Results 211 to 220 of about 173,185 (344)

The depletion of serine beta‐lactamase‐like protein (LACTB) ameliorates metabolic dysfunction–associated steatotic liver disease by reducing ubiquitin‐mediated degradation of carnitine palmitoyltransferase 2

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Metabolic dysfunction–associated steatotic liver disease (MASLD) represents one of the most common chronic liver disorders worldwide, and its incidence continues to rise each year. Serine β‐lactamase‐like protein (LACTB) is a serine protease that plays a crucial role in lipid metabolism and hepatocellular carcinoma, but its function in ...
Wujiang Shi   +10 more
wiley   +1 more source

CLEC18A interacts with sulfated glycosaminoglycans and controls clear cell renal cell carcinoma progression

open access: yesThe FEBS Journal, EarlyView.
CLEC18A is a previously poorly characterized C‐type lectin. We mapped the expression of CLEC18A to the proximal tubule of the kidney and found CLEC18A to interact with sulfated glycosaminoglycans on proteoglycans. Furthermore, we found that CLEC18A plays an important role in hindering the progression of clear cell renal cell carcinomas in humans and in
Gustav Jonsson   +10 more
wiley   +1 more source

Steatotic Liver Disease: A Key Related Risk Factor in the Emergence of Metabolic Syndrome‐Related Disorders

open access: yesHepatology Research, EarlyView.
It is speculated that the onset of obesity‐related diseases follows the sequence of obesity → SLD → MetS‐related diseases. In this study, the contribution of SLD to each MetS‐related disease was large for T2D and hypertension and SLD contributed to the onset and new onset of the disease by the 7‐year follow‐up.
Yoshihiro Kamada   +6 more
wiley   +1 more source

A case of autoimmune hepatitis associated with Graves' disease.

open access: bronze, 1986
Kazuhiro Goto   +6 more
openalex   +2 more sources

Autoimmune Hepatitis: Histopathological Diversity and Its Clinical Implications

open access: yesHepatology Research, EarlyView.
ABSTRACT Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease characterized by diverse clinical and histological manifestations. Accurate histopathological evaluation plays a critical role in determining disease activity, guiding treatment strategies, and predicting prognosis.
Mina Komuta, Kenichi Harada
wiley   +1 more source

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