Results 81 to 90 of about 9,870,953 (338)
Nature Genetics, 2017 Most autoimmune-disease-risk effects identified by genome-wide association studies (GWAS) localize to open chromatin with gene-regulatory activity. GWAS loci are also enriched in expression quantitative trait loci (eQTLs), thus suggesting that most risk ...
S. Chun +7 more
semanticscholar +1 more source
Novel associations for hypothyroidism include known autoimmune risk loci [PDF]
, 2011 Hypothyroidism is the most common thyroid disorder, affecting about 5% of the general population. Here we present the first large genome-wide association study of hypothyroidism, in 2,564 cases and 24,448 controls from the customer base of 23andMe, Inc.,
A Alcina +57 more
core +10 more sources
Can unilateral, progressive or sudden hearing loss be immune-mediated in origin? [PDF]
, 2017 OBJECTIVE: The aim of the present study was to demonstrate that the positivity of nonspecific immunological tests could be found not only in bilateral hearing loss but also in unilateral cases, either sudden or progressive. METHOD: An observational case
Atturo, Francesca +4 more
core +1 more source
Celiac Disease Autoimmunity [PDF]
Archivum Immunologiae et Therapiae Experimentalis, 2018 Celiac disease is an autoimmune condition triggered by the ingestion of gluten, the protein fraction of wheat, barley and rye. It is not simply an intestinal disease; it is multifactorial caused by many different genetic factors acting together with non-genetic causes.
Miguel Ángel López Casado +4 more
openaire +4 more sources
The dual role of short fatty acid chains in the pathogenesis of autoimmune disease models
PLoS ONE, 2017 Autoimmune diseases are influenced by both genetic and environmental factors. The gut environment has attracted much attention as an essential component that modulates immune responses, and therefore immune-mediated disorders, such as autoimmune diseases.
M. Mizuno +4 more
semanticscholar +1 more source
Journal of Translational Medicine, 2022 Background According to the Global Cancer Statistics in 2020, the incidence and mortality of colorectal cancer (CRC) rank third and second among all tumors.
Wei Zhang +11 more
doaj +1 more source
Journal of the American Medical Association (JAMA), 2016 Importance Timing of introduction of allergenic foods to the infant diet may influence the risk of allergic or autoimmune disease, but the evidence for this has not been comprehensively synthesized.
D. Ierodiakonou +14 more
semanticscholar +1 more source
Genetic relationships between A20/TNFAIP3, chronic inflammation and autoimrnune disease [PDF]
, 2011 A20 [also known as TNFAIP3 (tumour necrosis factor a-induced protein 3)] restricts and terminates inflammatory responses through modulation of the ubiquitination status of central components in NF-kappa B (nuclear factor kappa B), IRF3 (interferon ...
Beyaert, Rudi +2 more
core +2 more sources
Frontiers in Immunology, 2022 BackgroundThe human leukocyte antigen (HLA) susceptibility gene is the main genetic risk factor for primary biliary cholangitis (PBC). The prognosis of patients with PBC is linked to gut microbiota dysbiosis.
Chun-Yang Huang +17 more
doaj +1 more source
Apeced in Turkey: a case report and insights on genetic and phenotypic variability [PDF]
, 2018 APECED is a rare monogenic recessive disorder caused by mutations in the AIRE gene. In this manuscript, we report a male Turkish patient with APECED syndrome who presented with chronic mucocutaneous candidiasis associated with other autoimmune ...
Alessandra Fierabraccia +4 more
core +1 more source