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The role of mast cells in autoinflammation
Immunological Reviews, 2018SummaryThe concept of autoinflammation was proposed to define a new class of immune disorders categorized by self‐directed inflammation that is driven via activation of innate immune pathways. Within innate immunity, inflammasomes serve as intracellular signaling platforms to endogenous danger molecules and pathogens. Their key function is the cleavage
Hanna Bonnekoh +3 more
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Epigenetics in Autoinflammation
2019The molecular mechanisms of inflammation involve a series of processes that start as extracellular signals that interact with membrane-bound receptors, cell signaling cascades, nuclear factors, and epigenetic enzymes that activate a specific gene expression program.
Clara Lorente-Sorolla +2 more
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The role of ERAP1 in autoinflammation and autoimmunity
Human Immunology, 2019Autoimmune and autoinflammatory diseases affect millions worldwide. These classes of disease involve abnormal immune activation of both the innate and adaptive immune systems. While both classes of disease represent a spectrum of aberrant immune activation, excessive activation of the innate immune system has been considered causal for the inflammation
Yuliya Pepelyayeva, Andrea Amalfitano
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Inflammasomes and Autoinflammation
2019Inflammasomes are large intracellular multi-protein polymeric complexes comprised of sensors, adaptor proteins and caspases. As innate immune sensors capable of recognizing and rapidly responding to pathogen and metabolic danger signals, inflammasomes act as key modulators of initial immune responses.
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Panniculitis: A Cardinal Sign of Autoinflammation
Current Rheumatology ReviewsAbstract: Panniculitis was first described in the nineteenth century and is characterized by inflammation of the subcutaneous fat. It may be categorized in septal or lobular subtypes, but other histopathological features (e.g., presence of vasculitis, nature of inflammatory infiltrates, characteristics of fat necrosis) are also important for ...
Tiago Borges, Sérgio Silva
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Infektion oder Autoinflammation?
MMW - Fortschritte der Medizin, 2016Geht akuter Durchfall mit Fieber und/oder Erbrechen einher, ist der „Normalfall“ eine Magen-Darm-Infektion durch Viren, Bakterien oder bakterielle Toxine. Als Ausloser kommen aber auch autoinflammatorische Pathologien infrage, wie chronisch-entzundliche Darmerkrankungen und die angeborenen hereditaren rekurrierenden Fiebersyndrome.
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Urticarial Syndromes and Autoinflammation
2010Recent genetic studies of urticaria have revealed distinct molecular pathways underlying different types of urticaria, and have defined several urticarial syndromes associated with autoinflammation. Although the cutaneous presentation of urticarial syndromes is strikingly similar, many of these syndromes involve diverse features of systemic ...
Kanade Shinkai, Kieron S. Leslie
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S100 Proteins in Autoinflammation
2019Among the putative markers for autoinflammatory diseases, studies on phagocyte-derived S100 proteins (S100A8/A9, S100A12: calgranulins) are the most advanced to date. Translational studies have suggested an important role for these danger-associated molecular pattern (DAMP) molecules as robust inflammation biomarkers.
Dirk Holzinger +2 more
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The Journal of Allergy and Clinical Immunology: In Practice
Daniel L, Rosenberg, Harold M, Hoffman
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Daniel L, Rosenberg, Harold M, Hoffman
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