Results 31 to 40 of about 436,604 (311)

TREATMENT OF UVEITIS ASSOCIATED WITH SYSTEMIC AUTOIMMUNE DISEASES IN ADULTS: A CONCISE OVERVIEW [PDF]

Romanian Journal of Rheumatology, 2017
Uveitis represents a heterogenous group of inflammatory ocular diseases which may cause vision loss. Association of uveitis with arthritis may occur in many systemic autoimmune diseases, including spondyloarthritis, juvenile idiopathic arthritis, Behҫet ...
Laura Muntean, Simona Rednic
doaj   +1 more source

TNF-α in Uveitis: From Bench to Clinic

Frontiers in Pharmacology, 2021
Uveitis is an inflammation of the iris, ciliary body, vitreous, retina, or choroid, which has been shown to be the first manifestation of numerous systemic diseases.
Qi Jiang, Zhaohuai Li, Tianyu Tao, Runping Duan, Xianggui Wang, Xianggui Wang, Wenru Su   +6 more
doaj   +1 more source

METTL3 inhibits autoreactive Th17 cell responses in experimental autoimmune uveitis via stabilizing ASH1L mRNA

The FASEB Journal, 2023
Methyltransferase like 3 (METTL3), a primary N6‐methyladenosine (m6A) methyltransferase, has been implicated in various biological and pathological processes including immune responses.
Lu Zhao, Yuling Liu, Binyun Ma, Xun Liu, R. Wei, Hong Nian   +5 more
semanticscholar   +1 more source

Multicellular immune dynamics implicate PIM1 as a potential therapeutic target for uveitis

Nature Communications, 2022
Uveitis is a complex autoimmune inflammatory disease of the eye and defining molecules involved is a priority. Here the authors use scRNA sequencing in mouse experimental autoimmune uveitis (EAU) and show PIM1 promotes the imbalance of Th17 and Treg ...
He Li, Lihui Xie, Lei Zhu, Zhaohuai Li, Rong Wang, Xiuxing Liu, Zhaohao Huang, Binyao Chen, Yuehan Gao, Lai Wei, Chang He, Rong Ju, Yizhi Liu, Xialin Liu, Yingfeng Zheng, Wenru Su   +15 more
doaj   +1 more source

Retinal glycoprotein enrichment by concanavalin a enabled identification of novel membrane autoantigen synaptotagmin-1 in equine recurrent uveitis. [PDF]

, 2012
Complete knowledge of autoantigen spectra is crucial for understanding pathomechanisms of autoimmune diseases like equine recurrent uveitis (ERU), a spontaneous model for human autoimmune uveitis. While several ERU autoantigens were identified previously,
A Lux, AK Berntson, AK Steck, B Wiggert, Barbara Amann, BD McNeil, BM Spiess, C Eberhardt, C Kiel, CA Deeg, CA Deeg, CA Deeg, CA Deeg, CA Deeg, CA Deeg, CA Deeg, CA Deeg, CM Kalsow, Cornelia A. Deeg, CW Morgans, D Josic, D Schubert, ER Chapman, G Glavan, H de Wit, Hassan Y. Naim, HY Naim, J Petersen, J Ratelade, JK Zipplies, JP Collin, JW Becker, K Marino, KF Greif, KS Shamsi, LN Troelsen, Lucienne Chatenoud, M Mirshahi, M Takamori, M Takamori, M Takamori, M Takamori, M Vrljic, M Zhao, MA Koontz, Margarete E. Swadzba, MC Ehrenhofer, MC Kwok, MC Papadopoulos, ME Swadzba, MJ Lewis, N Martin-Moutot, P Ariel, P David, P Redecker, RA Levy, RL Degroote, RR Caspi, S Bohm, SM Hauck, SM Hauck, Stefanie M. Hauck, V Gauba, VA Lennon, VA Lennon, W Han, W Vennekate, XQ Liu, Y Wang   +68 more
core   +6 more sources

Gut microbiota-mediated secondary bile acids regulate dendritic cells to attenuate autoimmune uveitis through TGR5 signaling.

Cell Reports, 2021
Gut microbiota-mediated secondary bile acids (BAs) play an important role in energy balance and host metabolism via G protein-coupled receptors and/or nuclear receptors.
Jianping Hu, Chaokui Wang, Xinyue Huang, S. Yi, Su Pan, Yiting Zhang, G. Yuan, Qingfeng Cao, Xingsheng Ye, Hong Li   +9 more
semanticscholar   +1 more source

Integrated Transcriptome Analysis of Iris Tissues in Experimental Autoimmune Uveitis

Frontiers in Genetics, 2022
Uveitis is a severe ocular inflammatory disease that affects the uvea and frequently results in visual impairment, even irreversible blindness. The current treatments for uveitis have exhibited adverse side effects. To find novel targets of this disease,
Dan Li, Dan Li, Dan Li, Dan Li, Chang Huang, Chang Huang, Chang Huang, Chang Huang, Xiaoyan Han, Xiaoyan Han, Xiaoyan Han, Xiaoyan Han, Jianguo Sun, Jianguo Sun, Jianguo Sun, Jianguo Sun   +15 more
doaj   +1 more source

Galectin-3 regulates microglial activation and promotes inflammation through TLR4/MyD88/NF-kB in experimental autoimmune uveitis.

Clinical Immunology, 2022
Galectin-3, an attractive molecule of innate immunity, has been reported to be involved in the neuroinflammatory diseases. However, the role of Galectin-3 in autoimmune uveitis is still unclear. The purpose of this study was to investigate the effect and
Yusen Liu, Chenyang Zhao, Jiayu Meng, Na Li, Zongren Xu, Xianyang Liu, Shengping Hou   +6 more
semanticscholar   +1 more source

Fe-curcumin nanozyme-mediated immunosuppression and anti-inflammation in experimental autoimmune uveitis

Biomaterials Research, 2023
Background EAU is an inflammatory disease usually characterized by autoinflammation and autoimmunity and is aggravated by excessive generation of ROS. Conventional hormone therapy often has more adverse effects.
Zhengxuan Jiang, Kun Liang, Xiang Gao, Fan Cao, G. An, Si-qian Gui, W. Tang, Liping Du, Liming Tao, Xianwen Wang   +9 more
semanticscholar   +1 more source

Atopobiosis and Dysbiosis in Ocular Diseases: Is Fecal Microbiota Transplant and Probiotics a Promising Solution?

Journal of Ophthalmic & Vision Research, 2021
Purpose: To highlight the role of atopobiosis and dysbiosis in the pathomechanism of autoimmune uveitis, therefore supporting fecal microbiota transplant (FMT) and probiotics as potential targeted-treatment for uveitis.
Triana Hardianti Gunardi, Diannisa Paramita Susantono, Andi Arus Victor, Ratna Sitompul   +3 more
doaj   +1 more source