Results 91 to 100 of about 339,261 (412)
Glassy Dynamics in the Adaptive Immune Response Prevents Autoimmune Disease [PDF]
, 2005 The immune system normally protects the human host against death by infection. However, when an immune response is mistakenly directed at self antigens, autoimmune disease can occur. We describe a model of protein evolution to simulate the dynamics of the adaptive immune response to antigens.
arxiv +1 more source
MIRACLE: Multi-task Learning based Interpretable Regulation of Autoimmune Diseases through Common Latent Epigenetics [PDF]
arXiv, 2023 DNA methylation is a crucial regulator of gene transcription and has been linked to various diseases, including autoimmune diseases and cancers. However, diagnostics based on DNA methylation face challenges due to large feature sets and small sample sizes, resulting in overfitting and suboptimal performance. To address these issues, we propose MIRACLE,
arxiv
Mechanism-based strategies for the management of autoimmunity and immune dysregulation in primary immunodeficiencies [PDF]
, 2016 A broad spectrum of autoimmunity is now well described in patients with primary immunodeficiencies (PIDs). Management of autoimmune disease in the background of PID is particularly challenging given the seemingly discordant goals of immune support and ...
Cooper, Megan A +4 more
core +2 more sources
FEBS Open Bio, EarlyView.Etoposide, a topoisomerase II inhibitor, reduces O‐GlcNAcylation in HepG2 liver cancer cells. Further inhibition of O‐GlcNAc transferase by OSMI‐1 enhanced etoposide‐induced apoptosis, lowering the IC50 for viability and increasing the EC50 for cytotoxicity.
Jaehoon Lee +5 more
wiley +1 more source
Regulation of Syk activity by antiviral adaptor MAVS in FcεRI signaling pathway
Frontiers in Allergy, 2023 BackgroundMast cells are the major effector cell type for IgE-mediated allergic reactions. Recent studies revealed a role for mast cells in orchestrating the host response to viral infections.ObjectiveWe studied the relationship between FcεRI (high ...
Yuko Kawakami +7 more
doaj +1 more source
Bifurcations and multi-stability in a model of cytokine-mediated autoimmunity [PDF]
, 2018 This paper investigates the dynamics of immune response and autoimmunity with particular emphasis on the role of regulatory T cells (Tregs), T cells with different activation thresholds, and cytokines in mediating T cell activity. Analysis of the steady states yields parameter regions corresponding to regimes of normal clearance of viral infection ...
arxiv +1 more source
Nature Communications, 2020 Autoimmune connective tissue diseases arise in a stepwise fashion from asymptomatic preclinical autoimmunity. Type I interferons have a crucial role in the progression to established autoimmune diseases.
A. Psarras +8 more
semanticscholar +1 more source
Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes. [PDF]
, 1996 We previously demonstrated that a spontaneous Th1 response against glutamate decarboxylase (GAD65) arises in NOD mice at four weeks in age and subsequently T cell autoimmunity spreads both intramolecularly and intermolecularly.
Atkinson, MA +6 more
core
FEM1B enhances TRAIL‐induced apoptosis in T lymphocytes and monocytes
FEBS Open Bio, EarlyView.FEM1B facilitates TRAIL‐induced apoptosis through distinct mechanisms in T lymphocytes and monocytes. In T lymphocytes, FEM1B engages with TRAF2, leading to a reduction in TRAF2 expression, which subsequently lessens TRAF2's inhibitory influence on caspase‐8.
Chenbo Yang +5 more
wiley +1 more source
Scientific Reports, 2018 Chronic obstructive pulmonary disease (COPD) is a serious global health problem characterized by chronic airway inflammation, progressive airflow limitation and destruction of lung parenchyma.
Ulf Hedström +6 more
doaj +1 more source