Results 231 to 240 of about 865,910 (294)

Risk of cardiovascular and autoimmune disease in people with multiple sclerosis on long-term interferon-β therapy. [PDF]

Brain Commun
Rioux B, Zhu F, Ng HS, Zhao Y, Caparrotta TM, Whiteley WN, Hunt DPJ, Tremlett H.   +7 more
europepmc   +1 more source

cGAS Inhibits ALDH2 to Suppress Lipid Droplet Function and Regulate MASLD Progression

Advanced Science, EarlyView.
cGAS is a cytosolic DNA sensor known for innate immune defense. cGAS binds and suppresses ALDH2 are showed, limiting acetyl‐CoA production. cGAS loss activates ALDH2, promoting histone acetylation, lipogenesis, and lipid droplets accumulation. cGas‐/‐ mice on a high‐fat diet show signs of worsened MASLD.
Ying Wang, Yu Deng, Jianfeng Chen, Quentin Hahn, David S. Umbaugh, Zhigang Zhang, Yanqiong Zhang, Sarah E. Rowe, Lupeng Li, Laura E. Herring, Brian P. Conlon, Edward A. Miao, Blossom Damania, Anna Mae Diehl, Pengda Liu   +14 more
wiley   +1 more source

Case Report: Treating one autoimmune disease induces another: the paradox of TNF-alpha inhibitor therapies. [PDF]

Front Immunol
Gehrke M, Thurau S, Wildner G.
europepmc   +1 more source

B‐EPIC: A Transformer‐Based Language Model for Decoding B Cell Immunodominance Patterns

Advanced Science, EarlyView.
B‐Epic: Achieving high‐accuracy B cell epitope prediction through Transformer architecture. Comprehensive validation demonstrates B‐Epic's robust performance across diverse datasets. B‐Epic facilitates vaccine development for H. pylori and EBV, addressing critical public health challenges.
Jun‐Ze Liang, Youtao Wang, Cong Sun, Tao Liu, Zengfeng Wu, Lipeng Chen, Lina Chen, Penglin Li, Zhengkang Li, Cangui Zhang, Bingyun Lu, Ye Chen, Bing Gu, Qian Zhong, Xin Wei Wang, Mu‐Sheng Zeng, Jinping Liu   +16 more
wiley   +1 more source

Autoimmune disease: genetic susceptibility, environmental triggers, and immune dysregulation. Where can we develop therapies? [PDF]

Front Immunol
Kumar M, Yip L, Wang F, Marty SE, Fathman CG.   +4 more
europepmc   +1 more source

LB0007 CC312, A NOVEL ENGINEERED CD19/CD3/CD28 TRI-SPECIFIC ANTIBODY，LEADS TO RAPID AND DEEP B-CELL DEPLETION AND HAS BROAD POTENTIAL FOR DEVELOPMENT IN AUTOIMMUNE DISEASES

Jingjing Qi, Yan Huang, Rong Zhang, Juan Zhen, Xian Zhang, Y. Wei   +5 more
openalex   +1 more source

TREM2 Drives Neutrophil Extracellular Traps‐Induced Dendritic Cell Maturation and Contributes to Lupus Progression

Advanced Science, EarlyView.
TREM2 recognizes NETs‐derived MPO to promote DC maturation and antigen presentation, thereby exacerbating the autoimmune response in SLE. Mechanistically, TREM2 activation triggers the DAP12/SYK/ERK cascade and enhances NETs internalization by DCs, which in turn activates the cGAS/STING signaling pathway.
Jingxian Shu, Jiabi Liang, Linda Zeng, Shuping Zhong, Xueling Fang, Yating Xu, Yongjian Wu, Xi Huang   +7 more
wiley   +1 more source

Changes in the <i>Subdoligranulum</i> genus in patients with autoimmune disease: a systematic review and meta-analysis. [PDF]

Front Immunol
Shen L, Zhao Y, Liu S, Li S, Li Q, Tung TH, Shen B.   +6 more
europepmc   +1 more source

Polysaccharide Adjuvants as Innate Immune Trainers: Bridging Pattern Recognition Receptor (PRR) Activation and Metabolic Reprogramming for Synthetic Vaccine Design

Advanced Science, EarlyView.
Polysaccharides modulate immune responses by engaging pattern recognition receptors (PRRs) to induce T‐cell activation. In vaccine design, their particle size critically influences lymph node targeting and activation mechanisms. By engineering structural complexity and multivalent PRR engagement, polysaccharides enable precise modulation of immune ...
Jeong Hyun Moon, May Thazin Phoo, Yubin Kim, Jinsung Ahn, April Kim, Jutaek Nam, Soo‐Hong Lee, James J. Moon, Sejin Son   +8 more
wiley   +1 more source

Exosomal non-coding RNAs: gatekeepers of inflammation in autoimmune disease. [PDF]

J Inflamm (Lond)
Saadh MJ, Allela OQB, Al-Hussainy AF, Baldaniya L, Rekha MM, Nathiya D, Kaur P, Aminov Z, Sameer HN, Hameed HG, Athab ZH, Adil M.   +11 more
europepmc   +1 more source