Results 241 to 250 of about 221,041 (347)

Autoimmunity and autoinflammation in pathogenesis of immunoinflammatory diseases

, 2020
Н П Шилкина, I. V. Masina, I. V. Dryazhenkova, Anatoliy Vinogradov, I. E. Yunonin   +4 more
openalex   +2 more sources

Engineered ETS1‐Nanoconjugate Restores Immune Homeostasis through Dual Immune‐Vascular Modulation in Relapsing and Progressive Multiple Sclerosis

Advanced Healthcare Materials, EarlyView.
The biomimetic nanoplatform IMNP (ETS1 pDNA/PBAE@ITP‐MM) undergoes targeted disassembly at inflammatory vascular sites to release the ETS1 plasmid (pETS1). This release initiates a cascade of effects that inhibit pathogenic pathways and support immune homeostasis. (Abbreviations: EndMT, endothelial‐to‐mesenchymal transition; EC, endothelial cell; TC, T
Feng Zhang, Si‐Bo Yang, Yan Luo, Xiao‐Di Sun, Bo‐Hao Chang, Da‐Qiang Zhou, Jun‐Jie Jiang, Ya‐Nan Li, Jie‐Hong Wu, Hui‐Juan Jin, Hang Yang, Hang Hu, Yi‐Fan Zhou, Bo Hu   +13 more
wiley   +1 more source

Plasma cells in and around the central nervous system. [PDF]

Front Immunol
Merder AK, Moseman EA.
europepmc   +1 more source

The metabolite BH4 controls T cell proliferation in autoimmunity and cancer

Nature, 2018
Shane J.F. Cronin, Corey R. Seehus, A. Weidinger, S. Talbot, S. Reissig, M. Seifert, Y. Pierson, E. McNeill, M. Longhi, B. L. Turnes, Taras Kreslavsky, Melanie Kogler, David Hoffmann, Melita Ticevic, D. Scheffer, L. Tortola, Domagoj Cikes, A. Jais, Manu Rangachari, Shuan Rao, Magdalena Paolino, M. Novatchkova, Martin Aichinger, L. Barrett, Alban Latremoliere, Gerald Wirnsberger, Guenther Lametschwandtner, M. Busslinger, S. Zicha, A. Latini, S. Robson, A. Waisman, Nick A. Andrews, M. Costigan, K. Channon, G. Weiss, A. Kozlov, M. Tebbe, K. Johnsson, C. Woolf, J. Penninger   +40 more
semanticscholar   +1 more source

High‐Throughput In Vivo Screening Using Barcoded mRNA Identifies Lipid Nanoparticles With Extrahepatic Tropism for In Situ Immunoengineering

Advanced Materials, EarlyView.
A high‐throughput in vivo mRNA LNP screening platform is developed and employed to screen a large library of 122 mRNA LNPs in vivo for delivery to immune, stromal, and parenchymal cells, identifying promising LNP candidates. A novel small particle flow cytometry‐based protein adsorption analysis method is utilized to interrogate protein corona ...
Alex G. Hamilton, Ajay S. Thatte, Junchao Xu, Zhangyi Luo, Hannah C. Safford, Kelsey L. Swingle, Jenna Muscat‐Rivera, Michael Kegel, Xuexiang Han, Ryann A. Joseph, Amanda M. Murray, Hannah C. Geisler, Ricardo C. Whitaker, Lulu Xue, Roman Spektor, Jilian R. Melamed, Drew Weissman, Michael J. Mitchell   +17 more
wiley   +1 more source

The 'target tissues' as orchestrators of autoimmune responses: the paradigm of Sjögren's syndrome. [PDF]

Clin Exp Immunol
Filika M, Katsiougiannis S.
europepmc   +1 more source

Multiomics Analyses Reveal an Essential Role of Tryptophan in Treatment of csDMARDs in Rheumatoid Arthritis

Advanced Science, EarlyView.
Rheumatoid arthritis is a disease characterized by joint inflammation. Approximately 50% of patients show insufficient response to traditional synthetic disease‐modifying antirheumatic drugs. This study aims to elucidate differential molecular profiles of the mechanisms underlying drug responses through multi‐omics strategy.
Congcong Jian, Jing Zhu, Jianhong Wu, Yan Zhang, Jianghua Chen, Huan Wang, Hengyan Liu, Ke Xu, Jiaxin Huang, Xiaoting Zhu, Yuanli Wei, Shilin Li, Tingting Wang, Xuan Huang, Qinghua Zou, Jie Zhang, Jiang Su, Xinming Du, Yaping Lu, Tianci Zhou, Yingtong Zhou, Minglong Tang, Bin Li, Xue Zhou, Qihao Wei, Qiulong Yan, Fanxin Zeng   +26 more
wiley   +1 more source

Case series of de novo occurrence of Graves' disease following thermal ablation for benign thyroid nodules: an uncommon event that should be considered. [PDF]

Eur Thyroid J
Teliti M, Grillini B, Chiardi I, Magri F, Coperchini F, Croce L, Rotondi M, Chytiris S.   +7 more
europepmc   +1 more source

VDLIN: A Deep Learning‐Based Platform for Methylcobalamin‐Inspired Immunomodulatory Compound Screening

Advanced Science, EarlyView.
Using the convolutional neural network model VDLIN, Co7 is identified as a promising therapeutic candidate. Co7 demonstrates distinct advantages over MCB by effectively balancing anti‐inflammatory and immune‐stimulatory functions, making it a potential novel approach for immune modulation.
Xuefei Guo, Yang Zhao, Xianle Rong, Chenxi Niu, Shiyu Hu, Qiang Liu, Fuping You   +6 more
wiley   +1 more source

Editorial: How underappreciated autoinflammatory mechanisms (innate immunity) dominate disparate autoimmune disorders. [PDF]

Front Immunol
Zhou Q, Yang Y, McGonagle D.
europepmc   +1 more source