Results 61 to 70 of about 207,009 (370)
The PD‐1 pathway in tolerance and autoimmunity
Immunological Reviews, 2010 Summary: Regulatory T cells (Tregs) and the PD‐1: PD‐ligand (PD‐L) pathway are both critical to terminating immune responses. Elimination of either can result in the breakdown of tolerance and the development of autoimmunity.
Loise M. Francisco, P. Sage, A. Sharpe
semanticscholar +1 more source
Enhancing Medical Image Segmentation: Optimizing Cross-Entropy Weights and Post-Processing with Autoencoders [PDF]
arXiv, 2023 The task of medical image segmentation presents unique challenges, necessitating both localized and holistic semantic understanding to accurately delineate areas of interest, such as critical tissues or aberrant features. This complexity is heightened in medical image segmentation due to the high degree of inter-class similarities, intra-class ...
arxiv
Current Opinion in Immunology, 1992 The past few years have witnessed exciting developments regarding the role of cytokines in autoimmune diseases, particularly in rheumatoid arthritis and Crohn's disease, with the demonstration that anti-TNF alpha therapy is clinically beneficial and provides reproducible results.
Brennan, F, Feldmann, M
openaire +4 more sources
A unique role for galectin-9 in angiogenesis and inflammatory arthritis
Arthritis Research & Therapy, 2018 Background Galectin-9 (Gal-9) is a mammalian lectin secreted by endothelial cells that is highly expressed in rheumatoid arthritis synovial tissues and synovial fluid.
Martin J. O’Brien +10 more
doaj +1 more source
Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans
Pediatrics, 2017 T Vatanen, AD Kostic, E d’Hennezel. Cell. 2016;165(4):842–853 Characterize the gut microbiota during the first 3 years of life and elucidate a mechanism by which it can shape the immune system and impact the incidence of autoimmune diseases such as type
M. Poli, Jordan S. Orange
semanticscholar +1 more source
Characterization of the Hypercitrullination Reaction in Human Neutrophils and Other Leukocytes
Mediators of Inflammation, 2015 Autoantibodies against citrullinated proteins are diagnostic for rheumatoid arthritis. However, the molecular mechanisms driving protein citrullination in patients with rheumatoid arthritis remain poorly understood. Using two independent western blotting
Yebin Zhou +4 more
doaj +1 more source
FEBS Letters, EarlyView.In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali +3 more
wiley +1 more source
Frontiers in Immunology, 2022 Lung transplantation remains as a primary treatment for end-stage lung diseases. Although remarkable improvement has been achieved due to the immunosuppressive protocols, long-term survival for lung transplant recipients (LTR) is still limited.
María Iglesias-Escudero +14 more
doaj +1 more source
Sex Differences in the Gut Microbiome Drive Hormone-Dependent Regulation of Autoimmunity
Science, 2013 Mighty Male Microbes Both genetic and environmental factors contribute to an individual's susceptibility to autoimmune disease, but the specific environmental influences are not well characterized. Markle et al. (p. 1084, published online 17 January; see
J. Markle +9 more
semanticscholar +1 more source
Assessing T cell clonal size distribution: a non-parametric approach [PDF]
PLoS ONE 9(10): e108658, 2014 Clonal structure of the human peripheral T-cell repertoire is shaped by a number of homeostatic mechanisms, including antigen presentation, cytokine and cell regulation. Its accurate tuning leads to a remarkable ability to combat pathogens in all their variety, while systemic failures may lead to severe consequences like autoimmune diseases.
arxiv +1 more source