Results 41 to 50 of about 147,251 (203)

Therapeutic Outcomes in VEXAS Syndrome: A Multicenter Comparative Cohort of Allogeneic Hematopoietic Stem Cell Transplantation and Hypomethylating Agents

American Journal of Hematology, EarlyView.
Key findings of therapeutic outcomes from a multi‐center cohort of VEXAS patients. ABSTRACT Hypomethylating agents (HMA) and allogeneic hematopoietic stem cell transplantation (alloHSCT) have both demonstrated remissions in VEXAS; however, comparative data is lacking.
Saubia Fathima, Margaret Mei‐Kay Wong, Jesus Gonzalez‐Lugo, Susan M. Geyer, Ali Alsugair, Maria Sirenko, Kimberly J. Langer, Terra L. Lasho, Christy Finke, Jun Choi, Maher Abdul‐Hay, Gary Ho, Mark R. Litzow, Aasiya Matin, Urshila Durani, Mehrdad Hefazi, William J. Hogan, Mithun V. Shah, Aref Al‐Kali, Kebede H. Begna, Naseema Gangat, Antoine N. Saliba, Ronald S. Go, Tariq Kewan, Gabriel Bartoo, Jade Kutzke, Kristen McCullough, Kenneth J. Warrington, Megan Sullivan, Kaaren K. Reichard, Horatiu Olteanu, Hemant Murthy, Talha Badar, Yael Kusne, Jeanne Palmer, Saurabh Chhabra, Nathan Punwani, Mary Riwes, Joseph P. McGuirk, Elizabeth F. Krakow, Amelia Langston, Taxiarchis Kourelis, David Dingli, James Foran, Matthew J. Koster, Mrinal M. Patnaik, David B. Beck, Hassan B. Alkhateeb, Abhishek A. Mangaonkar   +48 more
wiley   +1 more source

The needed daily dose of colchicine in patients with Familial Mediterranean Fever may be higher in women: a study on behalf of the JIR cohort

Arthritis Research & Therapy
Background At present, there are no data on the relationship between colchicine dose and weight in patients with Familial Mediterranean Fever (FMF). We aimed at describing the daily colchicine dose in a cohort of FMF patients.
Ilenia Di Cola, Alessandra Bartoli, Léa Savey, Fatima Bensalek, Marion Delplanque, Rim Bourguiba, Zohra Aknouche, Isabelle Kone-Paut, Linda Rossi-Semerano, Isabelle Melki, Brigitte Bader-Meunier, Bénédicte Neven, Pierre Quartier, Guilaine Boursier, Laurence Cuisset, Gilles Grateau, Véronique Hentgen, Sophie Georgin-Lavialle   +17 more
doaj   +1 more source

Skeletal pathologies in extant crocodilians as a window into the paleopathology of fossil archosaurs

The Anatomical Record, EarlyView.
Abstract Crocodilians, together with birds, are the only extant relatives to many extinct archosaur groups, making them highly important for interpreting paleopathological conditions in a phylogenetic disease bracketing model. Despite this, comprehensive data on osteopathologies in crocodilians remain scarce.
Alexis Cornille, Kyla Beguesse, Ewan Wolff, Clemens Zinner, Patrick Asbach, François Clarac, Florian Witzmann   +6 more
wiley   +1 more source

A Multifaceted Interplay Among Hemophagocytosis, Interleukin‐18, and Type I Interferon Distinguishes Still Disease From Other Autoinflammatory Diseases

Arthritis &Rheumatology, EarlyView.
Objective The unknown pathophysiology and the lack of specific features for systemic juvenile idiopathic arthritis and adult‐onset Still disease (collectively known as Still disease; SD) delay diagnosis and appropriate treatment. The goal of this study was to identify features and mechanisms that distinguish SD from other systemic autoinflammatory ...
Yvonne M. Mueller, Charlotte Girard, Harmen J. G. van de Werken, Stefan J. Erkeland, Dwin G. B. Grashof, Laurie Vaillant, Renske J. H. den Dekker, Iris van Zuijen, Sharon Veenbergen, Fanny Coffin, Eric Bindels, Yvan Jamilloux, Katerina Laskari, Vassili Soumelis, Bruno Fautrel, Cem Gabay, Peter D. Katsikis   +16 more
wiley   +1 more source

PEPITEM Regulates the Synovial Microenvironment During Immune‐Mediated Inflammatory Arthritis to Limit Disease

Arthritis &Rheumatology, EarlyView.
Objective Here we investigate the status of the adiponectin–PEPITEM pathway in early, treatment naive rheumatoid arthritis (RA) and psoriatic arthritis (PsA) and the therapeutic efficacy of PEPITEM administration in preclinical models. Methods Peripheral blood was isolated from patients with clinical suspect arthralgia and suspected inflammatory ...
Mussarat Wahid, Samuel Kemble, Oladimeji Abudu, Anella Saviano, Christopher Mahony, Jonathan W. Lewis, Thomas A. Nicholson, Anna Schettino, Noemi Marigliano, Kathryn Frost, Jenefa Begum, Alyssa M. Urbanowski, Marion Limo, Rakesh Jha, Sandra Martinez Jarquin, Laleh Pezhman, Abbie E. A. Degan, Amy E. Anderson, Charlotte G. Smith, Armaiti Batki, Holly Adams, Francesco Caso, Raffaele Scarpa, Iain McInnes, Stefan Siebert, Arthur G. Pratt, Andrew Filer, Karim Raza, Adam P. Croft, Myriam Chimen, Felicity de Cogan, G. Ed Rainger, Asif J. Iqbal, Francesco Maione, Helen M. McGettrick   +34 more
wiley   +1 more source

Efficacy of combined JAK1/2 inhibition and cyclosporine in paediatric-onset Still’s disease with lung involvement: a case report

Pediatric Rheumatology Online Journal
Background Paediatric-onset Still’s disease is a severe autoinflammatory disorder marked by high fever, systemic inflammation, rash, organomegaly, and arthritis.
Serena Palmeri, Maddalena Lancieri, Jacopo Ferro, Pietro Salvati, Martino Cheli, Riccardo Papa, Silvia Rosina, Stefano Volpi, Valerio Gaetano Vellone, Angelo Ravelli, Marco Gattorno, Roberta Caorsi   +11 more
doaj   +1 more source

A Rare RIPK3 Variant Enhances Necroptosis and Promotes Inflammation in a Still Disease–Like Autoinflammatory Syndrome

Arthritis &Rheumatology, EarlyView.
Objective Still disease represents a prototypical polygenic systemic autoinflammatory disease, characterized by recurrent systemic inflammation and dysregulation of innate immunity. Despite extensive clinical characterization, familial clustering Still disease remains unreported.
Longfang Chen, Qihua Dai, Yu Xiao, Jialin Dai, Mengyan Wang, Yuning Ma, Yujie Shen, Zhimo Xu, Jianfen Meng, Xia Chen, Da Yi, Yue Sun, Hui Shi, Honglei Liu, Xiaobing Cheng, Yutong Su, Junna Ye, Huihui Chi, Zhuochao Zhou, Tingting Liu, Jialin Teng, Chengde Yang, Jinchao Jia, Qiongyi Hu   +23 more
wiley   +1 more source

A retrospective review of autoinflammatory diseases in Saudi children at a rheumatology clinic

Annals of Saudi Medicine, 2012
BACKGROUND AND OBJECTIVE: Published data from Saudi Arabia regarding autoinflammatory diseases are scarce. In this study, we describe the clinical and laboratory features of autoinflammatory diseases in Saudi children. DESIGN AND SETTING: Restrospective,
Abdullatif Alenazi, Abdullah Al Sonbul, Suliman Al Jumaah, Ali Al Mehaidib, Sulaiman M. Al-Mayouf   +4 more
doaj   +1 more source

Axial spondyloarthritis in patients with recurrent fever attacks: data from the AIDA network registry for undifferentiated autoInflammatory diseases (USAIDs)

Frontiers in Medicine, 2023
BeckgroundDespite the recent advances in the field of autoinflammatory diseases, most patients with recurrent fever episodes do not have any defined diagnosis.
Antonio Vitale, Antonio Vitale, Valeria Caggiano, Valeria Caggiano, Isabel Silva, Daniel G. Oliveira, Daniel G. Oliveira, Piero Ruscitti, Francesco Ciccia, Ibrahim Vasi, Abdurrahman Tufan, Giuseppe Lopalco, Ibrahim A. AlMaghlouth, Jurgen Sota, Jurgen Sota, Ewa Wiesik-Szewczyk, Carla Gaggiano, Carla Gaggiano, Henrique Ayres Mayrink Giardini, Veronica Spedicato, Gaafar Ragab, Gaafar Ragab, Florenzo Iannone, Alberto Balistreri, Micol Frassi, José Hernández-Rodríguez, Claudia Fabiani, Claudia Fabiani, Paolo Falsetti, Paolo Falsetti, Nunzia Di Meglio, Nunzia Di Meglio, Bruno Frediani, Bruno Frediani, Maria Antonietta Mazzei, Maria Antonietta Mazzei, Donato Rigante, Donato Rigante, Raquel Faria, Luca Cantarini, Luca Cantarini   +40 more
doaj   +1 more source

Childhood versus adulthood-onset autoinflammatory disorders: myths and truths intertwined

Reumatismo, 2013
Autoinflammatory disorders are characterized by spontaneous episodes of systemic inflammation deriving from inherited defects of the innate immune system.
L. Cantarini, A. Vitale, O.M. Lucherini, I. Muscari, F. Magnotti, G. Brizi, B. Frediani, G.D. Sebastiani, M. Galeazzi, D. Rigante   +9 more
doaj   +1 more source