Results 81 to 90 of about 157,940 (239)

Update on ocular manifestations of the main monogenic and polygenic autoinflammatory diseases

Frontiers in Ophthalmology
Autoinflammatory diseases include disorders with a genetic cause and also complex syndromes associated to polygenic or multifactorial factors. Eye involvement is present in many of them, with different extent and severity.
Alex Fonollosa, Alex Fonollosa, Ester Carreño, Ester Carreño, Antonio Vitale, Ankur K. Jindal, Athimalaipet V. Ramanan, Laura Pelegrín, Borja Santos-Zorrozua, Verónica Gómez-Caverzaschi, Luca Cantarini, Claudia Fabiani, José Hernández-Rodríguez   +12 more
doaj   +1 more source

PEPITEM Regulates the Synovial Microenvironment During Immune‐Mediated Inflammatory Arthritis to Limit Disease

Arthritis &Rheumatology, EarlyView.
Objective Here we investigate the status of the adiponectin–PEPITEM pathway in early, treatment naive rheumatoid arthritis (RA) and psoriatic arthritis (PsA) and the therapeutic efficacy of PEPITEM administration in preclinical models. Methods Peripheral blood was isolated from patients with clinical suspect arthralgia and suspected inflammatory ...
Mussarat Wahid, Samuel Kemble, Oladimeji Abudu, Anella Saviano, Christopher Mahony, Jonathan W. Lewis, Thomas A. Nicholson, Anna Schettino, Noemi Marigliano, Kathryn Frost, Jenefa Begum, Alyssa M. Urbanowski, Marion Limo, Rakesh Jha, Sandra Martinez Jarquin, Laleh Pezhman, Abbie E. A. Degan, Amy E. Anderson, Charlotte G. Smith, Armaiti Batki, Holly Adams, Francesco Caso, Raffaele Scarpa, Iain McInnes, Stefan Siebert, Arthur G. Pratt, Andrew Filer, Karim Raza, Adam P. Croft, Myriam Chimen, Felicity de Cogan, G. Ed Rainger, Asif J. Iqbal, Francesco Maione, Helen M. McGettrick   +34 more
wiley   +1 more source

Pharmacologic management of renal involvement in monogenic autoinflammatory diseases

European Journal of Medical Research
Kidney involvement represents one of the main targets of the systemic inflammatory process and is underscored by a heterogeneous pathology ranging from amyloidosis to non-amyloid-related damage rooted in inflammasome activation.
Ahmed Fayed, Mohamed Tharwat Hegazy, Jurgen Sota, Carla Gaggiano, Gaafar Ragab   +4 more
doaj   +1 more source

Dry eye disease and spondyloarthritis: expanding the spectrum of systemic inflammatory disorders associated with ocular surface disease. Data from the international AIDA Network Spondyloarthritis Registry

Frontiers in Medicine
ObjectiveDry eye disease (DED) is a condition associated with a myriad of systemic disorders. According to recent preliminary data, axial spondylarthritis (axial-SpA) could represent a new entity associated with DED. Therefore, this study aimed to assess
Antonio Vitale, Antonio Vitale, Valeria Caggiano, Valeria Caggiano, Eduardo Martín-Nares, Nunzia Di Meglio, Nunzia Di Meglio, Cristian Sica, Cristian Sica, Andrea Hinojosa-Azaola, Maria Orsetta Perfetti, Maria Orsetta Perfetti, Alessandra Pagliara, Alessandra Pagliara, Giorgia Guidetti, Giorgia Guidetti, Alex Fonollosa, Roberta Lopez, Roberta Lopez, Jessica Sbalchiero, Jessica Sbalchiero, Jurgen Sota, Jurgen Sota, Ester Carreño, Ester Carreño, Perla Ayumi Kawakami-Campos, Stefano Gentileschi, Stefano Gentileschi, Alejandra de-la-Torre, Gian Marco Tosi, Gian Marco Tosi, Maria Antonietta Mazzei, Maria Antonietta Mazzei, Alberto Balistreri, Alberto Balistreri, Bruno Frediani, Bruno Frediani, Luca Cantarini, Luca Cantarini, Claudia Fabiani, Claudia Fabiani   +40 more
doaj   +1 more source

Pathogenic implications, incidence, and outcomes of COVID-19 in autoimmune inflammatory joint diseases and autoinflammatory disorders

Advances in Rheumatology, 2021
As the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread rapidly, there are still many unresolved questions of how this virus would impact on autoimmune inflammatory ...
Piero Ruscitti, Alessandro Conforti, Paola Cipriani, Roberto Giacomelli, Marco Tasso, Luisa Costa, Francesco Caso   +6 more
doaj   +1 more source

A Review of Ankylosing Spondylitis [PDF]

, 2017
Ankylosing spondylitis (AS) is a systemic autoimmune disorder that induces ankylosis of the spine (fusion of the vertebrae at their various joints) and inflammatory arthritis of peripheral joints among other symptoms.
Owen, Hannah L
core   +1 more source

A Rare RIPK3 Variant Enhances Necroptosis and Promotes Inflammation in a Still Disease–Like Autoinflammatory Syndrome

Arthritis &Rheumatology, EarlyView.
Objective Still disease represents a prototypical polygenic systemic autoinflammatory disease, characterized by recurrent systemic inflammation and dysregulation of innate immunity. Despite extensive clinical characterization, familial clustering Still disease remains unreported.
Longfang Chen, Qihua Dai, Yu Xiao, Jialin Dai, Mengyan Wang, Yuning Ma, Yujie Shen, Zhimo Xu, Jianfen Meng, Xia Chen, Da Yi, Yue Sun, Hui Shi, Honglei Liu, Xiaobing Cheng, Yutong Su, Junna Ye, Huihui Chi, Zhuochao Zhou, Tingting Liu, Jialin Teng, Chengde Yang, Jinchao Jia, Qiongyi Hu   +23 more
wiley   +1 more source

γδ T Cells in Autoinflammatory Diseases

Cells
Autoinflammatory diseases are characterized by inappropriate activation of innate immunity resulting in excessive or persistent inflammation in the absence of infection.
Ilan Bank
doaj   +1 more source

Schnitzler Syndrome: Insights into Its Pathogenesis, Clinical Manifestations, and Current Management

Biomolecules
Schnitzler syndrome is a rare disorder characterized by a chronic urticarial rash associated with immunoglobulin M (IgM) monoclonal gammopathy. Schnitzler syndrome shares strong clinicopathologic similarities with monogenic IL-1-mediated autoinflammatory
Antoine Braud, Dan Lipsker
doaj   +1 more source

NLRP12-associated systemic autoinflammatory diseases in children

Pediatric Rheumatology Online Journal, 2022
Systemic autoinflammatory diseases (SAIDs) are a group of monogenic diseases characterized by disordered innate immunity, which causes excessive activation of inflammatory pathways.
Hui-fang Wang
doaj   +1 more source