Results 271 to 280 of about 207,009 (370)

Annexin A3 Represses Endothelial Permeability and Inflammation During Sepsis via Actin Cytoskeleton Modulation

Advanced Science, EarlyView.
Annexin A3 (ANXA3) plays an endogenous protective role in endothelial dysfunction in sepsis by stabilizing the actin cytoskeleton, modulating cell permeability, and inhibiting pATF2/CD62E inflammatory signaling. Abstract Increased endothelial permeability and a dysregulated inflammatory response play key roles in organ damage in sepsis.
Manyu Xing, Shuang Liang, Wei Cao, Qulian Guo, Wangyuan Zou   +4 more
wiley   +1 more source

Glycosylation Regulation by TMEM230 in Aging and Autoimmunity. [PDF]

Int J Mol Sci
Piscitelli E, Abeni E, Balbino C, Angeli E, Cocola C, Pelucchi P, Palizban M, Diaspro A, Götte M, Zucchi I, Reinbold RA.   +10 more
europepmc   +1 more source

Clinical significance and immunobiology of IL-21 in autoimmunity.

Journal of Autoimmunity, 2019
Di Long, Yongjian Chen, Haijing Wu, Ming Zhao, Q. Lu   +4 more
semanticscholar   +1 more source

DiffMC‐Gen: A Dual Denoising Diffusion Model for Multi‐Conditional Molecular Generation

Advanced Science, EarlyView.
DiffMC‐Gen, a dual‐diffusion model for 2D and 3D molecular generation, simultaneously optimizes multiple key objectives across the drug design process, enabling the generation of novel, target‐specific small‐molecule ligands with high therapeutic potential.
Yuwei Yang, Shukai Gu, Bo Liu, Xiaoqing Gong, Ruiqiang Lu, Jiayue Qiu, Xiaojun Yao, Huanxiang Liu   +7 more
wiley   +1 more source

Exposure to autoimmune disorders is associated with increased Alzheimer's disease risk in a multi-site electronic health record analysis. [PDF]

Cell Rep Med
Ramey GD, Tang A, Phongpreecha T, Yang MM, Woldemariam SR, Oskotsky TT, Montine TJ, Allen I, Miller ZA, Aghaeepour N, Capra JA, Sirota M.   +11 more
europepmc   +1 more source

Immunohistochemical characterization of the oral lesions in MRL/1 mouse (autoimmunity and lymphoproliferation).

, 1987
Yoshihisa Watanabe, Hideyuki Miyamoto, Toshitaka Yamaoka, Isao Kondô, Taro Hisada   +4 more
openalex   +2 more sources

KK2DP7 Stimulates CD11b+ Cell Populations in the Spleen to Elicit Trained Immunity for Anti‐Tumor Therapy

Advanced Science, EarlyView.
This study introduces KK2DP7, a dendrimer‐structured peptide adjuvant, as a tool to decode trained immunity's role in antitumor therapy. Splenic CD11b+ cells mediate tumor suppression via TLR2‐IRF7 activation and epigenetic reprogramming, validated by adoptive transfer experiments.
Rui Zhang, Lin Tang, Yusi Wang, Xuejing Zhou, Zhenyu Ding, Li Yang   +5 more
wiley   +1 more source

Clinical and Pathophysiological Tangles Between Allergy and Autoimmunity: Deconstructing an Old Dichotomic Paradigm. [PDF]

Clin Rev Allergy Immunol
Ramirez GA, Cardamone C, Lettieri S, Fredi M, Mormile I.   +4 more
europepmc   +1 more source

STING Agonists and How to Reach Their Full Potential in Cancer Immunotherapy

Advanced Science, EarlyView.
STING agonists show promise in preclinical studies in boosting an anti‐tumor response using the immune system. However, different limitations remain, and future research is needed to better understand how STING activation impacts the tumor microenvironment, identify effective combination strategies, and determine the best tumor types for STING agonist ...
Laura Gehrcken, Christophe Deben, Evelien Smits, Jonas R.M. Van Audenaerde   +3 more
wiley   +1 more source

Role of autoimmune phenomena in nonalcoholic fatty liver disease: Insights and limitations. [PDF]

World J Hepatol
Krishnan A, Mukherjee D.
europepmc   +1 more source