Results 61 to 70 of about 49,621 (314)

Effects of viral and cytokine delays on dynamics of autoimmunity [PDF]

Mathematics 6, 66 (2018), 2018
A major contribution to the onset and development of autoimmune disease is known to come from infections. An important practical problem is identifying the precise mechanism by which the breakdown of immune tolerance as a result of immune response to infection leads to autoimmunity. In this paper, we develop a mathematical model of immune response to a
arxiv   +1 more source

Molecular mimicry of NMDA receptors may contribute to neuropsychiatric symptoms in severe COVID-19 cases [PDF]

, 2021
Approximately 30% of individuals with severe SARS-CoV-2 infections also develop neurological and psychiatric complaints. In rare cases, the occurrence of autoimmune encephalitis has been reported after SARS-CoV-2 infection.
Bernstein, H., Geis, C., Guest, P., Schroeter, M., Steiner, J., Vasilevska, V.   +5 more
core   +2 more sources

Anti-platelet factor 4/polyanion antibodies mediate a new mechanism of autoimmunity [PDF]

, 2020
Antibodies recognizing complexes of the chemokine platelet factor 4 (PF4-CXCL4) and polyanions (P) opsonize PF4-coated bacteria hereby mediating bacterial host defense. A subset of these antibodies may activate platelets after binding to PF4-heparin complexes, causing the prothrombotic adverse drug reaction heparin-induced thrombocytopenia (HIT).
arxiv   +1 more source

Hippocampal epileptogenesis in autoimmune encephalitis [PDF]

Annals of Clinical and Translational Neurology, 2019
AbstractObjectiveAutoantibody‐mediated forms of encephalitis (AE) include neurological disorders characterized by subacute memory loss, movement disorders, and, often, frequent, focal epileptic seizures. Yet, the electrophysiological effects of these autoantibodies on neuronal function have received little attention.
Arjune Sen, Arjune Sen, Michele Romoli, Michele Romoli, Nicola Biagio Mercuri, Nicola Tambasco, Paraskevi Krashia, Diego Franciotta, Paolo Calabresi, Lucilla Parnetti, Pasquale Nigro, Matteo Gastaldi, Elena Nardi Cesarini, Massimiliano Di Filippo, Annalisa Nobili, Andrea Mancini, Sarosh R. Irani, Cinzia Costa, Marcello D'Amelio   +18 more
openaire   +6 more sources

Symptomatic treatment of children with anti-NMDAR encephalitis. [PDF]

, 2016
AIM: We performed the first study on the perceived benefit and adverse effects of symptomatic management in children with anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis.
Brilot, F, Dale, R. C., Hong, M, Jones, H, Mohammad, Ss, Nosadini, M, Pillai, Sc, Sharpe, C   +7 more
core   +1 more source

Clinical characteristics, treatments, outcome, and prognostic factors of severe autoimmune encephalitis in the intensive care unit: Standard treatment and the value of additional plasma cell–depleting escalation therapies for treatment‐refractory patients

European Journal of Neurology, Volume 30, Issue 2, Page 474-489, February 2023., 2023
Our retrospective study analyzed 40 patients with intensive care unit (ICU)‐dependent autoimmune encephalitis (AE) for clinical characteristics, diagnostics, prognostic factors, and clinical outcomes regarding standard treatment in responsive patients versus additional escalation therapies for treatment‐refractory cases.
Lisa Schwarz, Nilufar Akbari, Harald Prüss, Andreas Meisel, Franziska Scheibe   +4 more
wiley   +1 more source

A Case Report on Autoimmune Encephalitis after Head Trauma [PDF]

, 2023
Background: Autoimmune inflammatory encephalitis is an inflammation of the brain characterized by prominent neuropsychiatric symptoms and are associated with antibodies against neuronal cell-surface proteins, ion channels, or receptors.
Ikwuezunma, Ashley, Uche, Chioma V
core  

Cytokine dynamics and targeted immunotherapies in autoimmune encephalitis [PDF]

, 2022
Autoimmune encephalitides constitute a diverse group of immune-mediated central nervous system disorders mainly characterized by the presence of antibodies targeting neuronal or glial antigens.
Birzu C., Ciano-Petersen N. L., Farina A., Honnorat J., Joubert B., Muniz-Castrillo S., Psimaras D., Villagran-Garcia M., Vogrig A.   +8 more
core   +1 more source

Neurological autoimmune diseases following vaccinations against severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2): A follow‐up study

European Journal of Neurology, Volume 30, Issue 2, Page 463-473, February 2023., 2023
In this study we define long‐term characteristics of various neurological autoimmune disorders encountered after SARS‐CoV‐2 vaccinations. Long‐term outcome was favorable in most cases. Re‐vaccinations were well‐tolerated and should be considered on an individual risk/benefit analysis.
Sofia Doubrovinskaia, Christoph M. Mooshage, Corinna Seliger, Hanns‐Martin Lorenz, Simon Nagel, Pascal Lehnert, Jan Purrucker, Brigitte Wildemann, Martin Bendszus, Wolfgang Wick, Silvia Schönenberger, Leon D. Kaulen   +11 more
wiley   +1 more source

Comparison of commercial and in-house tissue-based and cell-based assays for the detection of autoantibodies targeting neuronal surface proteins: a prospective cohort study

Frontiers in Immunology
IntroductionThe detection of antibodies targeting neuronal antigens is a keystone for the diagnosis of autoimmune encephalitis (AE) and paraneoplastic neurological syndromes (PNS).
David Goncalves, Marie Benaiteau, Marie Benaiteau, Véronique Rogemond, Véronique Rogemond, Sterenn Closs, Sterenn Closs, Anne-Laurie Pinto, Anne-Laurie Pinto, Maroua Dhairi, Maroua Dhairi, Marine Villard, Marine Villard, Géraldine Picard, Géraldine Picard, Nicole Fabien, Jérôme Honnorat, Jérôme Honnorat   +17 more
doaj   +1 more source