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Autoinflammation und Autoimmunität

Arthritis und Rheuma, 2014
ZusammenfassungAutoinflammation wird definiert als selbstgerichtete Entzündung, bei der lokale Faktoren zu einer Aktivierung von Zellen des angeborenen Immunsystems führen, mit der Folge einer Schädigung des lokalen Gewebes, die aber auch von einer generalisierten Entzündungsreaktion mit Fieber begleitet sein kann.
K. Tenbrock
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Autoinflammation and autoimmunity: Bridging the divide

Autoimmunity Reviews, 2012
As soon as autoinflammatory diseases (AIDs) emerged as new entities, they have been linked to the well known world of autoimmunity. In fact, AIDs and systemic autoimmune diseases (ADs), share some characteristics: they start with the prefix "auto" to define a pathological process directed against self; they are systemic diseases, frequently involving ...
DORIA, ANDREA, Zen M, Bettio S, Gatto M, BASSI, NICOLA, Nalotto L, GHIRARDELLO, ANNA, IACCARINO, LUCA, PUNZI, LEONARDO   +8 more
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Autoinflammation by Endogenous DNA

2011
In various mammalian developmental processes such as programmed cell death, erythropoiesis, and lens-cell differentiation, chromosomal DNA is degraded into nucleotides by a set of specific nucleases. If this process does not proceed smoothly, the undigested DNA causes various problems. For example, when chromosomal DNA is not degraded in the lens cells,
Shigekazu, Nagata, Kohki, Kawane
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Broadening the definition of autoinflammation

Seminars in Immunopathology, 2015
Initially, the concept of autoinflammation posited that there be no involvement of autoreactive B or T cells, and no evidence of infection. These criteria served well to help establish the concept, and distinguish autoinflammatory diseases from autoimmune or infectious conditions.
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What’s new in autoinflammation?

Pediatric Nephrology, 2018
The pathogenesis of autoinflammatory diseases has shed light on the concept of inflammation in general and on our understanding of the role of the innate immune system. The autoinflammatory diseases have a large spectrum with varying features of inflammation. The most common autoinflammatory diseases are those associated with periodic fevers. The delay
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Autoinflammation and Autoimmunity

2019
The elucidation of the genetic basis for hereditary recurrent fever syndromes validated the role of innate immune dysregulation in diseases formerly viewed as autoimmune. Recognizing the non-autoimmune nature of tumor necrosis factor receptor-associated periodic syndrome (TRAPS), one such syndrome, and the lack of evidence for autoantibodies or B- or T-
Dennis McGonagle, Abdulla Watad
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Proteasomes in Autoinflammation

2019
The cellular proteostasis network integrates all signals controlling protein synthesis, folding, trafficking, and clearance machineries in multiple subcellular compartments to maintain the integrity of the proteome and to ensure the survival of cells and tissues under varying proteotoxic insults.
Anja Brehm, Frédéric Ebstein, Elke Krüger   +2 more
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Cytokines in Autoinflammation

2019
Autoinflammatory diseases represent an expanding spectrum of diseases characterized by recurrent episodes of fever and systemic inflammation, due to disorders of innate immunity. Since the concept of autoinflammation was first affirmed in 1999 to define TNF-receptor associated periodic syndrome (TRAPS), many other monogenic autoinflammatory diseases ...
Angela Rösen-Wolff, Anna Rubartelli
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