Results 91 to 100 of about 207,009 (370)

Commensal orthologs of the human autoantigen Ro60 as triggers of autoimmunity in lupus

Science Translational Medicine, 2018
Commensal bacterial orthologs of the human autoantigen Ro60 may trigger cross-reactive T and B cells that initiate and sustain chronic autoimmunity in lupus.
T. Greiling, C. Dehner, Xinguo Chen, K. Hughes, A. Iñiguez, M. Boccitto, Daniel Zegarra Ruiz, Stephen C Renfroe, S. Vieira, W. Ruff, S. Sim, C. Kriegel, Julia R Glanternik, Xindi Chen, M. Girardi, P. Degnan, K. Costenbader, A. Goodman, S. Wolin, M. Kriegel   +19 more
semanticscholar   +1 more source

Speciation due to hybrid necrosis in plant-pathogen models [PDF]

Evolution v. 63, December 2009, pp.: 3076-3084, 2009
We develop a model for speciation due to postzygotic incompatibility generated by autoimmune reactions. The model is based on predator-prey interactions between a host plants and their pathogens. Such interactions are often frequency-dependent, so that pathogen attack is focused on the most abundant plant phenotype, while rare plant types may escape ...
arxiv   +1 more source

Sarcoidosis as an Autoimmune Disease

Frontiers in Immunology, 2020
Despite the large number of performed studies, the etiology and pathogenesis of sarcoidosis still remain unknown. Most researchers allude to the possible autoimmune or immune-mediated genesis of the disease.
Anna A. Starshinova, Anna M. Malkova, Natalia Y. Basantsova, Natalia Y. Basantsova, Yulia S. Zinchenko, Yulia S. Zinchenko, Igor V. Kudryavtsev, Igor V. Kudryavtsev, Igor V. Kudryavtsev, Gennadiy A. Ershov, Lidia A. Soprun, Vera A. Mayevskaya, Leonid P. Churilov, Leonid P. Churilov, Piotr K. Yablonskiy, Piotr K. Yablonskiy   +15 more
doaj   +1 more source

The roles of metabolic profiles and intracellular signaling pathways of tumor microenvironment cells in angiogenesis of solid tumors

Cell Communication and Signaling, 2022
Innate and adaptive immune cells patrol and survey throughout the human body and sometimes reside in the tumor microenvironment (TME) with a variety of cell types and nutrients that may differ from those in which they developed.
Hamidreza Zalpoor, Fatemeh Aziziyan, Mahsa Liaghat, Maryam Bakhtiyari, Abdullatif Akbari, Mohsen Nabi-Afjadi, Razieh Forghaniesfidvajani, Nima Rezaei   +7 more
doaj   +1 more source

The role of tunable activation thresholds in the dynamics of autoimmunity [PDF]

J. Theor. Biol. 308, 45-55 (2012), 2012
It has been known for some time that human autoimmune diseases can be triggered by viral infections. Several possible mechanisms of interactions between a virus and immune system have been analysed, with a prevailing opinion being that the onset of autoimmunity can in many cases be attributed to "molecular mimicry", where linear peptide epitopes ...
arxiv  

Differential action of TIGIT on islet and peripheral nerve autoimmunity in the NOD mouse [PDF]

arXiv, 2023
We previously demonstrated that the abrogation of the ICOS pathway prevents type 1 diabetes development in the Non Obese Diabetic (NOD) mouse, but results in a CD4+ T-cell dependent autoimmune neuromyopathy in aged mice. Pancreatic islet infiltrates in conventional NOD mice and neuromuscular infiltrates in Icosl-/- NOD mice have in common that they ...
arxiv  

Evidence of blood–brain barrier dysfunction and CSF immunoglobulin synthesis in Down Syndrome Regression Disorder

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Objectives This study sought to evaluate proteomic, metabolomic, and immune signatures in the cerebrospinal fluid of individuals with Down Syndrome Regression Disorder (DSRD). Methods A prospective case–control study comparing proteomic, metabolomic, and immune profiles in individuals with DSRD was performed.
Jonathan D. Santoro, Neetha Paul Eduthan, Mellad M. Khoshnood, Saba Jafarpour, Natalie K. Boyd, Benjamin N. Vogel, Lina Nguyen, Lilia Kazerooni, Eleanor Britton, Hannah R. Lyford, Matthew D. Galbraith, Angela L. Rachubinski, Joaquin M. Espinosa   +12 more
wiley   +1 more source

Genetic risk for autoimmunity is associated with distinct changes in the human gut microbiome

Nature Communications, 2019
Susceptibility to many human autoimmune diseases is under strong genetic control by class II human leukocyte antigen (HLA) allele combinations. These genes remain by far the greatest risk factors in the development of type 1 diabetes and celiac disease ...
J. T. Russell, L. Roesch, Malin Ördberg, J. Ilonen, M. Atkinson, D. Schatz, E. Triplett, J. Ludvigsson   +7 more
semanticscholar   +1 more source

Assessment of concurrent neoplasms and a paraneoplastic association in MOGAD

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Cases of myelin oligodendrocyte glycoprotein (MOG) antibody‐associated disease (MOGAD) co‐occurring with neoplasms have been reported. In this international, retrospective cohort study in South Korea and the USA, 16 of 445 (3.6%) patients with MOGAD had concurrent neoplasm within 2 years of MOGAD onset, resulting in a standardized incidence ...
Young Nam Kwon, Nanthaya Tisavipat, Yong Guo, Stephanie B. Syc‐Mazurek, Ji Yeon Han, Jun‐Soon Kim, Kyomin Choi, Seong‐il Oh, Seok‐Jin Choi, Eunhee Sohn, Jeeyoung Oh, Seung Woo Kim, Ha Young Shin, Byung Chan Lim, Byoung Joon Kim, Kyung Seok Park, Jung‐Joon Sung, Se Hoon Kim, Sung‐Hye Park, Anastasia Zekeridou, Claudia F. Lucchinetti, Sean J. Pittock, John J. Chen, Eoin P. Flanagan, Sung‐Min Kim   +24 more
wiley   +1 more source

Vitamin D status and CYP27B1‐1260 promoter polymorphism in Tunisian patients with systemic lupus erythematosus

Molecular Genetics & Genomic Medicine, 2021
Aim An association between serum vitamin D (Vit D) levels and systemic lupus erythematosus (SLE) has been reported by several studies that suggested the involvement of genetically determined characteristics of enzymes of vitamin D metabolism.
Raouia Fakhfakh, Sawsan Feki, Aida Elleuch, Manel Neifar, Sameh Marzouk, Nesrine Elloumi, Hend Hachicha, Olfa Abida, Zouhir Bahloul, Fatma Ayadi, Hatem Masmoudi   +10 more
doaj   +1 more source