Results 31 to 40 of about 5,018,411 (238)

Autoinflammatory Disease Reloaded: A Clinical Perspective [PDF]

, 2010
Our understanding of the etiology of autoinflammatory disease is growing rapidly. Recent advances offer new opportunities for therapeutic intervention and suggest that the definition of what constitutes an autoinflammatory disease should be ...
Aksentijevich, Ivona, Goldbach-Mansky, Raphaela, Kastner, Daniel L.   +2 more
core   +1 more source

A rare case of an NLRP12-associated autoinflammatory disease

, 2021
Pathogenic variants in nucleotide-binding oligomerization-like receptor protein 12 (NLRP12) have been recently suggested as possible causes of autoinflammatory syndromes and should be considered for the differential diagnosis in the patients presenting ...
Seven, Mehmet, Ugurlu, Serdal, KARACAN, İLKER, Eren, Hatice, Zare, Jale, Calhan, Sevgi S., Ayla, Ali Y.   +6 more
core   +1 more source

Autoinflammatory diseases and the kidney

Immunologic Research, 2023
AbstractThe kidney represents an important target of systemic inflammation. Its involvement in monogenic and multifactorial autoinflammatory diseases (AIDs) vary from peculiar and relatively frequent manifestations to some rare but severe features that may end up requiring transplantation.
Mohamed Tharwat Hegazy, Ahmed Fayed, Rossana Nuzzolese, Jurgen Sota, Gaafar Ragab   +4 more
openaire   +4 more sources

Hints for Genetic and Clinical Differentiation of Adult-Onset Monogenic Autoinflammatory Diseases

Mediators of Inflammation, 2019
Monogenic autoinflammatory diseases (mAIDs) are inherited errors of innate immunity characterized by systemic inflammation recurring with variable frequency and involving the skin, serosal membranes, synovial membranes, joints, the gastrointestinal tube,
Carla Gaggiano, Donato Rigante, Antonio Vitale, Orso Maria Lucherini, Alessandra Fabbiani, Giovanna Capozio, Chiara Marzo, Viviana Gelardi, Salvatore Grosso, Bruno Frediani, Alessandra Renieri, Luca Cantarini   +11 more
doaj   +1 more source

Autoinflammatory diseases in Pediatrics

Archivos Argentinos de Pediatria, 2013
Monogenic autoinflammatory syndromes are caused by mutations in protein-coding genes that have a pivotal role in the regulation of the inflammatory response. Due to their genetic nature, most of these syndromes usually begin during childhood. They are clinically characterized by recurrent episodes of systemic inflammation (fever with different clinical
Silvia M, Meiorin, Graciela, Espada, Carlos, Rosè   +2 more
openaire   +4 more sources

Induced Pluripotent Stem Cell-Derived Monocytes/Macrophages in Autoinflammatory Diseases

Frontiers in Immunology, 2022
The concept of autoinflammation, first proposed in 1999, refers to a seemingly unprovoked episode of sterile inflammation manifesting as unexplained fever, skin rashes, and arthralgia.
Takayuki Tanaka, Takayuki Tanaka, Takeshi Shiba, Yoshitaka Honda, Yoshitaka Honda, Kazushi Izawa, Takahiro Yasumi, Megumu K. Saito, Ryuta Nishikomori   +8 more
doaj   +1 more source

Cutaneous manifestations of autoinflammatory diseases [PDF]

Rheumatology and Immunology Research, 2021
Abstract Autoinflammatory diseases (AIDs) are a heterogeneous group of disorders in which recurrent or continuous aseptic inflammation arises primarily through antigen-independent hyperactivation of the innate immune system. The skin is frequently involved with a wide variety of cutaneous manifestations, most of which are non-specific.
Wu, Di, Shen, Min, Yao, Qingping
openaire   +2 more sources

Galantamine attenuates autoinflammation in a mouse model of familial mediterranean fever

Molecular Medicine, 2022
Background Autoinflammatory diseases, a diverse group of inherited conditions characterized by excessive innate immune activation, have limited therapeutic options.
Ibrahim T. Mughrabi, Mahendar Ochani, Mirza Tanovic, Ping Wang, Betty Diamond, Barbara Sherry, Valentin A. Pavlov, Seza Ozen, Daniel L. Kastner, Jae Jin Chae, Yousef Al-Abed   +10 more
doaj   +1 more source

Role of Inner Ear Macrophages and Autoimmune/Autoinflammatory Mechanisms in the Pathophysiology of Inner Ear Disease

Frontiers in Neurology, 2022
Macrophages play important roles in tissue homeostasis and inflammation. Recent studies have revealed that macrophages are dispersed in the inner ear and may play essential roles in eliciting an immune response.
Toru Miwa, Toru Miwa, Takayuki Okano
doaj   +1 more source

Eating disorders, autoimmune, and autoinflammatory disease [PDF]

, 2017
OBJECTIVES: Identifying factors associated with risk for eating disorders is important for clarifying etiology and for enhancing early detection of eating disorders in primary care.
Mortensen, P.B., Thornton, L.M., Bulik, C.M., Quaranta, M, Stephanie Zerwas, Koch, SV, Petersen, Liselotte, Thornton, Laura M., Mortensen, PB, Bulik, CM, Quaranta, Michela, Janne Tidselbak Larsen, Zerwas, S, Larsen, Janne Tidselbak, Larsen, JT, Zerwas, Stephanie, Laura M. Thornton, Bulik, Cynthia M., Susanne Vinkel Koch, Quaranta, M., Pisetsky, D., Larsen, J.T., David Pisetsky, Cynthia M. Bulik, Pisetsky, D, Preben Bo Mortensen, Pisetsky, David, Mortensen, Preben Bo, Thornton, LM, Michela Quaranta, Petersen, L., Liselotte Petersen, Petersen, L, Koch, Susanne Vinkel, Koch, S.V., Zerwas, S.   +35 more
core   +1 more source