Results 261 to 270 of about 767,890 (335)

A Lung‐Immune Dual‐Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses

Advanced Science, EarlyView.
Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng, Jing Sun, Chun Lu, Qian Yu, Yiyun He, Bingqing Wu, Deshan Ren, Shuai Ding, Jincun Zhao, Yan Li   +9 more
wiley   +1 more source

The origin of autoimmune diseases: is there a role for ancestral HLA-II haplotypes in immune hyperactivity. [PDF]

Front Immunol
Ruiz-Pablos M, Paiva B, Zabaleta A.
europepmc   +1 more source

Leveraging artificial intelligence and machine learning for unraveling pathogenesis and advancing precision medicine in autoimmune diseases

Chunhao Cao, Wenting Zhao, Jianmin Guo, Zhuqian Wang, Aiping Lü, Chao Liang   +5 more
openalex   +2 more sources

Tubule‐Derived IFN‐α Promotes GSDMD‐Mediated Macrophage Pyroptosis to Drive Renal Inflammation and Fibrosis Through JAK2/STAT2 Activation

Advanced Science, EarlyView.
Mao and colleagues uncover a STAT2/IRF9‐dependent signaling axis through which tubular epithelial cell (TEC)‐derived IFN‐α induces gasdermin D (GSDMD)‐mediated pyroptosis in macrophages. This TEC‐macrophage feedback loop amplifies renal inflammation and fibrosis, providing mechanistic insight into the progression of chronic kidney disease and revealing
Yiping Xu, Yating Wang, Siming Jiang, Yi Li, Guanglan Li, Yuchu Liu, Siyuan Li, Yiming Zhou, Qinghua Liu, Yi Zhou, Wei Chen, Hongyu Li, Haiping Mao   +12 more
wiley   +1 more source

Exosomes in Autoimmunity: Mediators of Autoantigen Presentation and Targets for Therapeutic Intervention in Autoimmune Diseases. [PDF]

J Clin Immunol
Almohaimeed HM, Almars AI, Tounsi WA, Mohammedsaleh ZM, Panigrahi R, Singh I, Singh S, Dhara B, Uti DE.   +8 more
europepmc   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

The relationship between autoimmune diseases and temporomandibular disorders: A study combined with the GEO database. [PDF]

Medicine (Baltimore)
Gu F, Bao W, Zhao M, Huang W, Wu E, Yan X, Zheng H, Wang Y, Chen R.   +8 more
europepmc   +1 more source

A Biologically Informed Vision‐Guided Framework for Interpretable T Cell Receptor–Epitope Binding Prediction

Advanced Science, EarlyView.
Integrating hierarchical physicochemical features via a bio‐inspired design, the DAISY framework robustly predicts T‐cell receptor binding, significantly outperforming state‐of‐the‐art models on unseen epitopes. It uniquely offers visual interpretability via Score‐CAM visualizations and profound clinical relevance, correlating with T‐cell expansion ...
Yajing Yuan, Junwei Chen, Yufang Zhang, Yitian Fang, Zhongcheng Fang, Yanyi Chu, Jiayi Li, Chen Zhang, Yuzhe Li, Dongqing Wei   +9 more
wiley   +1 more source

Special Issue: Autoimmune Diseases: A Swing Dance of Immune Cells. [PDF]

Int J Mol Sci
Dzhambazov B.
europepmc   +1 more source

Genetically‐Programmed Hypervesiculation of Lactiplantibacillus Plantarum Increases Production of Bacterial Extracellular Vesicles with Therapeutic Efficacy in a Preclinical Inflammatory Bowel Disease Model

Advanced Science, EarlyView.
The development of a novel engineered strain of Lactiplantibacillus plantarum (Lp) is reported that can produce bacterial extracellular vesicles (BEVs) at >60‐fold higher yields than the unmodified parental strain. These Lp BEVs retain therapeutic bioactivity as validated in a mouse model of dextran sodium sulfate‐induced colitis.
Nicholas H Pirolli, Daniel Levy, Alyssa Schledwitz, Natalia Sampaio Moura, Mitali Sarkar, Talia J. Solomon, Emily H. Powsner, Raith Nowak, Zuzanna Mamczarz, Christopher J. Bridgeman, Sulayman Khan, Andrew Hui, Nidhi Anne, Laura Reus, William E. Bentley, Jean‐Pierre Raufman, Steven M. Jay   +16 more
wiley   +1 more source