Results 251 to 260 of about 9,923,027 (411)

Significance of Circulating Anti-Thyroid Stimulating Hormone (TSH) Receptor Antibodies in Patients with Autoimmune Thyroid Diseases

, 1989
Takashi Fujihira
openalex   +2 more sources

Eosinophils‐Induced Lumican Secretion by Synovial Fibroblasts Alleviates Cartilage Degradation via the TGF‐β Pathway Mediated by Anxa1 Binding

Advanced Science, EarlyView.
Eosinophils play a crucial role in the progression of temporomandibular joint osteoarthritis (TMJOA). This study demonstrates that eosinophils, induced by OVA/IL‐5, promote Lumican secretion in the synovium, which binds to Annexin A1 in chondrocytes, inhibiting transforming growth factor β2 and Smad2/3 phosphorylation.
Wenqian Chen, Yuwei Zhou, Wenxiu Yuan, Yanjing Ou, Hanyu Lin, Kaixun He, Xueshen Qian, Huachen Chen, Chengchaozi Wang, Jie Lu, Weiping Chen, Dexiong Li, Jiang Chen   +12 more
wiley   +1 more source

Neonatal lupus erythematosus: an acquired autoimmune disease to be taken seriously. [PDF]

Ann Med
Sun W, Fu C, Jin X, Lei C, Zhu X.
europepmc   +1 more source

Development of autoimmune disease in SCID mice populated with long-term "in vitro" proliferating (NZB x NZW)F1 pre-B cells. [PDF]

, 1992
Luc Reininger, T Radaszkiewicz, Marie H. Kosco, Fritz Melchers, A Rolink   +4 more
openalex   +1 more source

Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells

Nature, 2013
Markus Kleinewietfeld, A. Manzel, J. Titze, H. Kvakan, N. Yosef, R. Linker, D. Muller, D. Hafler   +7 more
semanticscholar   +1 more source

Enhancing Specificity, Precision, Accessibility, Flexibility, and Safety to Overcome Traditional CRISPR/Cas Editing Challenges and Shape Future Innovations

Advanced Science, Volume 12, Issue 28, July 24, 2025.
CRISPR/Cas9, while transformative, faces challenges in specificity, precision, delivery, accessibility, flexibility, and safety. This review addresses these limitations by highlighting strategies to reduce off‐target effects, exploring HDR‐based and alternative editing approaches, and evaluating advanced delivery mechanisms.
Muna Alariqi, Mohamed Ramadan, Lu Yu, Fengjiao Hui, Amjad Hussain, Xiaofeng Zhou, Yu Yu, Xianlong Zhang, Shuangxia Jin   +8 more
wiley   +1 more source

The PYRIN domain is required for TLR4-mediated inflammation by PYHIN family members

iScience
Summary: Innate immunity relies on pattern recognition receptors (PRRs) to detect threats, including pathogens and damage-associated molecular patterns (DAMPs) from damaged cells. IFI16 behaves as a DAMP and activates Toll-like receptor 4 (TLR4)-mediated
Andrea Iannucci, Davide Lacarbonara, Valeria Caneparo, Federica Castiglioni, Andrea Butticè, Stefano Raviola, Chiara Porta, Riccardo Miggiano, Ivan Zanoni, Marisa Gariglio, Marco De Andrea   +10 more
doaj  

The Crosstalk Between NETs and the Complement Cascade: An Overview in Nephrological Autoimmune Disease. [PDF]

Int J Mol Sci
Kajana X, Caridi G, Bruschi M, Spinelli S, Lugani F, Ghiggeri GM, La Porta E, Mortari G, Verrina EE, Angeletti A, Bigatti C.   +10 more
europepmc   +1 more source

Maximizing Efficacy of Cancer Nanovaccines and Immune Cells Landscape in Responders and Non‐Responders to Immunotherapy

Advanced Science, EarlyView.
To maximize the efficacy of cancer vaccines, adjuvants, collection, lysis, purification, oxidation, loading sites, and sizes, etc., are investigated. The optimized cancer nanovaccines loading whole tumor antigens can cure all or most tumor‐bearing mice in multiple mouse cancer models.
Xiangxiang Xu, Lu Diao, Jin Wang, Ao Zhu, Xianlan Chen, Yan Zheng, Yuhan Liu, Kang Hu, Jiashan Zhu, Cheng Ding, Chang Li, Yunzhi Pan, Jun Zhao, Mi Liu   +13 more
wiley   +1 more source

Genetic relationships between systemic lupus erythematosus and a positive antinuclear antibody test in the absence of autoimmune disease. [PDF]

Lupus Sci Med
Khan A, Karakoc G, Liu G, Zanussi J, Olsen NJ, Shi M, Cox NJ, Mosley J, Stein CM, Kiryluk K, Wei WQ, Mentch F, Hebbring S, Linneman J, Kawai V.   +14 more
europepmc   +1 more source