Results 251 to 260 of about 221,041 (347)

Clinical significance and immunobiology of IL-21 in autoimmunity.

Journal of Autoimmunity, 2019
Di Long, Yongjian Chen, Haijing Wu, Ming Zhao, Q. Lu   +4 more
semanticscholar   +1 more source

Biocatalytic Nanoregulators Restore Joint Redox‐Immune Homeostasis in Rheumatoid Arthritis

Advanced Science, EarlyView.
Mesenchymal stem cell‐derived extracellular vesicles (EVs) coat ruthenium‐loaded metal‐organic frameworks (Ru@ZrMOF), creating a targeted therapeutic (Ru@ZrMOF/EVs). This platform scavenges ROS, generates oxygen, and polarizes macrophages from M1 to M2, alleviating inflammation, inhibiting pannus, promoting cartilage repair, and downregulating HIF‐1α ...
Xingheng Wang, Jianbo Huang, Shuwei Zhang, Sujiao Cao, Fangxue Du, Liqiang Zhou, Li Qiu, Yuanjiao Tang   +7 more
wiley   +1 more source

Islet autoimmunity and progression to type 1 diabetes in the Finnish DIPP study: comparison between genetically susceptible children with and without an affected first-degree relative. [PDF]

Diabetologia
Kuusela S, Koskenniemi JJ, Valtanen T, Pokka T, Härkönen T, Ilonen J, Lempainen J, Kyrönniemi A, Toppari J, Knip M, Keskinen P, Veijola R.   +11 more
europepmc   +1 more source

Tissue‐Resident Macrophage‐Derived E3 Ligase SMURF2 Restricts Autoimmune Inflammation by Mediating the Degradation of p‐TBK1

Advanced Science, EarlyView.
Dysregulated Tissue resident macrophage (TRMs) link to autoimmune inflammation. SMURF2 mediates Lys‐27 (K27)‐linked ubiquitination of p‐TBK1 and its degradation, which inhibits CSF1R signaling‐triggered TRM proliferation, thereby restraining the autoimmune inflammation.
Xiang An, Jun Li, Lingling Wang, Chengyuan Li, Zhenpeng Jin, Yushi Yao, Minmin Jiang, Wenlong Lin, Xiaojian Wang   +8 more
wiley   +1 more source

Role of thyroid autoimmunity independent of thyroid hormone levels in pulmonary function decline: A population-based study in euthyroid adults. [PDF]

PLoS One
Sung KH, Kwak J, Kim MK, Lim DJ, Lee JM, Chang SA, Lee J.   +6 more
europepmc   +1 more source

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

Autoantibody and biomarker detection in the follow-up of autoimmune diseases: state of the art and future perspectives. [PDF]

J Transl Autoimmun
Damoiseaux J, Renaudineau Y.
europepmc   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Periodontal Disease and Autoimmunity: What We Have Learned from Microbiome Studies in Rheumatology

, 2017
Zoe Rutter‐Locher, Nicholas R. Fuggle, Marco Orlandi, Francesco D’Aiuto, Nidhi Sofat   +4 more
openalex   +2 more sources

Intestinal virome changes precede autoimmunity in type I diabetes-susceptible children

Proceedings of the National Academy of Sciences of the United States of America, 2017
Guoyan Zhao, T. Vatanen, L. Droit, A. Park, A. Kostic, Tiffany W. Poon, H. Vlamakis, Heli Siljander, T. Härkönen, A. Hämäläinen, A. Peet, V. Tillmann, J. Ilonen, David Wang, M. Knip, R. Xavier, H. Virgin   +16 more
semanticscholar   +1 more source