Results 191 to 200 of about 112,037 (251)

Clinical Outcomes of Gradual Corticosteroid Tapering for Immune Checkpoint Inhibitor‐Induced Liver Injury

Hepatology Research, EarlyView.
Patients with severe ICI‐induced liver injury are commonly treated with corticosteroids, but the optimal tapering strategy remains uncertain. In this study, a gradual corticosteroid tapering strategy based partly on Japanese clinical practice for autoimmune hepatitis was associated with a low rate of relapse and enabled many patients to safely resume ...
Naoto Soma, Yoshihito Uchida, Kayoko Sugawara, Masamitsu Nakao, Nobuaki Nakayama, Yukinori Imai, Suguru Mizuno, Satoshi Mochida   +7 more
wiley   +1 more source

Artificial intelligence predicts recurrent autoimmune hepatitis after liver transplantation in a multicenter cohort study. [PDF]

Hepatol Commun
Bhat M, Sun Y, Manickavel P, Maleki S, Ronca V, Hansen BE, Hirschfield G, Elwir S, Alsaed M, Milkiewicz P, Janik MK, Marschall HU, Burza MA, Efe C, Calışkan AR, Harputluoglu M, Kabaçam G, Terrabuio D, de Quadros Onofrio F, Selzner N, Bonder A, Parés A, Llovet L, Akyıldız M, Arikan C, Manns MP, Taubert R, Weber AL, Schiano TD, Haydel B, Czubkowski P, Socha P, Ołdak N, Akamatsu N, Tanaka A, Levy C, Martin EF, Goel A, Sedki M, Jankowska I, Ikegami T, Rodriguez M, Sterneck M, Weiler-Normann C, Schramm C, Donato MF, Lohse A, Andrade RJ, Patwardhan VR, van Hoek B, Biewenga M, Kremer AE, Ueda Y, Deneau M, Pedersen M, Mayo MJ, Floreani A, Burra P, Secchi MF, Terziroli Beretta-Piccoli B, Sciveres M, Maggiore G, Jafri SM, Debray D, Girard M, Lacaille F, de Boer YS, Lleo A, Mason AL, Heneghan M, Oo YH, Lytvyak E, Montano-Loza AJ, International AIH Study Group.   +73 more
europepmc   +1 more source

Validation of the Baveno Endoscopy Avoidance Criteria in Japanese Patients With Chronic Liver Disease: A Real‐World Cohort Study

Hepatology Research, EarlyView.
Many patients with chronic liver disease can safely avoid unnecessary screening endoscopy using the Baveno VII criteria. We developed a simple three‐factor score to identify patients at high risk of serious esophageal varices. Using both approaches together may improve the efficiency and safety of endoscopic screening.
Maiko Asami, Yoshihito Uchida, Shohei Tsuji, Satsuki Ando, Kayoko Sugawara, Masamitsu Nakao, Nobuaki Nakayama, Yukinori Imai, Suguru Mizuno, Satoshi Mochida   +9 more
wiley   +1 more source

"From Cholestasis to Interface Hepatitis: A Rare Case of Primary Sclerosing Cholangitis-Autoimmune Hepatitis Overlap in a 20-Year-Old Male". [PDF]

Clin Med Insights Case Rep
Shah MH, Sethi AD, Osama M, Hasnain S, Shah R, Khan I, Khan A, Thada PK.   +7 more
europepmc   +1 more source

Discordance Between Japanese and European Definitions of Acute‐on‐Chronic Liver Failure in Alcohol‐Related Cirrhosis: Insights From a 10‐Year Consecutive Cohort

Hepatology Research, EarlyView.
Substantial discordance was observed between Japanese and EASL‐CLIF definitions of acute‐on‐chronic liver failure in alcohol‐related cirrhosis. Many Japanese‐defined cases were classified as EASL‐CLIF grade 0 yet retained non‐negligible 1‐year mortality, highlighting the complementary roles of hepatic‐based and organ failure–based frameworks.
Hidehiro Kamezaki, Nana Yamada, Terunao Iwanaga, Takafumi Sakuma, Koji Takahashi, Junichi Senoo, Makoto Arai, Tatsuo Kanda, Sadahisa Ogasawara, Jun Kato   +9 more
wiley   +1 more source

Mapping of class II HLA restriction of SepSecS-specific CD4 T-cell epitopes in autoimmune hepatitis. [PDF]

JHEP Rep
Guinebretière T, Garcia A, Dong C, Bernier L, Huchet V, Gavlovsky PJ, Gil L, Ado S, David L, Chevalier C, Judor JP, Clémenceau B, Khaldi M, Bardou-Jacquet E, Elkrief L, Lannes A, Silvain C, Schnee M, Tanne F, Lemoinne S, De Martin E, Plessier A, Vavasseur F, Laplaud DA, Kwok WW, Brouard S, Mosnier JF, Gournay J, Milpied P, Conchon S, Renand A.   +30 more
europepmc   +1 more source

Histological manifestations of vitamin A toxicity in the liver

Histopathology, EarlyView.
Analysing clinicopathological data from 1960 to 2025, this study characterizes the spectrum of liver injury associated with chronic vitamin A toxicity. Hepatic stellate cell hypertrophy/hyperplasia and sinusoidal fibrosis emerge as the predominant features, providing a morphological basis for diagnosing vitamin A hepatotoxicity.
Giorgio Cazzaniga, Georg Lietz, Dina G. Tiniakos   +2 more
wiley   +1 more source

The bacteroidal metabolite O-LysoPE facilitates hepatocyte-mediated immunosuppression in autoimmune hepatitis. [PDF]

Nat Commun
Xu M, Luo K, Zhou Z, Li J, Zhang S, Kong L, Jiang L, Zhang Y, Li Y, Xiao F, Zhu C, Xu Q, Yi H, Wu X.   +13 more
europepmc   +1 more source

Cyclin‐dependent kinase 4/6 (CDK4/6) inhibitor‐induced hepatotoxicity and its resolution: a study of seven cases

Histopathology, EarlyView.
CDK4/6 inhibitor‐induced liver injury represents a clinically significant and histologically distinctive form of drug‐induced hepatotoxicity, most commonly encountered with ribociclib. The predominant pattern is severe acute hepatocellular injury, frequently accompanied by lymphocytic cholangitis, a combination that, in the appropriate clinical context,
Sunayana Misra, Lisa Centeno, Dupinder Singh, Romil Saxena, Rifat Mannan   +4 more
wiley   +1 more source

Interleukin-17 in Health and Disease: Special Focus on Its Role in Autoimmune Hepatitis. [PDF]

Cells
Agoston Ş, Grama A, Onaciu A, Mititelu A, Benţa G, Pop TL.   +5 more
europepmc   +1 more source