Results 81 to 90 of about 207,009 (370)
FEBS Open Bio, EarlyView.IDMF is a derivative of dimethyl fumarate (DMF) with a unique therapeutic potential at the intersection of psoriasis and multiple sclerosis. Here, we demonstrate that it compares favorably with DMF and its other derivatives, such as Diroximel, in the zebrafish, microglia, and lymphocyte models.
Yulin He +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.Etoposide, a topoisomerase II inhibitor, reduces O‐GlcNAcylation in HepG2 liver cancer cells. Further inhibition of O‐GlcNAc transferase by OSMI‐1 enhanced etoposide‐induced apoptosis, lowering the IC50 for viability and increasing the EC50 for cytotoxicity.
Jaehoon Lee +5 more
wiley +1 more source
Statistical Inference for Genetic Relatedness Based on High-Dimensional Logistic Regression [PDF]
arXiv, 2022 This paper studies the problem of statistical inference for genetic relatedness between binary traits based on individual-level genome-wide association data. Specifically, under the high-dimensional logistic regression models, we define parameters characterizing the cross-trait genetic correlation, the genetic covariance and the trait-specific genetic ...
arxiv
Scientific ReportsMultiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system and a leading cause of neurological disability in young adults. Clinical presentation and disease course are highly heterogeneous. Typically, disease progression occurs
Theresa L. Montgomery +9 more
doaj +1 more source
Scientific Reports, 2018 Chronic obstructive pulmonary disease (COPD) is a serious global health problem characterized by chronic airway inflammation, progressive airflow limitation and destruction of lung parenchyma.
Ulf Hedström +6 more
doaj +1 more source
The Emerging Jamboree of Transformative Therapies for Autoimmune Diseases
Frontiers in Immunology, 2020 Standard treatments for autoimmune and autoinflammatory disorders rely mainly on immunosuppression. These are predominantly symptomatic remedies that do not affect the root cause of the disease and are associated with multiple side effects ...
José M. Carballido +6 more
doaj +1 more source
Correction to: Lymphocyte subset abnormalities in early diffuse cutaneous systemic sclerosis
Arthritis Research & Therapy, 2021 An amendment to this paper has been published and can be accessed via the original article.
David A. Fox +14 more
doaj +1 more source
Frontiers in Immunology, 2018 The great asymmetry of autoimmune diseases between genders represents one of the most enigmatic observations among the mosaic of autoimmunity. Sex hormones are believed to play a crucial role on this dimorphism.
V. Borba +2 more
semanticscholar +1 more source
A Data-Efficient Deep Learning Framework for Segmentation and Classification of Histopathology Images [PDF]
arXiv, 2022 The current study of cell architecture of inflammation in histopathology images commonly performed for diagnosis and research purposes excludes a lot of information available on the biopsy slide. In autoimmune diseases, major outstanding research questions remain regarding which cell types participate in inflammation at the tissue level, and how they ...
arxiv
Clinical & Translational Immunology, 2020 Objectives A dysregulated inflammatory response against the dopamine‐2 receptor (D2R) has been implicated in movement and psychiatric disorders. D2R antibodies were previously reported in a subset of these patients; however, the role of T cells in these ...
Deepti Pilli +16 more
doaj +1 more source