Results 141 to 150 of about 181,043 (245)

The Transcription Factor EGR2 Plays a Central Role in the Expansion and Function of TCRαβ + CD4 − CD8 − Double Negative T Cells in lpr Lupus Mice

Immunology, Volume 179, Issue 2, Page 224-235, October 2026.
The highly expanded TCRβ+ DNT cells in autoimmune‐prone B6/lpr mice are phenotypically and functionally different from the TCRβ+DNT cells of normal B6 mice. Conditional Egr2 deletion in B6/lpr mice not only reduces TCRβ+ DNT cell numbers but also tends to correct the phenotypic and functional abnormalities of DNT cells in B6/lpr mice. In addition, Egr2
Rujuan Dai, Zhuang Wang, Bettina Heid, Christopher M. Reilly, S. Ansar Ahmed   +4 more
wiley   +1 more source

A Blood–Brain Barrier‐Permeable Guanylhydrazone Analogue of the ASIC3 Activator GMQ Inhibits Human Glioblastoma Stem Cell Growth In Vitro

ChemMedChem, Volume 21, Issue 18, 28 September 2026.
The acid‐sensing ion channel 3 (ASIC3), physiologically located in the peripheral nervous system, was found in stem cells of CNS‐located glioblastoma multiforme (GBM CSCs); its chronic activation in the CNS kills dysfunctional GBM CSCs with no effect on ASIC3‐lacking CNS tissues.
Leonardo Maiorana, Nicoletta Collura, Andrea Gotti, Giulia De Leonardis, Greta Donati, Alice Maiocchi, Luciana Marinelli, Andrea Menegon, Pierfausto Seneci   +8 more
wiley   +1 more source

Clinical management of clonal hematopoiesis

Cancer, Volume 132, Issue 18, 15 September 2026.
ABSTRACT Clonal hematopoiesis, particularly clonal hematopoiesis of indeterminate potential and clonal cytopenia of undetermined significance, is an age‐related premalignant condition characterized by the expansion of hematopoietic clones carrying somatic mutations.
Kelly S. Chien, Guillermo Garcia‐Manero   +1 more
wiley   +1 more source

Clustering reveals diagnostic overlap between Still’s disease and a hyperinflammatory subset of seronegative rheumatoid arthritis

Scientific Reports
Still’s disease (SD) and rheumatoid arthritis (RA), particularly seronegative RA, may overlap clinically and biologically, complicating diagnosis. We explored data-driven overlaps between SD, seronegative RA, and seropositive RA using unsupervised ...
Alexandre Mercier-Guery, Thomas El-Jammal, Nour El-Nayef, Emmanuel Massy, Nicolas Fournier, Pascal Sève, Cyrille Confavreux, Yvan Jamilloux, Fabienne Coury   +8 more
doaj   +1 more source

A Case of VEXAS Syndrome Presenting with Unexplained Headache

Turkish Journal of Hematology
Ünal Ataş, Fadime Nurcan Alhan, Dilek Beypınar, Sevinç Şahin, Şakir Özgür Keşkek   +4 more
doaj   +1 more source

Late-onset expression of an autoinflammatory disease: Identification and functional characterization of a mosaic variant in NLRC4

International audienceBackground/Objectives: NLRC4 gene encodes an essential component of the NLRC4inflammasome, a multiprotein complex involved in activating inflammatory pathways.
Lézot, Frédéric, Rabbaa, Mira, Piterboth, William, Levergeois, Romain, Assrawi, Eman, Diab, Farah, Dastot Le Moal, Florence, Fabre, Marc, Mani, Rahma, Brandao, Quentin, Giurgea, Irina, Karabina, Sonia, A, Louvrier, Camille, Arenas, Angela, Daskalopoulou, Aphrodite, Amselem, Serge   +15 more
core   +2 more sources

Genetic Basis of Autoinflammatory Skin Diseases. Part I. Genetic Pathways of Complex Autoinflammatory Skin Diseases

This continuing medical education article provides a comprehensive review of the genetic underpinnings of complex autoinflammatory skin diseases, with a focus on neutrophilic dermatoses, autoinflammatory syndromes, and certain vasculitides.
Lin, Rachel, Elman, Scott A, Alvarez Cespedes, David, Maderal, Andrea, Burke, Olivia M, Thorson, Willa   +5 more
core   +1 more source

Renal Amyloidosis in Pediatric Autoinflammatory Syndromes: Subclinical Onset, Early Biomarkers, and Clues for Timely Characterization and Interventions. [PDF]

J Clin Med
Arsiwala N, Rigante D.
europepmc   +1 more source

A Novel Dominantly Segregating PSMB10 Splice-Site Variant in Familial Autoinflammatory Disease with Immunoproteasome and Interferon-Related Dysregulation. [PDF]

Genes (Basel)
Onat UI, Bülbül A, Sigli D, Sever EA, Ugurlu S, Ozdogan AH, Tahir Turanli E.   +6 more
europepmc   +1 more source

TRAPS: An Autosomal Dominant Autoinflammatory Syndrome

, 2007
Hereditary periodic fever syndromes are genetic autoinflammatory disorders characterized by recurrent attacks of fever and inflammation. These diseases include familial Mediterranean fever (FMF), Tumor necrosis factor receptor-associated periodic ...
Karatay, Saliha, ALKAN MELİKOĞLU, Meltem   +1 more
core