Nature Communications, 2021 Autoimmunity mediated by age-associated B cells (ABC) can affect males and females differently. Here, using a lupus-like mouse model that affects females more severely, the authors observe an ABC mediated and guanine nucleotide exchange factor (GEF ...
Edd Ricker +14 more
doaj +1 more source
Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4. [PDF]
, 2017 While it is recognized that aquaporin-4 (AQP4)-specific T cells and antibodies participate in the pathogenesis of neuromyelitis optica (NMO), a human central nervous system (CNS) autoimmune demyelinating disease, creation of an AQP4-targeted model with ...
Cruz-Herranz, Andrés +7 more
core +1 more source
Advanced Biophotonics techniques for cell and molecules manipulation associated with cancer and autoimmune diseases: the role of optical tweezers [PDF]
arXiv, 2021 Biophotonic techniques are growing in rapid rhythms enabling the monitoring of subcellular structures and non-invasive theranostic interventions in cancer and autoimmune diseases. The integration of Biophotonics with nanotechnology and biosensors brings a revolution in the micro- and nano-world with new optical tools.
arxiv
Quasispecies dynamics on a network of interacting genotypes and idiotypes: Applications to autoimmunity and immunodeficiency [PDF]
Journal of Statistical Mechanics (2016), 063501, 2015 In spite of their many facets, the phenomena of autoimmunity and immunodeficiency seem to be related to each other through the subtle links connecting retroviral mutation and action to immune response and adaptation. In a previous work, we introduced a network model of how a set of interrelated genotypes (called a quasispecies, in the stationary state)
arxiv +1 more source
Autoimmunity: The nuclear arsenal of autoimmunity [PDF]
Immunology & Cell Biology, 2007 An exciting new work recently published in Nature Immunology shows that an iconic molecule should not get all the blame for carrying out the dirty work of autoimmunity ...
openaire +3 more sources
Peroxisome proliferator-activated receptor delta limits the expansion of pathogenic Th cells during central nervous system autoimmunity. [PDF]
, 2010 Peroxisome proliferator-activated receptors (PPARs; PPAR-alpha, PPAR-delta, and PPAR-gamma) comprise a family of nuclear receptors that sense fatty acid levels and translate this information into altered gene transcription.
Axtell, Robert +11 more
core +3 more sources
Web Tool for Navigating and Plotting SomaLogic ADAT Files
Journal of Open Research Software, 2017 SOMAscan™ is a complex proteomic platform created by SomaLogic. Experimental data resulting from the assay is provided by SomaLogic in a proprietary text-based format called ADAT.
Foo Cheung +7 more
doaj +1 more source
Enhancing Medical Image Segmentation: Optimizing Cross-Entropy Weights and Post-Processing with Autoencoders [PDF]
arXiv, 2023 The task of medical image segmentation presents unique challenges, necessitating both localized and holistic semantic understanding to accurately delineate areas of interest, such as critical tissues or aberrant features. This complexity is heightened in medical image segmentation due to the high degree of inter-class similarities, intra-class ...
arxiv
Current Opinion in Immunology, 1992 The past few years have witnessed exciting developments regarding the role of cytokines in autoimmune diseases, particularly in rheumatoid arthritis and Crohn's disease, with the demonstration that anti-TNF alpha therapy is clinically beneficial and provides reproducible results.
Brennan, F, Feldmann, M
openaire +4 more sources
Apheresis in Autoimmune Encephalitis and Autoimmune Dementia [PDF]
Journal of Clinical Medicine, 2020 Autoimmune encephalitis (AE) is a rapidly progressive inflammatory neurological disease. Underlying autoantibodies can bind to neuronal surfaces and synaptic proteins resulting in psychiatric symptoms, focal neurological signs, autonomic dysfunction and cognitive decline.
Harald Prüss +3 more
openaire +3 more sources