Results 61 to 70 of about 485,527 (247)

HLA‐B27 association of autoimmune encephalitis induced by PD‐L1 inhibitor

Annals of Clinical and Translational Neurology, 2020
Objective While immune checkpoint inhibitors are increasingly used for various cancers, unpredictable immune‐related adverse events (irAEs) such as autoimmune encephalitis is life‐threatening.
Hyeyeon Chang, Yong‐Won Shin, Bhumsuk Keam, Miso Kim, Seock‐Ah Im, Soon‐Tae Lee   +5 more
doaj   +1 more source

Autoimmune encephalitis followed by hemophagocytic lymph histiocytosis: a case report

Frontiers in Immunology
Objective This study aims to report three cases of autoimmune encephalitis followed by hemophagocytic lymphohistiocytosis. Methods Data of relevant patients treated between 2019 and 2022 were retrospectively collected from the Department of Neurology at ...
Li Huang, Jie Tan, Peihao Lin, Zixuan Chen, Qihua Huang, Haiyan Yao, Lihong Jiang, Baoyi Long, Youming Long   +8 more
semanticscholar   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Autoimmune encephalitis: what the radiologist needs to know

Neuroradiology
Autoimmune encephalitis is a relatively novel nosological entity characterized by an immune-mediated damage of the central nervous system. While originally described as a paraneoplastic inflammatory phenomenon affecting limbic structures, numerous ...
F. Sanvito, A. Pichiecchio, Matteo Paoletti, Giacomo Rebella, M. Resaz, Luana Benedetti, Federico Massa, S. Morbelli, E. Caverzasi, C. Asteggiano, Pietro Businaro, Stefano Masciocchi, L. Castellan, D. Franciotta, M. Gastaldi, L. Roccatagliata   +15 more
semanticscholar   +1 more source

Structural mechanisms of GABAA receptor autoimmune encephalitis.

Cell, 2022
Autoantibodies targeting neuronal membrane proteins can cause encephalitis, seizures, and severe behavioral abnormalities. While antibodies for several neuronal targets have been identified, structural details on how they regulate function are unknown ...
C. Noviello, J. Kreye, J. Teng, H. Prüss, R. Hibbs   +4 more
semanticscholar   +1 more source

Patterns of Postictal Abnormalities in Relation to Status Epilepticus in Adults

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Abnormalities on peri‐ictal diffusion‐weighted magnetic resonance imaging (DWI‐PMAs) are well‐established for patients with status epilepticus (SE), but knowledge on patterns of DWI‐PMAs and their prognostic impact is sparse. Methods This systematic review and individual participant data meta‐analysis included observational studies ...
Andrea Enerstad Bolle, Silvana Sarria‐Estrada, Thomas Bonduelle, Bertram Daniel Dynesen, Manuel Toledo, Zhu Chung Che, Kjell Heuser, Anastasios Chatzikonstantinou, Jérôme Aupy, Udaya Seneviratne, Estevo Santamarina Perez, Christoph Patrick Beier   +11 more
wiley   +1 more source

Anti-PD1-/PDL1-induced chronic intestinal pseudo-obstruction: three cases treated with vedolizumab after corticosteroid failure with mixed results

Cancer Immunology, Immunotherapy
Immune checkpoint inhibitors (ICI), i.e., anti-PD1/PDL1 and anti-CTLA-4, have reshaped the prognosis of many cancers. Increased use of ICI has led to the onset of new adverse events.
Morgan Zenatri, Michael Collins, Tifanie Alberto, Antonio Farina, Sophie Collardeau-Frachon, Mélanie Saint-Jean, François Bocquet, Frederic Dumont, Jérôme Honnorat, Bastien Joubert, Judith Raimbourg   +10 more
doaj   +1 more source

A case of anti-VGKC antibody encephalitis and prolonged encephalopathy despite spontaneous resolution of imaging abnormalities

Journal of Community Hospital Internal Medicine Perspectives, 2020
Anti-voltage-gated potassium channel (anti-VGKC) antibody encephalitis is a common form of autoimmune encephalitis (AE). AE is usually associated with autoimmune diseases or paraneoplastic phenomena such as seen in small cell lung cancer.
Victoria Novoselova, Vikas Kumar, Niranjan N. Singh, Alexandre Lacasse   +3 more
doaj   +1 more source

Canadian Consensus Guidelines for the Diagnosis and Treatment of Autoimmune Encephalitis in Adults

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
Autoimmune encephalitis is increasingly recognized as a neurologic cause of acute mental status changes with similar prevalence to infectious encephalitis.
Chris Hahn, A. Budhram, K. Alikhani, Nasser Alohaly, Grayson Beecher, Gregg Blevins, John Brooks, Robert Carruthers, J. Comtois, Juthaporn Cowan, Paula de Robles, Julien Hébert, Ronak K. Kapadia, Sarah Lapointe, A. Mackie, Warren Mason, Brienne McLane, A. Muccilli, Ilia Poliakov, Penelope Smyth, K. Williams, Christopher E Uy, J. Mccombe   +22 more
semanticscholar   +1 more source

Clinical Spectrum and Outcomes of SOX1 Antibody‐Associated Paraneoplastic Neurological Syndromes: A Chinese Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background SOX1 antibody‐positive paraneoplastic neurological syndromes (PNS) exhibit significant population‐specific clinical heterogeneity. While Western cohorts predominantly manifest Lambert‐Eaton myasthenic syndrome (65%–80%), comprehensive clinical characterization and treatment response data in Asian populations remain critically ...
Jin‐Long Ye, Zu‐Ying Kuang, Bo Li, Meng‐Qiu Pan, Li‐Hua Zhou, Yang‐Yang Dai, Si‐Fen Xie, Xian‐Guang Lin, Ye‐Peng Hu, Li‐Hong Jiang, Zhan‐Hang Wang, Wei‐Jing Zhang   +11 more
wiley   +1 more source