall, Abbas I. Hussain, Michelle Cho, Patrick A. Forcelli   +3 more
wiley   +1 more source

Autofluorescence enhances intraoperative detection of parathyroid glands: a single-center comparative study. [PDF]

Front Endocrinol (Lausanne)
Dubuis JB, Meyer J, Mavromati M, Leboulleux S, Triponez F, Demarchi MS.   +5 more
europepmc   +1 more source

Strategic construction of fluorinated surroundings in NIR‐II‐emissive organic semiconducting agents for amplifying cancer phototheranostics

FlexMat, EarlyView.
The development of conventional phototheranostic nanomedicines suffers from an intrinsic trade‐off between NIR‐II fluorescence emission and phototherapeutic effects, leading to poor overall efficacy. Herein, we propose an innovative fluorination strategy by constructing fluorinated surroundings in NIR‐II‐emissive organic semiconducting agents to ...
Xiaoming Hu, Achen Qin, Caijun Zhu, Jinshuo Mi, Zejing Chen, Jiaying Shao, Zhen Li, Zhen Yang   +7 more
wiley   +1 more source

Research progress on the use of the optical coherence tomography system for the diagnosis and treatment of central nervous system tumors

Ibrain, Volume 11, Issue 1, Page 3-18, Spring 2025.
With the advantages of high‐resolution imaging, efficient image acquisition, intraoperative real‐time detection, and radiation‐free and noninvasive characteristics, optical coherence tomography (OCT) provides accurate diagnosis and effective intraoperative guidance for the minimally invasive diagnosis and treatment of central nervous system (CNS ...
Jiuhong Li, Ziba Ayi, Gonggong Lu, Haibo Rao, Feilong Yang, Jing Li, Jiachen Sun, Junlin Lu, Xulin Hu, Si Zhang, Xuhui Hui   +10 more
wiley   +1 more source

Intraoperative near-infrared autofluorescence in parathyroidectomy: associations with gland morphology, body mass index, and histopathology. [PDF]

Gland Surg
Chen W, Wei Z, Zhang Z, Hu J, Huang Y, Luo T, Chen L, Pan X, Chen H, Ge J, Lei S.   +10 more
europepmc   +1 more source

Immune Checkpoint Inhibitors Induce Intestinal Epithelial Injury and a Senescence‐Like Phenotype

iNew Medicine, EarlyView.
ICI treatment promotes the infiltration of activated immune cells into the intestinal mucosa. This inflammatory microenvironment is associated with significant epithelial injury, characterized by the disruption of the epithelial barrier, the depletion of specialized secretory cell lineages, and the induction of a premature senescence phenotype ...
Juan Wang, Shuang Wu, Shuangbiao Wei, Weizhen Xiang, Jianshang Huang, Lei Xiong, Hua Wang, Li Zuo   +7 more
wiley   +1 more source

Detection and quantification of rumen methanogens using F₄₂₀ autofluorescence profiling with spectral flow cytometry. [PDF]

Appl Environ Microbiol
Khanum S, Roberts JM, Della Rosa MM, Sage R, Reid PM, Soni P, Bagley S, Muetzel S, Janssen PH, Wedlock DN.   +9 more
europepmc   +1 more source

Monitoring behaviorally induced biochemical changes using fluorescence lifetime photometry [PDF]

, 2019
Chen, Yao, Lee, Suk Joon, Lodder, Bart, Sabatini, Bernardo L   +3 more
core   +1 more source

Development of Selective Plane Illumination Surface Enhanced Raman Scattering Spectral Microscopy for Improved Cellular Imaging

Journal of Raman Spectroscopy, EarlyView.
Selective plane illumination (SPI) is combined with SERS spectral imaging to reduce background, improve image contrast, and enable improved spectroscopy from molecules on the surface of nanoparticles. This approach provides improved imaging and spectroscopy from nanoparticles in complex environments, such as biological cells.
Abigail E. Smith, Zachary D. Schultz
wiley   +1 more source

Optical differentiation of lung cancer subtypes using laser absorbance, auto-fluorescence emission and Raman spectroscopy: a case series. [PDF]

J Thorac Dis
Cui YJ, Lee W, Kim BK, Cho H.
europepmc   +1 more source