Results 61 to 70 of about 157,940 (239)

KCNJ2 is Required for NLRP3 Inflammasome Activation That Drives Allergic Airway Inflammation and Remodeling

Advanced Science, EarlyView.
This study aims to evaluate the impact of the potassium channel KCNJ2 on asthma development. KCNJ2 promotes NLRP3 inflammasome activation through both Ca2+ influx and K+ efflux in airway epithelial cells, which drives allergic airway inflammation and remodeling, suggesting a promising therapeutic target for asthma.
Yachao Cui, Shumei Wu, Yang Peng, Yiqi Liu, Li Che, Shiying Chen, Feng Zhang, Dajiang Qin, Shiyue Li, Pixin Ran, Wenguang Yin   +10 more
wiley   +1 more source

Axial spondyloarthritis in patients with recurrent fever attacks: data from the AIDA network registry for undifferentiated autoInflammatory diseases (USAIDs)

Frontiers in Medicine, 2023
BeckgroundDespite the recent advances in the field of autoinflammatory diseases, most patients with recurrent fever episodes do not have any defined diagnosis.
Antonio Vitale, Antonio Vitale, Valeria Caggiano, Valeria Caggiano, Isabel Silva, Daniel G. Oliveira, Daniel G. Oliveira, Piero Ruscitti, Francesco Ciccia, Ibrahim Vasi, Abdurrahman Tufan, Giuseppe Lopalco, Ibrahim A. AlMaghlouth, Jurgen Sota, Jurgen Sota, Ewa Wiesik-Szewczyk, Carla Gaggiano, Carla Gaggiano, Henrique Ayres Mayrink Giardini, Veronica Spedicato, Gaafar Ragab, Gaafar Ragab, Florenzo Iannone, Alberto Balistreri, Micol Frassi, José Hernández-Rodríguez, Claudia Fabiani, Claudia Fabiani, Paolo Falsetti, Paolo Falsetti, Nunzia Di Meglio, Nunzia Di Meglio, Bruno Frediani, Bruno Frediani, Maria Antonietta Mazzei, Maria Antonietta Mazzei, Donato Rigante, Donato Rigante, Raquel Faria, Luca Cantarini, Luca Cantarini   +40 more
doaj   +1 more source

Immunology in clinic review series; focus on autoinflammatory diseases: role of inflammasomes in autoinflammatory syndromes [PDF]

, 2012
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90366/1/j.1365-2249.2011.04535.x ...
Franchi, Luigi, Ozkurede, V. U.
core   +1 more source

Autoinflammatory Pustular Neutrophilic Diseases [PDF]

Dermatologic Clinics, 2013
This article provides a new categorization of inflammatory pustular dermatoses in the context of recent genetic and biological insights. Monogenic diseases with pustular phenotypes are discussed, including deficiency of interleukin 1 receptor antagonist, deficiency of the interleukin 36 receptor antagonist, CARD14-associated pustular psoriasis, and ...
Haley B, Naik, Edward W, Cowen
openaire   +2 more sources

Dual Covalent Targeting of STING Cysteines 292/309 Disrupts Functional Oligomerization and Enables Potent Antagonist Development

Advanced Science, EarlyView.
We report a rational design strategy for STING antagonists by dual covalent targeting of Cys292/309 in its C‐terminal domain, directly preventing functional oligomerization. Through covalent warhead repurposing, we identified P005091 and revealed its unique dual‐cysteine mechanism.
Yuxuan Zhao, Ling Huang, Wenjing Qin, Bin Zhang, Yang Yang, Xue Chen, Xiaoquan Wang, Weilin Zhou, Feiyang Chen, Zhenyu Li, Liyuan Le, Yiqiu Zhang, Zhen Xiang, Lu Zhang, Fei Wang, Dan Lei, Zi‐zhe Cai, Ying Gao, Yong Chen, Xuecen Wang, Junmin Quan, Shuixing Zhang, Xianzhang Bu, Xin Yue   +23 more
wiley   +1 more source

Efficacy of combined JAK1/2 inhibition and cyclosporine in paediatric-onset Still’s disease with lung involvement: a case report

Pediatric Rheumatology Online Journal
Background Paediatric-onset Still’s disease is a severe autoinflammatory disorder marked by high fever, systemic inflammation, rash, organomegaly, and arthritis.
Serena Palmeri, Maddalena Lancieri, Jacopo Ferro, Pietro Salvati, Martino Cheli, Riccardo Papa, Silvia Rosina, Stefano Volpi, Valerio Gaetano Vellone, Angelo Ravelli, Marco Gattorno, Roberta Caorsi   +11 more
doaj   +1 more source

Skeletal pathologies in extant crocodilians as a window into the paleopathology of fossil archosaurs

The Anatomical Record, EarlyView.
Abstract Crocodilians, together with birds, are the only extant relatives to many extinct archosaur groups, making them highly important for interpreting paleopathological conditions in a phylogenetic disease bracketing model. Despite this, comprehensive data on osteopathologies in crocodilians remain scarce.
Alexis Cornille, Kyla Beguesse, Ewan Wolff, Clemens Zinner, Patrick Asbach, François Clarac, Florian Witzmann   +6 more
wiley   +1 more source

A retrospective review of autoinflammatory diseases in Saudi children at a rheumatology clinic

Annals of Saudi Medicine, 2012
BACKGROUND AND OBJECTIVE: Published data from Saudi Arabia regarding autoinflammatory diseases are scarce. In this study, we describe the clinical and laboratory features of autoinflammatory diseases in Saudi children. DESIGN AND SETTING: Restrospective,
Abdullatif Alenazi, Abdullah Al Sonbul, Suliman Al Jumaah, Ali Al Mehaidib, Sulaiman M. Al-Mayouf   +4 more
doaj   +1 more source

Autoinflammatory syndromes: diagnosis and management [PDF]

, 2010
During the last decades the description of autoinflammatory syndromes induced great interest among the scientific community. Mainly rheumatologists, immunologists and pediatricians are involved in the discovery of etiopathogenesis of these syndromes and ...
Sara De Sanctis, Manuela Nozzi, Marianna Del Torto, Alessandra Scardapane, Stefania Gaspari, Giuseppina de Michele, Luciana Breda, Francesco Chiarelli   +7 more
core   +2 more sources

Autoinflammatory Bone Diseases

Balkan Medical Journal
Autoinflammatory bone diseases (AIBDs) constitute a recently identified subset of autoinflammatory diseases. These conditions are characterized by an exaggerated inflammatory response in the bones without any apparent etiology. Inflammatory bone lesions associated with AIBDs exhibit chronic inflammation, are typically culture-negative, and do not ...
Haslak, Fatih, Akay, Nergis, Gul, Umit, Gunalp, Aybuke, Konte, Elif Kilic, Sahin, Sezgin, Kasapcopur, Ozgur   +6 more
openaire   +4 more sources