The PYRIN domain is required for TLR4-mediated inflammation by PYHIN family members
iScienceSummary: Innate immunity relies on pattern recognition receptors (PRRs) to detect threats, including pathogens and damage-associated molecular patterns (DAMPs) from damaged cells. IFI16 behaves as a DAMP and activates Toll-like receptor 4 (TLR4)-mediated
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