Results 251 to 260 of about 885,466 (342)

Adult Stem Cell Therapy for Autoimmune Disease

, 2009
Eun Wha Choi
openalex   +2 more sources

Extracellular Vesicle‐Delivered tRF‐His‐GTG‐1 Reprograms Neutrophil Lipophagy and Triggers Inflammation in COVID‐19

Advanced Science, EarlyView.
This study identifies platelet‐derived extracellular vesicles as key immunometabolic regulators in COVID‐19. The delivery of tRF‐His‐GTG‐1 to neutrophils activates TLR8mTOR signaling, disrupts lipophagy, and amplifies NET‐mediated inflammation. Importantly, targeting this axis restores neutrophil homeostasis, offering a potential therapeutic strategy ...
Tsai‐Ling Liao, Po‐Yu Liu, Yi‐Ming Chen, Kuo‐Tung Tang, Hung‐Jen Liu, Der‐Yuan Chen   +5 more
wiley   +1 more source

New onset autoimmune disease following a SARS-CoV-2 infection: A systematic review protocol. [PDF]

PLoS One
Grima AA, Hiraki LT, Bolotin S, Paterson AD, Brooks JD.   +4 more
europepmc   +1 more source

Coombs Negative Autoimmune Hemolytic Anemia in Crohn’s Disease

, 2014
Yang Wook Kim
openalex   +1 more source

DEL‐1 is an Endogenous Senolytic Protein that Inhibits Senescence‐Associated Bone Loss

Advanced Science, EarlyView.
Senescent bone marrow stromal cells accumulate in the aging bone microenvironment, promoting bone degeneration. DEL‐1, an endogenous secreted protein, acts as a natural senolytic that selectively eliminates these cells. By engaging a β3 integrin/CD73/adenosine/p38 MAPK/BCL‐2 pathway, DEL‐1 counters aging‐related bone loss, revealing promising ...
Jong‐Hyung Lim, Kridtapat Sirisereephap, Hui Wang, Giulia Trimaglio, Kyoung‐Jin Chung, Jonathan Korostoff, Tetsuhiro Kajikawa, Xiaofei Li, Meircurius D.C. Surboyo, Tomoki Maekawa, Triantafyllos Chavakis, George Hajishengallis   +11 more
wiley   +1 more source

Association between autoimmune disease and colorectal cancer: a retrospective case-control study of 120 876 patients. [PDF]

BMJ Open Gastroenterol
Loosen SH, Hansen F, Luedde T, Roderburg C, Kostev K.   +4 more
europepmc   +1 more source

Wedelolactone, a Novel TLR2 Agonist, Promotes Neutrophil Differentiation and Ameliorates Neutropenia: A Multi‐Omics Approach to Unravel the Mechanism

Advanced Science, EarlyView.
Wedelolactone (WED), a natural TLR2 agonist, promotes neutrophil differentiation and enhances bactericidal function, offering a potential therapeutic strategy for neutropenia. Using a multi‐omics approach, this study reveals that WED activates the TLR2/MEK/ERK pathway, upregulating key transcription factors (PU.1, CEBPβ) to drive neutrophil development.
Long Wang, Zhichao Li, Tianci Hu, Qinyao Li, Linwei Zhang, Xinyue Mei, Xiao Qi, Sheng Liu, Weijie Kong, Jiesi Luo, Anguo Wu, Feihong Huang, Sirui Li, Shuang Dai, Chunxiang Zhang, Rong Li, Jianming Wu   +16 more
wiley   +1 more source

Thymic central tolerance takes centre stage in autoimmune disease. [PDF]

Lancet Reg Health West Pac
Mulic-Al Bunni S, Handel AE.
europepmc   +1 more source

A Bite of B Cells: The Potential Role of Bispecific T Cell Engager Therapy (BiTE) in Autoimmune Diseases [PDF]

Jie‐Fu Zheng, Yung‐Heng Lee, Shih‐Wen Kao, James Cheng‐Chung Wei   +3 more
openalex   +1 more source