Results 61 to 70 of about 173,185 (344)

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Clinical characteristics and outcome of patients with autoimmune hemolytic anemia (AIHA) uniformly defined as primary by a diagnostic work-up [PDF]

, 2016
Primary autoimmune hemolytic anemia (P-AIHA) is a relatively uncommon and hetereogeneous disease characterized by the destruction of red blood cells due to anti-erythrocyte autoantibodies (AeAbs) in the absence of an associated disease [1–3].
ARMIENTO, DANIELE, CARONNA, Roberto, COLAFIGLI, GIOIA, Coluzzi, S, De Propris, Ms, FERRETTI, ANTONIETTA, FOA, Roberto, GIOVANNETTI, GIANLUCA, GIRELLI, Gabriella, GUARINI, Anna, LA ROCCA, URSULA, MAURO, Francesca Romana, MOLICA, MATTEO, Morano, G, Paoloni, F, Trastulli, F   +15 more
core   +1 more source

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

Acute Jaundice in a Six-year-old: An Unusual Presentation of Atypical Kawasaki Disease [PDF]

, 2020
Kawasaki disease (KD) is a rare vasculitis of childhood that is critical to recognize and treat due to associated morbidity and mortality. A six-year-old male presented to our emergency department (ED) afebrile but with reported recent fevers.
Bylund, LCDR William, Morrison Ponce, LCDR Daphne, Zarow, Gregory J.   +2 more
core  

p16Ink4a‐Positive Hepatocytes Drive Liver Fibrosis Through Activation of LIFR Family Pathway

Advanced Science, EarlyView.
This study found that, following the long‐term CCl4 treatment, p16high hepatocytes appeared in zone 3, spatially co‐localizing with fibrotic areas. A specific cluster of p16high hepatocytes upregulated CTF1/LIF expression which induced HSC activation and further liver fibrosis, as revealed by single cell transcriptomic analysis.
Koji Nishikawa, Teh‐Wei Wang, Satoshi Kawakami, Shota Tanimoto, Kiyoshi Yamaguchi, Taketomo Kido, Masamichi Kimura, Tsunekazu Hishima, Yuki T. Okamura, Satotaka Omori, Takumi Iritani, Toshikaze Chiba, Takehiro Jimbo, Michio Katano, Kansuporn Kamataki, Ryoichi Yokoyama, Eigo Shimizu, Kiminori Kimura, Satoshi Yamzaki, Seiya Imoto, Yoichi Furukawa, Atsushi Miyajima, Yoshikazu Johmura, Makoto Nakanishi   +23 more
wiley   +1 more source

Drug-induced hepatitis superimposed on the presence of anti-SLA antibody: a case report

Journal of Medical Case Reports, 2008
Introduction Autoimmune hepatitis is a necroinflammatory disorder of unknown etiology characterized by the presence of circulating antibodies, hypergammaglobulinemia, and response to immunosuppression.
Etxagibel Aitziber, Julià M Rosa, Brotons Alvaro, Company M Margarita, Dolz Carlos   +4 more
doaj   +1 more source

Functional diversity of chemokines and chemokine receptors in response to viral infection of the central nervous system. [PDF]

, 2006
Encounters with neurotropic viruses result in varied outcomes ranging from encephalitis, paralytic poliomyelitis or other serious consequences to relatively benign infection.
A. Meyer, A.A. Dandekar, A.D. Luster, B. Mehrad, B. Parra, B. Parra, B.D. Pearce, B.P. Chen, B.T. Fife, C. Gerard, C. Ramakrishna, C. Ramakrishna, C.A. Biron, C.E. Patterson, C.J. Raport, C.M. Hogaboam, D. Franciotta, D. Galimberti, D. Whiting, D.D. Taub, D.J. Mahad, D.M. Muller, D.N. Cook, D.P. Widney, E. Lazzeri, E.J. McMahon, F.R. Fischer, F.S. Cheever, G. Penna, G. Penna, G.B. Huffnagle, G.C. Hildebrandt, G.F. Wu, H. Bartosik-Psujek, H.G. Fischer, H.G. Fischer, I. Banisor, I. Clark-Lewis, I. Salomon, I. Tsunoda, I.E. Flesch, J. Gosling, J.B. Domachowske, J.C. Houck, J.F. Bazan, J.H. Dufour, J.H. Xie, J.J. Phillips, J.M. Farber, J.S. Haring, J.S. Haring, J.S. Williamson, J.S. Williamson, K. Holmes, K. McIntosh, K.E. Balashov, K.S. Held, K.S. Warmington, K.V. Holmes, L. Boring, L. Boring, L. Cartier, L. Gu, L. Gu, L. Pewe, L. Pewe, M. Baggiolini, M. Greter, M. Matsui, M.A. Olszewski, M.J. Buchmeier, M.J. Trifilo, M.J. Trifilo, M.J. Trifilo, M.M. Lai, M.T. Lin, M.T. Lin, M.T. Liu, M.T. Liu, M.T. Liu, N. Sato, N.J. Megjugorac, N.W. Marten, R. Gade-Andavolu, R. Watanabe, R.F. Castro, R.S. Klein, S. Narumi, S. Qin, S. Xue, S.A. Stohlman, S.A. Stohlman, S.D. Miller, S.M. Stamatovic, S.R. Perlman, T.E. Lane, T.E. Lane, T.E. Lane, T.L. Sorensen, T.L. Sorensen, T.S. Kim, T.S. Kim, W.G. Glass, W.G. Glass, W.G. Glass, W.G. Glass, W.J. Karpus, Y. Zhang, Y. Zhou   +108 more
core   +1 more source

Grand round: Autoimmune hepatitis [PDF]

Journal of Hepatology, 2019
Autoimmune hepatitis is a corticosteroid-responsive liver disease arising consequent to immunogenetic and environmental risk factors. The clinical course reflects relapsing and remitting, hepatocyte targeted immunologic damage, which is countered by reparative responses to cell injury. Appropriate and timely immunosuppressive therapy drives the disease
Palak J. Trivedi, Stefan G. Hubscher, Michael Heneghan, Dermot Gleeson, Gideon M. Hirschfield   +4 more
openaire   +5 more sources

Parabiosis, Assembloids, Organoids (PAO)

Advanced Science, EarlyView.
This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong, Lavonda Li, Lijie Yan, Long Bai, Jiacan Su, Xingcai Zhang   +5 more
wiley   +1 more source

Classical autoimmune hepatitis and the IgG4-associated autoimmune hepatitis in paediatric patients

Polish Journal of Pathology
The IgG4-associated autoimmune hepatitis (IgG4-AIH) is a newly proposed disease entity characterised by the accumulation of the IgG4-expressing plasma cells in the liver. Its pathophysiology and clinical significance remain unclear and have poor evidence
Dominika Kaps-Kopiec, Małgorzata Woźniak, Dorota Jarzębicka, Renata Grzywa-Czuba, Joanna Pawłowska, Piotr Czubkowski, Joanna Cielecka-Kuszyk   +6 more
doaj   +1 more source