Results 121 to 130 of about 9,659,727 (409)

The role of tunable activation thresholds in the dynamics of autoimmunity [PDF]

J. Theor. Biol. 308, 45-55 (2012), 2012
It has been known for some time that human autoimmune diseases can be triggered by viral infections. Several possible mechanisms of interactions between a virus and immune system have been analysed, with a prevailing opinion being that the onset of autoimmunity can in many cases be attributed to "molecular mimicry", where linear peptide epitopes ...
arxiv  

Hashimoto's thyroiditis and autoimmune gastritis [PDF]

, 2017
The term "thyrogastric syndrome" defines the association between autoimmune thyroid disease and chronic autoimmune gastritis (CAG), and it was first described in the early 1960s.
Brusca, Nunzia, Capriello, Silvia, Cellini, Miriam, Centanni, Marco, Gargano, Lucilla, Santaguida, MARIA GIULIA, Virili, Camilla   +6 more
core   +2 more sources

Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165.

Journal of Medicinal Chemistry, 2019
Small molecule JAK inhibitors have emerged as a major therapeutic advancement in treating autoimmune diseases. The discovery of isoform selective JAK inhibitors that traditionally target the catalytically active site of this kinase family has been a ...
Stephen T. Wrobleski, R. Moslin, S. Lin, Yanlei Zhang, S. Spergel, J. Kempson, J. Tokarski, J. Strnad, A. Zupa-Fernandez, Lihong Cheng, D. Shuster, Kathleen M. Gillooly, Xiaoxia Yang, Elizabeth M. Heimrich, K. McIntyre, C. Chaudhry, Javed A Khan, M. Ruzanov, J. Tredup, Dawn Mulligan, D. Xie, Huadong Sun, Christine S. Huang, C. D’arienzo, N. Araníbar, M. Chiney, A. Chimalakonda, W. Pitts, L. Lombardo, P. Carter, J. Burke, D. Weinstein   +31 more
semanticscholar   +1 more source

Evidence of blood–brain barrier dysfunction and CSF immunoglobulin synthesis in Down Syndrome Regression Disorder

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Objectives This study sought to evaluate proteomic, metabolomic, and immune signatures in the cerebrospinal fluid of individuals with Down Syndrome Regression Disorder (DSRD). Methods A prospective case–control study comparing proteomic, metabolomic, and immune profiles in individuals with DSRD was performed.
Jonathan D. Santoro, Neetha Paul Eduthan, Mellad M. Khoshnood, Saba Jafarpour, Natalie K. Boyd, Benjamin N. Vogel, Lina Nguyen, Lilia Kazerooni, Eleanor Britton, Hannah R. Lyford, Matthew D. Galbraith, Angela L. Rachubinski, Joaquin M. Espinosa   +12 more
wiley   +1 more source

Update on Vertigo in Autoimmune Disorders, from Diagnosis to Treatment [PDF]

, 2018
The prevalence of autoimmune diseases has been increasing over the last 20 years. The clinical presentation of this large and heterogeneous group of disorders depends on whether the involvement is organ-specific or non-organ-specific. Dizziness, vertigo,
Bovo, Roberto, Cazzador, Diego, Felicetti, Mara, Girasoli, Laura, Nardello, Ennio, Padoan, Roberto, Schiavon, Franco, Zanoletti, Elisabetta   +7 more
core   +1 more source

Assessment of concurrent neoplasms and a paraneoplastic association in MOGAD

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Cases of myelin oligodendrocyte glycoprotein (MOG) antibody‐associated disease (MOGAD) co‐occurring with neoplasms have been reported. In this international, retrospective cohort study in South Korea and the USA, 16 of 445 (3.6%) patients with MOGAD had concurrent neoplasm within 2 years of MOGAD onset, resulting in a standardized incidence ...
Young Nam Kwon, Nanthaya Tisavipat, Yong Guo, Stephanie B. Syc‐Mazurek, Ji Yeon Han, Jun‐Soon Kim, Kyomin Choi, Seong‐il Oh, Seok‐Jin Choi, Eunhee Sohn, Jeeyoung Oh, Seung Woo Kim, Ha Young Shin, Byung Chan Lim, Byoung Joon Kim, Kyung Seok Park, Jung‐Joon Sung, Se Hoon Kim, Sung‐Hye Park, Anastasia Zekeridou, Claudia F. Lucchinetti, Sean J. Pittock, John J. Chen, Eoin P. Flanagan, Sung‐Min Kim   +24 more
wiley   +1 more source

Neurological Consequences of COVID-19 Infection [PDF]

arXiv, 2021
COVID-19 infections have well described systemic manifestations, especially respiratory problems. There are currently no specific treatments or vaccines against the current strain. With higher case numbers, a range of neurological symptoms are becoming apparent.
arxiv  

Immunological and clinical effects of low-dose interleukin-2 across 11 autoimmune diseases in a single, open clinical trial

Annals of the Rheumatic Diseases, 2018
Objective Regulatory T cells (Tregs) prevent autoimmunity and control inflammation. Consequently, any autoimmune or inflammatory disease reveals a Treg insufficiency.
M. Rosenzwajg, R. Lorenzon, P. Cacoub, H. Pham, F. Pitoiset, Karim El Soufi, C. Ribet, C. Bernard, S. Aractingi, B. Banneville, L. Beaugerie, F. Berenbaum, J. Champey, O. Chazouilleres, C. Corpechot, B. Fautrel, A. Mékinian, E. Regnier, D. Saadoun, J. Salem, J. Sellam, P. Seksik, A. Daguenel-Nguyen, V. Doppler, Jérémie Mariau, E. Vicaut, D. Klatzmann   +26 more
semanticscholar   +1 more source

CSF cytokine, chemokine and injury biomarker profile of glial fibrillary acidic protein (GFAP) autoimmunity

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Defining the CSF cytokine/chemokine and injury biomarker signature of glial fibrillary acidic protein (GFAP) autoimmunity can inform immunopathogenesis. CSF GFAP‐IgG‐positive samples (N = 98) were tested for 17 cytokines/chemokines, neurofilament light chain (NfL), and GFAP (ELLA, Bio‐Techne).
Yahel Segal, Georgios Mangioris, Vanda Lennon, Binxia Yang, Divyanshu Dubey, Eoin P. Flanagan, Andrew McKeon, John R. Mills, Michel Toledano, Ivana Vodopivec, Sean J. Pittock, Anastasia Zekeridou   +11 more
wiley   +1 more source

Integrative genetic risk prediction using nonparametric empirical Bayes classification [PDF]

, 2016
Genetic risk prediction is an important component of individualized medicine, but prediction accuracies remain low for many complex diseases. A fundamental limitation is the sample sizes of the studies on which the prediction algorithms are trained.
arxiv   +1 more source